PMID- 30912096
OWN - NLM
STAT- In-Process
LR  - 20190610
IS  - 1098-8971 (Electronic)
IS  - 0272-8087 (Linking)
VI  - 39
IP  - 2
DP  - 2019 May
TI  - Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis.
PG  - 235-248
LID - 10.1055/s-0039-1681032 [doi]
AB  - Endoplasmic reticulum (ER) stress is a major contributor to liver disease and
      hepatic fibrosis, but the role it plays varies depending on the cause and
      progression of the disease. Furthermore, ER stress plays a distinct role in
      hepatocytes versus hepatic stellate cells (HSCs), which adds to the complexity of
      understanding ER stress and its downstream signaling through the unfolded protein
      response (UPR) in liver disease. Here, the authors focus on the current
      literature of ER stress in nonalcoholic and alcoholic fatty liver diseases, how
      ER stress impacts hepatocyte injury, and the role of ER stress in HSC activation 
      and hepatic fibrosis. This review provides insight into the complex signaling and
      regulation of the UPR, parallels and distinctions between different liver
      diseases, and how ER stress may be targeted as an antisteatotic or antifibrotic
      therapy to limit the progression of liver disease.
CI  - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
FAU - Maiers, Jessica L
AU  - Maiers JL
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
FAU - Malhi, Harmeet
AU  - Malhi H
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
LA  - eng
GR  - K01 DK112915/DK/NIDDK NIH HHS/United States
GR  - R01 DK111378/DK/NIDDK NIH HHS/United States
GR  - NIH/DK111378, DK112915
PT  - Journal Article
DEP - 20190325
PL  - United States
TA  - Semin Liver Dis
JT  - Seminars in liver disease
JID - 8110297
SB  - IM
PMC - PMC6530577
MID - NIHMS1028647
COIS- None.
EDAT- 2019/03/27 06:00
MHDA- 2019/03/27 06:00
CRDT- 2019/03/27 06:00
PHST- 2019/03/27 06:00 [pubmed]
PHST- 2019/03/27 06:00 [medline]
PHST- 2019/03/27 06:00 [entrez]
AID - 10.1055/s-0039-1681032 [doi]
PST - ppublish
SO  - Semin Liver Dis. 2019 May;39(2):235-248. doi: 10.1055/s-0039-1681032. Epub 2019
      Mar 25.