PMID- 31012957
OWN - NLM
STAT- Publisher
LR  - 20190426
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Linking)
DP  - 2019 Apr 23
TI  - Survival outcomes by high-risk human papillomavirus status in nonoropharyngeal
      head and neck squamous cell carcinomas: A propensity-scored analysis of the
      National Cancer Data Base.
LID - 10.1002/cncr.32115 [doi]
AB  - BACKGROUND: The prognostic relevance of human papillomavirus (HPV) status in
      patients with nonoropharyngeal (OPX) squamous cell cancer (SCC) of the head and
      neck is controversial. In the current study, the authors evaluated the impact of 
      high-risk HPV status on overall survival (OS) in patients with non-OPX SCC using 
      a large database approach. METHODS: The National Cancer Data Base was queried to 
      identify patients diagnosed from 2004 through 2014 with SCC of the OPX,
      hypopharynx (HPX), larynx, and oral cavity (OC) with known HPV status. Survival
      was estimated using Kaplan-Meier methods; distributions were compared using
      log-rank tests. Propensity score-matching and inverse probability of treatment
      weighing (IPTW) methods were used; cohorts were matched based on age, sex,
      Charlson-Deyo score, clinical American Joint Committee on Cancer (AJCC) group
      stage, treatments received, and anatomic subsite. Propensity analyses were
      stratified by group stage of disease. RESULTS: A total of 24,740 patients
      diagnosed from 2010 through 2013 were analyzed: 1085 patients with HPX, 4804 with
      laryngeal, 4,018 with OC, and 14,833 with OPX SCC. The percentages of
      HPV-positive cases by disease site were 17.7% for HPX, 11% for larynx, 10.6% for 
      OC, and 62.9% for OPX. HPV status was found to be prognostic in multiple
      unadjusted and propensity-adjusted non-OPX populations. HPV positivity was
      associated with superior OS in patients with HPX SCC with a hazard ratio (HR) of 
      0.61 (P < .001 by IPTW), in patients with AJCC stage III to IVB laryngeal SCC
      (HR, 0.79; P = .019 by IPTW), and in patients with AJCC stage III to IVB OC SCC
      (HR, 0.78; P = .03 by IPTW). CONCLUSIONS: Positive high-risk HPV status appears
      to be associated with longer OS in multiple populations of patients with non-OPX 
      head and neck disease (HPX, locally advanced larynx, and OC). If prospectively
      validated, these findings have implications for risk stratification.
CI  - (c) 2019 American Cancer Society.
FAU - Tian, Sibo
AU  - Tian S
AUID- ORCID: https://orcid.org/0000-0001-5018-4854
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Switchenko, Jeffrey M
AU  - Switchenko JM
AD  - Department of Biostatistics and Bioinformatics, Rollins School of Public Heath,
      Emory University, Atlanta, Georgia.
FAU - Jhaveri, Jaymin
AU  - Jhaveri J
AUID- ORCID: https://orcid.org/0000-0002-7594-4407
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Cassidy, Richard J
AU  - Cassidy RJ
AUID- ORCID: https://orcid.org/0000-0003-0019-0679
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Ferris, Matthew J
AU  - Ferris MJ
AUID- ORCID: https://orcid.org/0000-0001-6605-2071
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Press, Robert H
AU  - Press RH
AUID- ORCID: https://orcid.org/0000-0002-3297-3945
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Pfister, Neil T
AU  - Pfister NT
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Patel, Mihir R
AU  - Patel MR
AUID- ORCID: https://orcid.org/0000-0001-6477-9728
AD  - Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta,
      Georgia.
FAU - Saba, Nabil F
AU  - Saba NF
AUID- ORCID: https://orcid.org/0000-0003-4972-1477
AD  - Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory
      University, Atlanta, Georgia.
FAU - McDonald, Mark W
AU  - McDonald MW
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Higgins, Kristin A
AU  - Higgins KA
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Yu, David S
AU  - Yu DS
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Curran, Walter J
AU  - Curran WJ
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
FAU - Gillespie, Theresa W
AU  - Gillespie TW
AD  - Department of Surgery, Winship Cancer Institute, Emory University, Atlanta,
      Georgia.
FAU - Beitler, Jonathan J
AU  - Beitler JJ
AUID- ORCID: https://orcid.org/0000-0002-1519-2071
AD  - Department of Radiation Oncology, Winship Cancer Institute, Emory University,
      Atlanta, Georgia.
AD  - Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta,
      Georgia.
AD  - Department of Surgery, Winship Cancer Institute, Emory University, Atlanta,
      Georgia.
LA  - eng
GR  - U10 CA180864/CA/NCI NIH HHS/United States
GR  - UG1 CA233247/CA/NCI NIH HHS/United States
GR  - P30CA138292/National Cancer Institute
PT  - Journal Article
DEP - 20190423
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
OTO - NOTNLM
OT  - National Cancer Data Base
OT  - biomarker
OT  - head and neck cancer
OT  - human papillomavirus (HPV)
OT  - hypopharynx
OT  - larynx
OT  - oral cavity
OT  - p16
EDAT- 2019/04/24 06:00
MHDA- 2019/04/24 06:00
CRDT- 2019/04/24 06:00
PHST- 2018/11/12 00:00 [received]
PHST- 2019/02/22 00:00 [revised]
PHST- 2019/03/05 00:00 [accepted]
PHST- 2019/04/24 06:00 [entrez]
PHST- 2019/04/24 06:00 [pubmed]
PHST- 2019/04/24 06:00 [medline]
AID - 10.1002/cncr.32115 [doi]
PST - aheadofprint
SO  - Cancer. 2019 Apr 23. doi: 10.1002/cncr.32115.