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Page 1
Rvx 208.
[No authors listed] [No authors listed] Drugs R D. 2011;11(2):207-13. doi: 10.2165/11595140-000000000-00000. Drugs R D. 2011. PMID: 21679009 Free PMC article. Review.
RVX 208 (RVX-208; RVX000222) is a first-in-class novel small molecule in development by Resverlogix Corporation for acute coronary syndromes, atherosclerosis and Alzheimer disease. ...
RVX 208 (RVX-208; RVX000222) is a first-in-class novel small molecule in development by Resverlogix Corporation …
Selective BET inhibitor RVX-208 ameliorates periodontal inflammation and bone loss.
Sun M, Clayton N, Alam S, Asmussen N, Wong A, Kim JH, Luong G, Mokhtari S, Pellei D, Carrico CK, Schwartz Z, Boyan BD, Giannobile WV, Sahingur SE, Lin Z. Sun M, et al. J Clin Periodontol. 2023 Dec;50(12):1658-1669. doi: 10.1111/jcpe.13887. Epub 2023 Oct 19. J Clin Periodontol. 2023. PMID: 37855275
The effect of RVX-208 on osteoclast transcriptome was studied by RNA sequencing. ...RVX-208 administration prevented the alveolar bone loss in vivo. ...
The effect of RVX-208 on osteoclast transcriptome was studied by RNA sequencing. ...RVX-208 administration preve …
An evaluation of RVX-208 for the treatment of atherosclerosis.
Nikolic D, Rizzo M, Mikhailidis DP, Wong NC, Banach M. Nikolic D, et al. Expert Opin Investig Drugs. 2015;24(10):1389-98. doi: 10.1517/13543784.2015.1083010. Expert Opin Investig Drugs. 2015. PMID: 26364508 Review.
INTRODUCTION: RVX-208 is a first-in-class, orally active, novel small molecule in development by Resverlogix Corporation (Calgary, AB, Canada). ...AREAS COVERED: In this review, the authors evaluate the use of RVX-208 as an agent for the treatment of a …
INTRODUCTION: RVX-208 is a first-in-class, orally active, novel small molecule in development by Resverlogix Corporation (Calg …
In vitro biosynthesis, isolation, and identification of predominant metabolites of 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (RVX-208).
Khmelnitsky YL, Mozhaev VV, Cotterill IC, Michels PC, Boudjabi S, Khlebnikov V, Madhava Reddy M, Wagner GS, Hansen HC. Khmelnitsky YL, et al. Eur J Med Chem. 2013 Jun;64:121-8. doi: 10.1016/j.ejmech.2013.03.062. Epub 2013 Apr 10. Eur J Med Chem. 2013. PMID: 23644195
Glucuronidation of RVX-208 catalyzed by rabbit liver S9 fraction was optimized to produce M4 in amounts sufficient for structural characterization. ...Both samples confirmed M5 as a product of oxidation of primary hydroxyl group of RVX-208 to carboxyli …
Glucuronidation of RVX-208 catalyzed by rabbit liver S9 fraction was optimized to produce M4 in amounts sufficient for structu …
RVX 208: A novel BET protein inhibitor, role as an inducer of apo A-I/HDL and beyond.
Ghosh GC, Bhadra R, Ghosh RK, Banerjee K, Gupta A. Ghosh GC, et al. Cardiovasc Ther. 2017 Aug;35(4). doi: 10.1111/1755-5922.12265. Cardiovasc Ther. 2017. PMID: 28423226 Free article. Review.
RVX 208 acts primarily by increasing apo A-I (apolipoprotein A-I) and HDL levels. RVX 208 has a novel action of increasing larger, more cardio-protective HDL particles. ...
RVX 208 acts primarily by increasing apo A-I (apolipoprotein A-I) and HDL levels. RVX 208 has a novel action of …
Viral Hijacking of BET Proteins.
Chen IP, Ott M. Chen IP, et al. Viruses. 2022 Oct 17;14(10):2274. doi: 10.3390/v14102274. Viruses. 2022. PMID: 36298829 Free PMC article. Review.
How Might Bromodomain and Extra-Terminal (BET) Inhibitors Operate in Cardiovascular Disease?
Schooling CM, Zhao JV. Schooling CM, et al. Am J Cardiovasc Drugs. 2019 Apr;19(2):107-111. doi: 10.1007/s40256-018-00315-3. Am J Cardiovasc Drugs. 2019. PMID: 30693439 Review.
Notably, the effect of RVX-208 on MACE was largely driven by revascularizations, but fewer interventions in the treatment arm could have arisen accidently from favorable effects of RVX-208 on HDL-C and C-reactive protein influencing decisions about pat …
Notably, the effect of RVX-208 on MACE was largely driven by revascularizations, but fewer interventions in the treatment arm …
RVX-208, a stimulator of apolipoprotein AI gene expression for the treatment of cardiovascular diseases.
McNeill E. McNeill E. Curr Opin Investig Drugs. 2010 Mar;11(3):357-64. Curr Opin Investig Drugs. 2010. PMID: 20178050 Review.
In vitro, RVX-208 stimulated APOAI transcription and was associated with dose-dependent increases in apoAI mRNA and protein. ...Plasma exposure to RVX-208 was dose-dependent following single or multiple oral doses and the drug was readily absorbed. ...
In vitro, RVX-208 stimulated APOAI transcription and was associated with dose-dependent increases in apoAI mRNA and protein. . …
RVX-208, an inducer of Apolipoprotein A-I, inhibits the particle production of hepatitis B virus through activation of cGAS-STING pathway.
Shu D, Cheng L, Yuan K, Liu D, Wei H. Shu D, et al. Antivir Ther. 2023 Dec;28(6):13596535231219639. doi: 10.1177/13596535231219639. Antivir Ther. 2023. PMID: 38037795 Free article.
METHODS: RVX-208 was used to treat HepG2.2.15 cell, a HepG2 derived cell line stably producing HBV virus. ...RNA-seq, immunoblots and real-time PCR were used to analyze the functional mechanism of RVX-208. RESULTS: RVX-208 could elevate t …
METHODS: RVX-208 was used to treat HepG2.2.15 cell, a HepG2 derived cell line stably producing HBV virus. ...RNA-seq, immunobl …
RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist.
McLure KG, Gesner EM, Tsujikawa L, Kharenko OA, Attwell S, Campeau E, Wasiak S, Stein A, White A, Fontano E, Suto RK, Wong NC, Wagner GS, Hansen HC, Young PR. McLure KG, et al. PLoS One. 2013 Dec 31;8(12):e83190. doi: 10.1371/journal.pone.0083190. eCollection 2013. PLoS One. 2013. PMID: 24391744 Free PMC article.
Increased synthesis of Apolipoprotein A-I (ApoA-I) and HDL is believed to provide a new approach to treating atherosclerosis through the stimulation of reverse cholesterol transport. RVX-208 increases the production of ApoA-I in hepatocytes in vitro, and in vivo in …
Increased synthesis of Apolipoprotein A-I (ApoA-I) and HDL is believed to provide a new approach to treating atherosclerosis through the sti …
51 results