PMID- 30824652
OWN - NLM
STAT- Publisher
LR  - 20190302
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
DP  - 2019 Mar 1
TI  - In rheumatoid arthritis fewer women breastfeed their offspring compared with
      women from the general population; results from a nationwide prospective cohort
      study.
LID - jrheum.180805 [pii]
LID - 10.3899/jrheum.180805 [doi]
AB  - OBJECTIVE: The World Health Organization recommends to exclusively breastfeed
      infants until the age of six months. The first objective was to compare
      breastfeeding frequencies and time of cessation between women with rheumatoid
      arthritis(RA) and the general population. Second, to identify why patients with
      RA discontinue breastfeeding. METHODS: This study was embedded in the Pregnancy
      induced Amelioration of Rheumatoid Arthritis study, a nationwide prospective
      cohort study. From 2002-2008 in total 249 pregnancies were followed from
      pregnancy until 6 months postpartum. Data on lactation and medication use were
      collected. Proportion tests were used to compare percentages of breastfeeding
      between the study population and the general/reference population. RESULTS: At
      4-6, 12 and 26 weeks postpartum 43%, 26% and 9% of the RA patients breastfed
      their offsprings respectively, compared with 63%, 46% and 41% in the general
      population(pvalues < 0.001). The main reason for women to discontinue
      breastfeeding was the restart of medication(n=129, 58.6%). Nevertheless, more
      than 40% of these patients restarted medication that was considered compatible
      with breastfeeding. CONCLUSION: This large prospective study demonstrates that RA
      is associated with lower proportions of women breastfeeding their offspring and
      earlier cessation compared with the general population. A considerable amount of 
      patients discontinue breastfeeding so that they could start medication, despite
      the fact that many of the medications are considered safe to use during
      lactation. Using the results of this study, intervention strategies supporting RA
      patients who wish to breastfeed may be developed.
FAU - Ince-Askan, Hilal
AU  - Ince-Askan H
AD  - From the Department of Rheumatology, Erasmus Medical Center, Rotterdam, The
      Netherlands. This study was funded by the Dutch Arthritis Association
      (Reumafonds), a noncommercial fund raising organisation. Dr. R.J.E.M. Dolhain
      received an unrestricted grant from UCB Pharma B.V. Address correspondence Hilal 
      Ince-Askan, MD, Erasmus MC, department of Rheumatology, Room Na-523, PO box 2040,
      3000 CA Rotterdam, The Netherlands. E-mail: h.ince-askan@erasmusmc.nl.
FAU - Hazes, Johanna M W
AU  - Hazes JMW
AD  - From the Department of Rheumatology, Erasmus Medical Center, Rotterdam, The
      Netherlands. This study was funded by the Dutch Arthritis Association
      (Reumafonds), a noncommercial fund raising organisation. Dr. R.J.E.M. Dolhain
      received an unrestricted grant from UCB Pharma B.V. Address correspondence Hilal 
      Ince-Askan, MD, Erasmus MC, department of Rheumatology, Room Na-523, PO box 2040,
      3000 CA Rotterdam, The Netherlands. E-mail: h.ince-askan@erasmusmc.nl.
FAU - Dolhain, Radboud J E M
AU  - Dolhain RJEM
AD  - From the Department of Rheumatology, Erasmus Medical Center, Rotterdam, The
      Netherlands. This study was funded by the Dutch Arthritis Association
      (Reumafonds), a noncommercial fund raising organisation. Dr. R.J.E.M. Dolhain
      received an unrestricted grant from UCB Pharma B.V. Address correspondence Hilal 
      Ince-Askan, MD, Erasmus MC, department of Rheumatology, Room Na-523, PO box 2040,
      3000 CA Rotterdam, The Netherlands. E-mail: h.ince-askan@erasmusmc.nl.
LA  - eng
PT  - Journal Article
DEP - 20190301
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
EDAT- 2019/03/03 06:00
MHDA- 2019/03/03 06:00
CRDT- 2019/03/03 06:00
PHST- 2019/03/03 06:00 [entrez]
PHST- 2019/03/03 06:00 [pubmed]
PHST- 2019/03/03 06:00 [medline]
AID - jrheum.180805 [pii]
AID - 10.3899/jrheum.180805 [doi]
PST - aheadofprint
SO  - J Rheumatol. 2019 Mar 1. pii: jrheum.180805. doi: 10.3899/jrheum.180805.