PMID- 31412755
OWN - NLM
STAT- Publisher
LR  - 20190815
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
DP  - 2019 Aug 15
TI  - Validity and Reliability of Neurological Scores in Mice Exposed to Middle
      Cerebral Artery Occlusion.
PG  - STROKEAHA119026652
LID - 10.1161/STROKEAHA.119.026652 [doi]
AB  - Background and Purpose- The selection of appropriate neurological scores and
      tests is crucial for the evaluation of stroke consequences. The validity and
      reliability of neurological deficit scores and tests has repeatedly been
      questioned in ischemic stroke models in the past. Methods- In 198 male mice
      exposed to transient intraluminal middle cerebral artery occlusion, we examined
      the validity and reliability of 11 neurological scores (Bederson score 0-3,
      Bederson score 0-4, Bederson score 0-5, modified neurological severity [0-14],
      subjective overall impression [0-10], or simple neurological tests: grip test,
      latency to move body length test, pole test, wire hanging test, negative geotaxis
      test, and elevated body swing test) in the acute stroke phase, that is, after 24 
      hours. Combinations of neurological scores or tests for predicting infarct volume
      were statistically analyzed. Results- Infarct volume was left skewed (median
      [Q1-Q3], 78.4 [54.8-101.3] mm(3)). Among all tests, the Bederson (0-5; r=0.63,
      P<0.001), modified neurological severity (r=0.80, P<0.001), and subjective
      overall impression (r=-0.63, P<0.001) scores had the highest test validities,
      using infarct volume as external reference. Subjective overall impression had the
      best agreement between 5 raters (Kendall W=0.11, P<0.001). The Bederson (0-5)
      score discriminated infarct volume in mice with small (</=50 mm(3); r=0.33,
      P=0.027) and large (>50 mm(3); r=0.48, P<0.001) brain infarcts, all other tests
      only in mice with large infarcts. Combining subjective overall impression with
      Bederson (0-5) score explained 47.6% of the variance of infarct volume.
      Conclusions- Despite their simplicity, the Bederson (0-5) score, modified
      neurological severity score, and subjective overall impression have reasonable
      validity and reliability in the acute stroke phase. The Bederson (0-5) score
      equally distinguishes infarct volume in small and large infarcts.
FAU - Bieber, Michael
AU  - Bieber M
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
FAU - Gronewold, Janine
AU  - Gronewold J
AD  - Department of Neurology, University Hospital Essen, University of Duisburg-Essen,
      Germany (J. Gronewold, A.-C.S., F.L., S.M., C.K., D.M.H.).
FAU - Scharf, Anne-Carina
AU  - Scharf AC
AD  - Department of Neurology, University Hospital Essen, University of Duisburg-Essen,
      Germany (J. Gronewold, A.-C.S., F.L., S.M., C.K., D.M.H.).
FAU - Schuhmann, Michael K
AU  - Schuhmann MK
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
FAU - Langhauser, Friederike
AU  - Langhauser F
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
AD  - Department of Neurology, University Hospital Essen, University of Duisburg-Essen,
      Germany (J. Gronewold, A.-C.S., F.L., S.M., C.K., D.M.H.).
FAU - Hopp, Sarah
AU  - Hopp S
AD  - Departments of Neurosurgery, University Hospital Wurzburg, Germany (S.H.).
FAU - Mencl, Stine
AU  - Mencl S
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
AD  - Department of Neurology, University Hospital Essen, University of Duisburg-Essen,
      Germany (J. Gronewold, A.-C.S., F.L., S.M., C.K., D.M.H.).
FAU - Geuss, Eva
AU  - Geuss E
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
FAU - Leinweber, Jonas
AU  - Leinweber J
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
FAU - Guthmann, Josua
AU  - Guthmann J
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
FAU - Doeppner, Thorsten R
AU  - Doeppner TR
AD  - Department of Neurology, University of Gottingen Medical School, Germany
      (T.R.D.).
FAU - Kleinschnitz, Christoph
AU  - Kleinschnitz C
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
AD  - Department of Neurology, University Hospital Essen, University of Duisburg-Essen,
      Germany (J. Gronewold, A.-C.S., F.L., S.M., C.K., D.M.H.).
FAU - Stoll, Guido
AU  - Stoll G
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
FAU - Kraft, Peter
AU  - Kraft P
AD  - From the Department of Neurology, University Hospital Wurzburg, Germany (M.B.,
      M.K.S., F.L., S.M., E.G., J.L., J. Guthmann, C.K., G.S., P.K.).
AD  - Department of Neurology, Klinikum Main-Spessart, Lohr, Germany (P.K.).
FAU - Hermann, Dirk M
AU  - Hermann DM
AD  - Department of Neurology, University Hospital Essen, University of Duisburg-Essen,
      Germany (J. Gronewold, A.-C.S., F.L., S.M., C.K., D.M.H.).
LA  - eng
PT  - Journal Article
DEP - 20190815
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
SB  - IM
OTO - NOTNLM
OT  - animals
OT  - behavior
OT  - infarction, middle cerebral artery
OT  - mice
OT  - stroke
EDAT- 2019/08/16 06:00
MHDA- 2019/08/16 06:00
CRDT- 2019/08/16 06:00
PHST- 2019/08/16 06:00 [entrez]
PHST- 2019/08/16 06:00 [pubmed]
PHST- 2019/08/16 06:00 [medline]
AID - 10.1161/STROKEAHA.119.026652 [doi]
PST - aheadofprint
SO  - Stroke. 2019 Aug 15:STROKEAHA119026652. doi: 10.1161/STROKEAHA.119.026652.