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Nutr Neurosci. 2017 May;20(4):238-245. doi: 10.1080/1028415X.2015.1115213. Epub 2015 Nov 30.

Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells.

Author information

1
a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA.
2
b Department of Psychology , Simmons College , Boston , MA , USA.

Abstract

OBJECTIVES:

The present study was carried out to determine if lyophilized açaí fruit pulp (genus, Euterpe), rich in polyphenols and other bioactive antioxidant and anti-inflammatory phytochemicals, is efficacious in reversing age-related cognitive deficits in aged rats.

METHODS:

The diets of 19-month-old Fischer 344 rats were supplemented for 8 weeks with 2% Euterpe oleracea (EO), Euterpe precatoria (EP), or a control diet. Rats were tested in the Morris water maze and then blood serum from the rats was used to assess inflammatory responses of BV-2 microglial cells.

RESULTS:

After 8 weeks of dietary supplementation with 2% EO or EP, rats demonstrated improved working memory in the Morris water maze, relative to controls; however, only the EO diet improved reference memory. BV-2 microglial cells treated with blood serum collected from EO-fed rats produced less nitric oxide (NO) than control-fed rats. Serum from both EO- and EP-fed rats reduced tumor necrosis factor-alpha (TNF-α). There is a relationship between performance in the water maze and the production of NO and TNF-α by serum-treated BV-2 cells, such that serum from rats with better performance was more protective against inflammatory signaling.

DISCUSSION:

Protection of memory during aging by supplementation of lyophilized açaí fruit pulp added to the diet may result from its ability to influence antioxidant and anti-inflammatory signaling.

KEYWORDS:

Aging; Açaí; Cognition; Inflammation; Memory; Oxidative stress

PMID:
26618555
DOI:
10.1080/1028415X.2015.1115213
[Indexed for MEDLINE]

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