PMID- 31586624
OWN - NLM
STAT- In-Data-Review
LR  - 20191206
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1726
DP  - 2020 Jan 1
TI  - Apelin-36 mediates neuroprotective effects by regulating oxidative stress,
      autophagy and apoptosis in MPTP-induced Parkinson's disease model mice.
PG  - 146493
LID - S0006-8993(19)30547-5 [pii]
LID - 10.1016/j.brainres.2019.146493 [doi]
AB  - Parkinson's disease (PD), a common human neurodegenerative disorder, is
      characterized by the presence of intraneuronal Lewy bodies composed principally
      of abnormal aggregated and post-translationally modified alpha-synuclein. In our 
      previous research, we have demonstrated the neuroprotective effect of Apelin-36, 
      a neuroendocrine peptide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin
      (MPTP)-lesioned PD model mice. Therefore, this study was designed to evaluate the
      neuroprotective mechanism of Apelin-36 against MPTP-induced neurotoxicity in
      mice. The results showed that MPTP-induced the depletion of dopamine in the
      striatum (STR) was partially reversed by Apelin-36. Apelin-36 also improved the
      activity of antioxidant system including superoxide dismutase (SOD) and
      glutathione (GSH), and decreased the overproduction of malondialdehyde (MDA) in
      the substantia nigra pars compacta (SNpc) and STR of MPTP-treated mice. Moreover,
      Apelin-36 downregulated inducible nitric oxide synthase (iNOS) and nitrated
      alpha-synuclein expression. Furthermore, Apelin-36 significantly promoted
      autophagy indicated by the up-regulation of LC3-II and Beclin1 and inhibition of 
      p62 expression in the SNpc and STR of MPTP-treated mice. The protective effect of
      Apelin-36 was also associated with the inhibition of the apoptosis
      signal-regulating kinase 1 (ASK1)/c-Jun N-terminal kinase (JNK) signaling pathway
      and inactivation of caspase-3. Taken together, our findings demonstrated that the
      neuroprotective mechanism of Apelin-36 against MPTP-induced neurotoxicity in mice
      might be related to decreasing the aggregation of nitrated alpha-synuclein and
      alleviating oxidative stress as well as promoting autophagy and inhibiting
      ASK1/JNK/caspase-3 apoptotic pathway, which provides a novel strategy for PD
      treatment.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Zhu, Junge
AU  - Zhu J
AD  - Cheeloo College of Medicine, Shandong University, 250014 Jinan, China.
FAU - Gao, Wenming
AU  - Gao W
AD  - Basic Medical Sciences, Jining Medical University, 272067 Jining, China.
FAU - Shan, Xuehua
AU  - Shan X
AD  - Basic Medical Sciences, Jining Medical University, 272067 Jining, China.
FAU - Wang, Chunmei
AU  - Wang C
AD  - Neurobiology Institute, Jining Medical University, 272067 Jining, China.
FAU - Wang, Huiqing
AU  - Wang H
AD  - Cheeloo College of Medicine, Shandong University, 250014 Jinan, China.
FAU - Shao, Ziqi
AU  - Shao Z
AD  - Cheeloo College of Medicine, Shandong University, 250014 Jinan, China.
FAU - Dou, Shanshan
AU  - Dou S
AD  - Basic Medical Sciences, Jining Medical University, 272067 Jining, China.
FAU - Jiang, Yunlu
AU  - Jiang Y
AD  - Neurobiology Institute, Jining Medical University, 272067 Jining, China.
FAU - Wang, Chuangong
AU  - Wang C
AD  - Basic Medical Sciences, Jining Medical University, 272067 Jining, China.
      Electronic address: wang.chg@163.com.
FAU - Cheng, Baohua
AU  - Cheng B
AD  - Neurobiology Institute, Jining Medical University, 272067 Jining, China.
      Electronic address: chengbh1979@163.com.
LA  - eng
PT  - Journal Article
DEP - 20191003
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
OTO - NOTNLM
OT  - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridin
OT  - Apelin-36
OT  - Autophagy
OT  - Nitrated alpha-synuclein
OT  - Oxidative stress
OT  - Parkinson's disease
EDAT- 2019/10/07 06:00
MHDA- 2019/10/07 06:00
CRDT- 2019/10/07 06:00
PHST- 2019/08/08 00:00 [received]
PHST- 2019/09/28 00:00 [revised]
PHST- 2019/10/02 00:00 [accepted]
PHST- 2019/10/07 06:00 [pubmed]
PHST- 2019/10/07 06:00 [medline]
PHST- 2019/10/07 06:00 [entrez]
AID - S0006-8993(19)30547-5 [pii]
AID - 10.1016/j.brainres.2019.146493 [doi]
PST - ppublish
SO  - Brain Res. 2020 Jan 1;1726:146493. doi: 10.1016/j.brainres.2019.146493. Epub 2019
      Oct 3.