PMID- 30831446
OWN - NLM
STAT- MEDLINE
DCOM- 20190725
LR  - 20190725
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 235
DP  - 2019 Apr
TI  - Prophylaxis of peripartum haemorrhage using recombinant factor VIIa (rfVIIa) in
      pregnant women with congenital factor VII deficiency: A case report and
      literature review.
PG  - 77-80
LID - S0301-2115(19)30084-3 [pii]
LID - 10.1016/j.ejogrb.2019.02.017 [doi]
AB  - Congenital factor VII deficiency is a rare autosomal recessive disorder
      associated to different haemorrhagic manifestations. Labour and delivery may
      cause bleeding risk in patients with this coagulation deficit, thus it is
      appropriate to clarify whether prophylaxis of peripartum haemorrhage is
      necessary. To date, there are very few cases in scientific literature which
      report the management of women with congenital factor VII deficiency during
      labour, and a consensus for prophylaxis does not exist. In this manuscript we
      present the management of a 35 years old woman with factor VII deficiency,
      treated with recombinant factor VIIa before delivery, without haemorrhagic
      complications either for the woman and for the infant. Therefore, we present a
      review of similar cases managed with a peripartum prophylaxis with recombinant
      factor VIIa, and discuss its usefulness and effectiveness, in view of the
      severity of the deficit and the doses used.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Loddo, Alessandro
AU  - Loddo A
AD  - Department of Surgical Sciences, Clinic of Obstetrics and Gynecology, University 
      Hospital of Cagliari, Italy. Electronic address: alessandroloddo@gmail.com.
FAU - Cornacchia, Stefania
AU  - Cornacchia S
AD  - Department of Surgical Sciences, Clinic of Obstetrics and Gynecology, University 
      Hospital of Cagliari, Italy.
FAU - Cane, Fiorenza Lo
AU  - Cane FL
AD  - Department of Surgical Sciences, Clinic of Obstetrics and Gynecology, University 
      Hospital of Cagliari, Italy.
FAU - Barcellona, Doris
AU  - Barcellona D
AD  - Internal Medicine and Haemocoagulopathies Unit, University of Cagliari, Italy.
FAU - Marongiu, Francesco
AU  - Marongiu F
AD  - Internal Medicine and Haemocoagulopathies Unit, University of Cagliari, Italy.
FAU - Melis, Gian Benedetto
AU  - Melis GB
AD  - Department of Surgical Sciences, Clinic of Obstetrics and Gynecology, University 
      Hospital of Cagliari, Italy.
FAU - Angioni, Stefano
AU  - Angioni S
AD  - Department of Surgical Sciences, Clinic of Obstetrics and Gynecology, University 
      Hospital of Cagliari, Italy.
FAU - Paoletti, Anna Maria
AU  - Paoletti AM
AD  - Department of Surgical Sciences, Clinic of Obstetrics and Gynecology, University 
      Hospital of Cagliari, Italy.
FAU - Neri, Manuela
AU  - Neri M
AD  - Department of Surgical Sciences, Clinic of Obstetrics and Gynecology, University 
      Hospital of Cagliari, Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20190222
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
RN  - 0 (Recombinant Proteins)
RN  - AC71R787OV (recombinant FVIIa)
RN  - EC 3.4.21.21 (Factor VIIa)
MH  - Adult
MH  - Factor VII Deficiency/congenital/*drug therapy
MH  - Factor VIIa/*therapeutic use
MH  - Female
MH  - Hemorrhage/congenital/*prevention & control
MH  - Humans
MH  - Peripartum Period
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/*drug therapy/*prevention & control
MH  - Recombinant Proteins/therapeutic use
OTO - NOTNLM
OT  - Coagulation disorders in pregnancy
OT  - Factor VII deficiency
OT  - Peripartum haemorrhage
OT  - Recombinant factor VIIa
EDAT- 2019/03/05 06:00
MHDA- 2019/07/26 06:00
CRDT- 2019/03/05 06:00
PHST- 2018/10/10 00:00 [received]
PHST- 2019/02/04 00:00 [revised]
PHST- 2019/02/17 00:00 [accepted]
PHST- 2019/03/05 06:00 [pubmed]
PHST- 2019/07/26 06:00 [medline]
PHST- 2019/03/05 06:00 [entrez]
AID - S0301-2115(19)30084-3 [pii]
AID - 10.1016/j.ejogrb.2019.02.017 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2019 Apr;235:77-80. doi:
      10.1016/j.ejogrb.2019.02.017. Epub 2019 Feb 22.