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Can Urol Assoc J. 2014 Jul;8(7-8):E554-7. doi: 10.5489/cuaj.1802.

Vas deferens invasion: A neglected issue in the sampling of radical prostatectomy materials.

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Gulhane Military Medical Academy and School of Medicine, Department of Pathology, Ankara, Turkey.


A radical prostatectomy affects the prostate, bilateral seminal vesicles (SV), and the distal parts of the bilateral vasa deferentia (VD). SV invasion (SVI) is associated with an increased risk of lymph node metastasis and recurrence. However, the significance of VD invasion (VDI), either with or without the involvement of their surgical margins, has not been fully appreciated. We think VDI might have an independent prognostic significance, as does SVI, and should be incorporated into the pathology guidelines and the staging systems of prostatic adenocarcinoma. Our case illustrates this.

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