PMID- 30810911
OWN - NLM
STAT- Publisher
LR  - 20190227
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
DP  - 2019 Feb 27
TI  - Diagnostic accuracy of anti-keratin antibody for rheumatoid arthritis: a
      meta-analysis.
LID - 10.1007/s10067-019-04464-x [doi]
AB  - OBJECTIVES: Anti-keratin antibody (AKA) is a serum antibody for patients with
      rheumatoid arthritis (RA), and it has a high specificity. Diagnostic role of AKA 
      in RA was evaluated in this study. METHODS: PubMed, EMBASE, and Web of Science
      were searched to acquire eligible studies. Articles published before 15 March
      2018 were considered to be included. Quality Assessment of Diagnostic Accuracy
      Studies 2 was used to evaluate the risk of bias and application concern of the
      included articles. Pooled analysis of diagnostic indicators of AKA for RA was
      conducted by using a random effects model. Subgroup analysis was employed to
      explore the potential influencing factors. RevMan 5.3, Stata 11.0, and Meta-DiSc 
      1.4 software were used in this study. RESULTS: A total of 15 studies (2350
      positive and 2067 negative participants) were included. The pooled sensitivity
      was 0.46 (95% CI 0.44-0.48), pooled specificity was 0.94 (95% CI 0.93-0.95), and 
      pooled diagnostic odds ratio was 15.86 (95% CI 9.48-26.52). In addition, the area
      under the curve was 0.7194. CONCLUSIONS: The current evidence indicated that AKA 
      has high diagnostic specificity in RA and may be useful for RA diagnostic
      application in clinic.
FAU - Wang, Xue-Ping
AU  - Wang XP
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui
      Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road,
      Hefei, 230032, Anhui, China.
FAU - Cheng, Qian-Yao
AU  - Cheng QY
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui
      Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road,
      Hefei, 230032, Anhui, China.
FAU - Gu, Ming-Ming
AU  - Gu MM
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui
      Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road,
      Hefei, 230032, Anhui, China.
FAU - Leng, Rui-Xue
AU  - Leng RX
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui
      Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road,
      Hefei, 230032, Anhui, China.
FAU - Fan, Yin-Guang
AU  - Fan YG
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui
      Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road,
      Hefei, 230032, Anhui, China.
FAU - Li, Bao-Zhu
AU  - Li BZ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui
      Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
      libaozhu@ahmu.edu.cn.
AD  - Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road,
      Hefei, 230032, Anhui, China. libaozhu@ahmu.edu.cn.
FAU - Ye, Dong-Qing
AU  - Ye DQ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui
      Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
      ydqahmu@126.com.
AD  - Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road,
      Hefei, 230032, Anhui, China. ydqahmu@126.com.
LA  - eng
GR  - 81473058/National Natural Science Foundation of China
GR  - XJ201619/the Doctoral Research Foundation of Anhui Medical University
PT  - Journal Article
DEP - 20190227
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
OTO - NOTNLM
OT  - Anti-keratin antibody (AKA)
OT  - Diagnostic
OT  - Meta-analysis
OT  - Rheumatoid arthritis (RA)
EDAT- 2019/02/28 06:00
MHDA- 2019/02/28 06:00
CRDT- 2019/02/28 06:00
PHST- 2018/07/28 00:00 [received]
PHST- 2019/02/03 00:00 [accepted]
PHST- 2018/12/11 00:00 [revised]
PHST- 2019/02/28 06:00 [entrez]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2019/02/28 06:00 [medline]
AID - 10.1007/s10067-019-04464-x [doi]
AID - 10.1007/s10067-019-04464-x [pii]
PST - aheadofprint
SO  - Clin Rheumatol. 2019 Feb 27. pii: 10.1007/s10067-019-04464-x. doi:
      10.1007/s10067-019-04464-x.