PMID- 31353465
OWN - NLM
STAT- Publisher
LR  - 20190812
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
DP  - 2019 Jul 28
TI  - Anal prevalence of HPV in women with pre-malignant lesion or cancer in the cervix
      and anal canal simultaneously: cross-sectional study.
LID - 10.1002/ijgo.12933 [doi]
AB  - OBJECTIVE: To determine the prevalence of anal HPV genotypes and associated
      factors in women with pre-malignant lesion or cancer in the cervix and anal
      canal. METHODS: A prospective, cross-sectional study analyzed DNA samples taken
      from women with cervical pre-malignant lesions or cancer to identify anal HPV by 
      polymerase chain reaction (PCR). The prevalence of high-risk HPV (HR-HPV) in
      women with intraepithelial neoplasia and anal cancer was calculated;
      sociodemographic and clinical risk factors were identified using multivariate
      analysis. RESULTS: A total of 152 patients were included (mean age 37.8 +/- 10.01
      years), of whom 101 (66.4%) had anal HR-HPV. Fourteen different anal HPV types
      were identified. HPV 16 and 18 were found in 30 (52.6%) anal high-grade squamous 
      intraepithelial lesions (HSIL), and HPV 31 and 33 in 21 (36.8%) lesions. In the
      logistic regression analysis, the factors that remained associated with HR-HPV
      types were: an anal histopathology report of HSIL or invasive carcinoma (odds
      ratio [OR] 8.96, 95% confidence interval [CI] 3.40-23.57; P<0.0001) and alcohol
      consumption (OR 2.20, 95% CI 1.01-4.80; P=0.04). CONCLUSION: Prevalence of HR-HPV
      is high in the anal canal of women with cervical and anal pre-malignant lesions
      simultaneously or cancer of the cervix and/or anal canal. HPV 16, 31, 33, and 18 
      were the four major genotypes identified.
CI  - (c) 2019 International Federation of Gynecology and Obstetrics.
FAU - Heraclio, Sandra A
AU  - Heraclio SA
AD  - Department of Lower Genital Tract Pathology, Instituto de Medicina Integral
      Professor Fernando Figueira (IMIP), Recife, PE, Brazil.
FAU - de Souza, Alex S R
AU  - de Souza ASR
AD  - Department of Fetal Medicine and Ultrasonography, Instituto de Medicina Integral 
      Professor Fernando Figueira (IMIP), Recife, PE, Brazil.
FAU - Silveira, Raquel K
AU  - Silveira RK
AD  - Department of Coloproctology, Instituto de Medicina Integral Professor Fernando
      Figueira (IMIP), Recife, PE, Brazil.
FAU - Torres, Leuridan C
AU  - Torres LC
AD  - Translational Health Research Laboratory, Instituto de Medicina Integral
      Professor Fernando Figueira (IMIP), Recife, PE, Brazil.
FAU - Nunes, Maria J G
AU  - Nunes MJG
AD  - Keizo Asami Laboratory of Immunopathology, Federal University of Pernambuco,
      Recife, PE, Brazil.
FAU - Amorim, Melania M R
AU  - Amorim MMR
AD  - Department of Women's Health, Instituto de Medicina Integral Professor Fernando
      Figueira (IMIP), Recife, PE, Brazil.
LA  - eng
GR  - IMIP/Instituto de Medicina Integral Prof. Fernando Figueira
PT  - Journal Article
DEP - 20190728
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
OTO - NOTNLM
OT  - HPV
OT  - Anal canal
OT  - Cancer of the uterine cervix
OT  - Genotyping
OT  - Risk factors
EDAT- 2019/07/30 06:00
MHDA- 2019/07/30 06:00
CRDT- 2019/07/30 06:00
PHST- 2018/09/07 00:00 [received]
PHST- 2019/02/21 00:00 [revised]
PHST- 2019/07/26 00:00 [accepted]
PHST- 2019/07/30 06:00 [pubmed]
PHST- 2019/07/30 06:00 [medline]
PHST- 2019/07/30 06:00 [entrez]
AID - 10.1002/ijgo.12933 [doi]
PST - aheadofprint
SO  - Int J Gynaecol Obstet. 2019 Jul 28. doi: 10.1002/ijgo.12933.