Format

Send to

Choose Destination
Enferm Infecc Microbiol Clin. 2005 Dec;23(10):609-14.

[Empirical antifungal therapy in selected patients with persistent fever and neutropenia].

[Article in Spanish]

Author information

1
Unidad de Gestión Clínica de Enfermedades Infecciosas, Hospitales Universitarios Virgen del Rocío, Sevilla, Spain. cisnerosjm@telefonica.net

Abstract

Empirical antifungal treatment (EAT) in neutropenia is mainly aimed at improving the poor prognosis of patients with invasive fungal infection through early treatment. The Infectious Diseases Society of America recommends initiating EAT in patients with persistent fever after 5-7 days of antibacterial treatment, and in those in whom remission of neutropenia is not imminent. Nevertheless, EAT has not been shown to be more effective than a placebo, it does not show better results than directed antifungal treatment, its effectiveness is minimal, it is not innocuous, and it is not very efficient with the use of most antifungal agents. All considered, we believe that the aforementioned recommendation for EAT treatment is unjustified. In its place we propose the application of EAT in patients selected on the basis of clinical criteria and risk factors.

PMID:
16324551
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center