PMID- 31072372
OWN - NLM
STAT- In-Process
LR  - 20190610
IS  - 1471-2407 (Electronic)
IS  - 1471-2407 (Linking)
VI  - 19
IP  - 1
DP  - 2019 May 9
TI  - Prognostic impact of tumor location in colon cancer: the Monitoring of Cancer
      Incidence in Japan (MCIJ) project.
PG  - 431
LID - 10.1186/s12885-019-5644-y [doi]
AB  - BACKGROUND: Colorectal cancer (CRC) is globally one of the most common cancers.
      Although studies have found a significant prognostic impact of cancer location
      for right-sided colon cancers compared with those of the left-side, evidence is
      lacking in a Japanese population. Therefore, we investigated 5-year net survival 
      in colon cancer by tumor site in a Japanese population. METHODS: Diagnoses
      obtained between 2006 and 2008 in 21 population-based cancer registries from the 
      Monitoring of Cancer Incidence in Japan (MCIJ) project were used. Colon cancer
      patients were categorized as having right-sided (C18.0-18.4) or left-sided colon 
      cancer (C18.5-C18.7). We calculated the 5-year net survival for subjects
      diagnosed from 2006 until 2008 by anatomical subsite according to sex, age
      groups, tumor stage at diagnosis. We applied the excess mortality model to
      calculate excess hazard ratios (EHRs) and 95% confidential intervals (CIs) with
      and without adjustment for age, sex and cancer stages to evaluate the effect of
      location of colon cancer. RESULTS: This study analyzed a total of 62,350 colon
      cancer subjects. Five-year net survivals for subjects with left- and right-sided 
      colon cancer were 74.0% (95% CI, 73.4-74.7%) and 70.4% (95% CI, 69.7-71.0%),
      respectively. Compared with left-sided colon cancers, the EHR for right-sided
      colon cancers was 1.20 (95% CI, 1.16-1.25) after adjustment for age, sex and
      stage. CONCLUSION: Our study found that the net survival for right-sided colon
      cancer was significantly lower than that for left-sided colon cancer. The
      anatomical site of cancer in the colon might be an important stratification
      factor in future studies of colon cancer.
FAU - Nakagawa-Senda, Hiroko
AU  - Nakagawa-Senda H
AD  - Department of Public Health, Nagoya City University Graduate School of Medical
      Science, Nagoya, Japan.
FAU - Hori, Megumi
AU  - Hori M
AD  - Division of Cancer Statistics Integration, Center for Cancer Control and
      Information Services, National Cancer Center, Tokyo, Japan.
FAU - Matsuda, Tomohiro
AU  - Matsuda T
AD  - Division of Surveillance, Center for Cancer Control and Information Service,
      National Cancer Center, Tokyo, Japan.
FAU - Ito, Hidemi
AU  - Ito H
AUID- ORCID: http://orcid.org/0000-0002-8023-4581
AD  - Division of Cancer Information and Control, Department of Preventive Medicine,
      Aichi Cancer Center Research Institute, 1-1 Kanokoden Chikusa-ku, Nagoya, Aichi, 
      464-8681, Japan. hidemi@aichi-cc.jp.
AD  - Department of Epidemiology, Nagoya University Graduate School of Medicine,
      Nagoya, Japan. hidemi@aichi-cc.jp.
LA  - eng
GR  - H29-political-general-016/Ministry of Health, Labour and Welfare
GR  - H29-political-general-015/Ministry of Health, Labour and Welfare
GR  - 17K15840/Japan Society for the Promotion of Science
PT  - Journal Article
DEP - 20190509
PL  - England
TA  - BMC Cancer
JT  - BMC cancer
JID - 100967800
PMC - PMC6509813
OTO - NOTNLM
OT  - Anatomical subsite
OT  - Colorectal cancer
OT  - Net survival
OT  - Population-based cancer registries
EDAT- 2019/05/11 06:00
MHDA- 2019/05/11 06:00
CRDT- 2019/05/11 06:00
PHST- 2018/08/07 00:00 [received]
PHST- 2019/04/26 00:00 [accepted]
PHST- 2019/05/11 06:00 [entrez]
PHST- 2019/05/11 06:00 [pubmed]
PHST- 2019/05/11 06:00 [medline]
AID - 10.1186/s12885-019-5644-y [doi]
AID - 10.1186/s12885-019-5644-y [pii]
PST - epublish
SO  - BMC Cancer. 2019 May 9;19(1):431. doi: 10.1186/s12885-019-5644-y.