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Am J Transl Res. 2016 Aug 15;8(8):3513-21. eCollection 2016.

MicroRNA-141 inhibits glioma cells growth and metastasis by targeting TGF-β2.

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Department of Neurosurgery, The First Hospital of Jilin University Changchun 130021, Jilin Province, P. R. China.
Department of Ophthalmology, The Second Hospital of Jilin University Changchun 130041, Jilin Province, P. R. China.


MicroRNA-141 (miR-141) has been reported to function as tumor suppressor in many types of cancer. However, the molecular function and underlying mechanisms of miR-141 in glioma is still unknown. The aims of this study were to investigate miR-141 expression and determine its biological function and underlying mechanism in glioma. In this study, we found that miR-141 expression levels, both in glioma cell lines and in tissues, were significantly lower than that in a normal human astrocyte cell line or adjacent non-cancerous tissues. Overexpression of miR-141 significantly inhibited glioma cell proliferation, colony formation, migration and invasion in vitro, as well as suppressed glioma tumor growth in vivo. In addition, transforming growth factor beta 2 (TGF-β2) was identified as a target of miR-141 in glioma cells. TGF-β2 expression was also found to be upregulated, and negatively associated with miR-141 in glioma tissues. TGF-β2 over-expression partly reversed the effect caused by transfection of miR-141 mimic. These findings together suggested that miR-141 functioned as tumor suppressor by targeting TGF-β2, and that miR-141 might be a promising therapeutic strategy for future treatment of glioma.


Glioma; TGF-β2; invasion; miR-141; migration; proliferation


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