PMID- 30952765
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20190415
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 39
IP  - 4
DP  - 2019 Apr
TI  - Association of Statin Use and Oncological Outcomes After Neoadjuvant Radiotherapy
      in Patients With Rectal Cancer.
PG  - 2177-2182
LID - 10.21873/anticanres.13332 [doi]
AB  - AIM: The aim of the study was to examine if statin exposure during neoadjuvant
      chemoradiotherapy improves oncological outcomes in patients with rectal cancer.
      PATIENTS AND METHODS: The study cohort consisted of patients who were undergoing 
      neoadjuvant chemoradiotherapy and resection for rectal cancer. The statin users
      were matched 1:1 with non-users using propensity score-based matching. The
      primary outcome of the study was disease-free survival; secondary outcomes were
      recurrence-free survival and all-cause mortality. RESULTS: A total of 704
      patients were included in the study. Disease-free survival was not different
      between the two groups [hazard ratio (HR)=0.98, 95% confidence intervaI
      (CI)=0.77-1.25, p=0.88]. Both recurrence-free survival (HR=1.02, 95%
      CI=0.74-1.39, p=0.92) and all-cause mortality (HR=0.92, 95% CI=0.68-1.23, p=0.56)
      were similar for the two groups. CONCLUSION: The study does not support that
      statin use is associated with response to neoadjuvant chemoradiotherapy in terms 
      of disease-free survival, recurrence-free survival or all-cause mortality.
CI  - Copyright(c) 2019, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Fransgaard, Tina
AU  - Fransgaard T
AD  - Department of Surgery, Zealand University Hospital, Koge, Denmark
      tifer@regionsjaelland.dk.
FAU - Hallas, Jesper
AU  - Hallas J
AD  - Clinical Pharmacology and Pharmacy, University of Southern Denmark, Odense,
      Denmark.
FAU - Thygesen, Lau Caspar
AU  - Thygesen LC
AD  - National Institute of Public Health, University of Southern Denmark, Copenhagen, 
      Denmark.
FAU - Gogenur, Ismail
AU  - Gogenur I
AD  - Department of Surgery, Zealand University Hospital, Koge, Denmark.
AD  - Institute for Clinical Medicine, Copenhagen University, Copenhagen, Denmark.
AD  - Danish Colorectal Cancer Group, Copenhagen, Denmark.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chemoradiotherapy
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - *Neoadjuvant Therapy
MH  - Rectal Neoplasms/*mortality/*therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Rectal cancer
OT  - chemoradiotherapy
OT  - statins
EDAT- 2019/04/07 06:00
MHDA- 2019/04/16 06:00
CRDT- 2019/04/07 06:00
PHST- 2019/01/26 00:00 [received]
PHST- 2019/02/23 00:00 [revised]
PHST- 2019/02/26 00:00 [accepted]
PHST- 2019/04/07 06:00 [entrez]
PHST- 2019/04/07 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
AID - 39/4/2177 [pii]
AID - 10.21873/anticanres.13332 [doi]
PST - ppublish
SO  - Anticancer Res. 2019 Apr;39(4):2177-2182. doi: 10.21873/anticanres.13332.