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Oxid Med Cell Longev. 2015;2015:295497. doi: 10.1155/2015/295497. Epub 2015 Feb 23.

Influence of vitamin C supplementation on oxidative stress and neutrophil inflammatory response in acute and regular exercise.

Author information

1
Institute of Pathophysiology, Medical Faculty Pristina, 38220 Kosovska Mitrovica, Serbia.
2
Institute of Biochemistry, Medical Faculty Pristina, 38220 Kosovska Mitrovica, Serbia.
3
Institute of Physiology, Medical Faculty Pristina, 38220 Kosovska Mitrovica, Serbia.
4
Department of Informatics and Computer Sciences, Academy of Criminalistic and Police Studies, Cara Dusana 196, 11080 Belgrade, Serbia.

Abstract

Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting from exercise induces activation of inflammatory cells followed by the increased activity of myeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aim of this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.

PMID:
25802681
PMCID:
PMC4352897
DOI:
10.1155/2015/295497
[Indexed for MEDLINE]
Free PMC Article

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