Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1972 1
1973 4
1975 1
1976 1
1977 3
1978 4
1979 1
1980 2
1981 2
1982 1
1983 7
1984 1
1985 1
1986 2
1987 6
1988 4
1989 3
1990 2
1991 2
1992 1
1993 1
1994 3
1995 3
1997 4
1998 3
1999 3
2000 2
2001 4
2002 2
2003 5
2004 11
2005 17
2006 23
2007 12
2008 10
2009 12
2010 12
2011 8
2012 8
2013 9
2014 10
2015 5
2016 8
2017 6
2018 6
2019 4
2020 3
2021 8
2022 13
2023 3
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

245 results

Results by year

Filters applied: . Clear all
The following terms were ignored: "", OR
Page 1
Helenalin - A Sesquiterpene Lactone with Multidirectional Activity.
Drogosz J, Janecka A. Drogosz J, et al. Curr Drug Targets. 2019;20(4):444-452. doi: 10.2174/1389450119666181012125230. Curr Drug Targets. 2019. PMID: 30317996 Review.
Unfortunately, helenalin's ability to cause allergic reactions and its toxicity to healthy tissues prevented so far the development of this sesquiterpene lactone as an anticancer or anti-inflammatory drug. Recently, the new interest in the biological properties, as well as …
Unfortunately, helenalin's ability to cause allergic reactions and its toxicity to healthy tissues prevented so far the development o …
Recent Patents on Anti-Cancer Potential of Helenalin.
Kriplani P, Guarve K. Kriplani P, et al. Recent Pat Anticancer Drug Discov. 2020;15(2):132-142. doi: 10.2174/1574892815666200702142601. Recent Pat Anticancer Drug Discov. 2020. PMID: 32614752 Review.
BACKGROUND: Arnica montana, containing helenalin as its principal active constituent, is the most widely used plant to treat various ailments. ...RESULTS: Helenalin has shown its anti-cancer potential to treat multiple types of tumors, both in vitro and in vivo. ...
BACKGROUND: Arnica montana, containing helenalin as its principal active constituent, is the most widely used plant to treat various …
Arnica montana L.: Doesn't Origin Matter?
Schmidt TJ. Schmidt TJ. Plants (Basel). 2023 Oct 11;12(20):3532. doi: 10.3390/plants12203532. Plants (Basel). 2023. PMID: 37895999 Free PMC article. Review.
The main bioactive constituents are sesquiterpene lactones (STLs) of the helenanolide type. Among these, a variety of esters of helenalin and 11alpha,13-dihydrohelenalin with low-molecular-weight carboxylic acids, namely, acetic, isobutyric, methacrylic, methylbutyric as w …
The main bioactive constituents are sesquiterpene lactones (STLs) of the helenanolide type. Among these, a variety of esters of helenalin
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
Yang M, Zhang W, Yu X, Wang F, Li Y, Zhang Y, Yang Y. Yang M, et al. Med Sci Monit. 2021 Jun 14;27:e930083. doi: 10.12659/MSM.930083. Med Sci Monit. 2021. PMID: 34125740 Free PMC article.
BACKGROUND Helenalin is a pseudoguaianolide natural product with anti-cancer activities. ...Helenalin relieved the inhibitory effect of TrxR1 on ROS production. ...
BACKGROUND Helenalin is a pseudoguaianolide natural product with anti-cancer activities. ...Helenalin relieved the inhibitory …
In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity.
Šadibolová M, Juvonen RO, Auriola S, Boušová I. Šadibolová M, et al. Arch Toxicol. 2022 Mar;96(3):793-808. doi: 10.1007/s00204-021-03218-6. Epub 2022 Jan 6. Arch Toxicol. 2022. PMID: 34989853
Sesquiterpene lactone helenalin is used as an antiphlogistic in European and Chinese folk medicine. ...In humans, CYP3A4 and CYP3A5 followed by CYP2B6 were the main enzymes responsible for the hepatic metabolism of helenalin. The extrahepatic CYP2A13 oxidized hel
Sesquiterpene lactone helenalin is used as an antiphlogistic in European and Chinese folk medicine. ...In humans, CYP3A4 and CYP3A5 f …
In Vitro Metabolism of Helenalin Acetate and 11alpha,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.
Jürgens FM, Behrens M, Humpf HU, Robledo SM, Schmidt TJ. Jürgens FM, et al. Metabolites. 2022 Jan 17;12(1):88. doi: 10.3390/metabo12010088. Metabolites. 2022. PMID: 35050210 Free PMC article.
Its main bioactive constituents are sesquiterpene lactones (STLs) of the helenalin and 11alpha,13-dihydrohelenalin types. Besides the mentioned activity, the tincture and its isolated STLs have antileishmanial activity. ...Therefore, in vitro metabolism experiments with li …
Its main bioactive constituents are sesquiterpene lactones (STLs) of the helenalin and 11alpha,13-dihydrohelenalin types. Besides the …
[Arnica allergy].
Hausen BM. Hausen BM. Hautarzt. 1980 Jan;31(1):10-7. Hautarzt. 1980. PMID: 6993423 Review. German.
The low toxic threshold often causes also primary toxic skin reactions. The sesquiterpene lactones helenalin, its acetate and methacrylate have been proved to be the primary sensitizers. ...
The low toxic threshold often causes also primary toxic skin reactions. The sesquiterpene lactones helenalin, its acetate and methacr …
Helenalin reduces Staphylococcus aureus infection in vitro and in vivo.
Boulanger D, Brouillette E, Jaspar F, Malouin F, Mainil J, Bureau F, Lekeux P. Boulanger D, et al. Vet Microbiol. 2007 Jan 31;119(2-4):330-8. doi: 10.1016/j.vetmic.2006.08.020. Epub 2006 Aug 26. Vet Microbiol. 2007. PMID: 17010538
These studies revealed that proliferation of S. aureus in bovine mammary epithelial MAC-T cells treated in the presence or absence of TNF-alpha was markedly reduced in the presence of helenalin. Secondly, in vivo effects of helenalin were investigated. ...Significan …
These studies revealed that proliferation of S. aureus in bovine mammary epithelial MAC-T cells treated in the presence or absence of TNF-al …
Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2.
Dirsch VM, Stuppner H, Vollmar AM. Dirsch VM, et al. Cancer Res. 2001 Aug 1;61(15):5817-23. Cancer Res. 2001. PMID: 11479221
Helenalin also did not induce CD95 or CD95-ligand expression. On the other hand, helenalin was found to induce the release of cytochrome c from mitochondria that was not inhibited by the caspase inhibitor zVAD-fmk, which indicated that cytochrome c release precedes
Helenalin also did not induce CD95 or CD95-ligand expression. On the other hand, helenalin was found to induce the release of
The activity of Artemisia spp. and their constituents against Trypanosomiasis.
Naß J, Efferth T. Naß J, et al. Phytomedicine. 2018 Aug 1;47:184-191. doi: 10.1016/j.phymed.2018.06.002. Epub 2018 Jun 9. Phytomedicine. 2018. PMID: 30166103 Review.
The plants contained numerous chemical constituents including 3',4'-dihydroxybonanzin, apigenin, betulinic acid, bonanzin, dehydroleucodine, dihydroluteolin, dracunculin and bis-dracunculin, helenalin, nepetin, scoparol, scopoletin, stigmasterol, (Z)-p-hydroxy cinnamic aci …
The plants contained numerous chemical constituents including 3',4'-dihydroxybonanzin, apigenin, betulinic acid, bonanzin, dehydroleucodine, …
245 results