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The selective neurokinin 3 antagonist AZD2624 does not improve symptoms or cognition in schizophrenia: a proof-of-principle study.
Litman RE, Smith MA, Desai DG, Simpson T, Sweitzer D, Kanes SJ. Litman RE, et al. J Clin Psychopharmacol. 2014 Apr;34(2):199-204. doi: 10.1097/JCP.0000000000000071. J Clin Psychopharmacol. 2014. PMID: 24525659 Clinical Trial.
This study investigates the efficacy, tolerability, and cognitive effects of AZD2624, a selective, orally active NK(3) receptor antagonist, in symptomatic patients with schizophrenia. ...Results of the trial do not support a role for the NK(3) antagonist AZD2624 as …
This study investigates the efficacy, tolerability, and cognitive effects of AZD2624, a selective, orally active NK(3) receptor antag …
In vitro assessment of metabolic drug-drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies.
Li Y, Zhou D, Ferguson SS, Dorff P, Simpson TR, Grimm SW. Li Y, et al. Xenobiotica. 2010 Nov;40(11):721-9. doi: 10.3109/00498254.2010.512670. Xenobiotica. 2010. PMID: 20937004
No time-dependent inactivation of CYP3A4/5 activity (midazolam 1'-hydroxylation) by AZD2624 was observed. AZD2624 demonstrated weak to no inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP2D6. AZD2624 was not an inducer of CYP1A2 or CYP2B6. Althou …
No time-dependent inactivation of CYP3A4/5 activity (midazolam 1'-hydroxylation) by AZD2624 was observed. AZD2624 demonstrated …