PMID- 30932887
OWN - NLM
STAT- In-Data-Review
LR  - 20190429
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 68
IP  - 4
DP  - 2019
TI  - "To Treat or not To Treat": Informing the Decision for Disease-Modifying Therapy 
      in Late-Stage Alzheimer's Disease.
PG  - 1321-1323
LID - 10.3233/JAD-190033 [doi]
AB  - Rosen et al. thoughtfully extend the ethical discussion surrounding
      disease-modifying therapies in late-stage Alzheimer's disease (AD) to correctly
      emphasize that the perceived quality of life (QoL) of the individual living with 
      the disease is a critical component to decisions regarding their clinical care.
      The primary purpose of our original article regarding the use of
      disease-modifying therapeutics in late-stage AD was to ensure that those affected
      by AD and their primary care team are empowered to make informed care decisions
      in the best interest of the individual living with AD. Consequently, it appears
      axiomatic that major therapeutic decisions need to incorporate consideration of
      the current and future QoL of individuals living with dementia; however, in the
      absence of effective restorative therapies, it is important to acknowledge the
      context within which extant QoL measures were developed and question whether such
      measures are adequate to inform treatment decisions that may hold the potential
      to significantly or perhaps indefinitely prolong severe disability.
FAU - Watt, Andrew D
AU  - Watt AD
AD  - The Department of Pharmacology and Therapeutics, University of Melbourne,
      Melbourne, VIC, Australia.
FAU - Jenkins, Nicole L
AU  - Jenkins NL
AD  - Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and
      Mental Health, University of Melbourne, Melbourne, VIC, Australia.
FAU - McColl, Gawain
AU  - McColl G
AD  - Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and
      Mental Health, University of Melbourne, Melbourne, VIC, Australia.
FAU - Collins, Steven
AU  - Collins S
AD  - Department of Medicine (RMH), University of Melbourne, Melbourne, VIC, Australia.
FAU - Desmond, Patricia M
AU  - Desmond PM
AD  - Department of Medicine and Radiology, Royal Melbourne Hospital, University of
      Melbourne, Melbourne, VIC, Australia.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - ethics
OT  - late-stage
OT  - quality of life
OT  - restoration
OT  - therapeutics
EDAT- 2019/04/02 06:00
MHDA- 2019/04/02 06:00
CRDT- 2019/04/02 06:00
PHST- 2019/04/02 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2019/04/02 06:00 [entrez]
AID - JAD190033 [pii]
AID - 10.3233/JAD-190033 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2019;68(4):1321-1323. doi: 10.3233/JAD-190033.