PMID- 30809736
OWN - NLM
STAT- Publisher
LR  - 20190227
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
DP  - 2019 Feb 26
TI  - Prevalence of frailty and its associated factors in patients with rheumatoid
      arthritis: a cross-sectional analysis.
LID - 10.1007/s10067-019-04486-5 [doi]
AB  - OBJECTIVES: The aims of the present research were to assess the prevalence of
      frailty and its potential associated factors in a cohort of adult patients with
      rheumatoid arthritis (RA). METHODS: Consecutive RA patients and healthy controls 
      were assessed according to the Survey of Health, Ageing and Retirement in Europe 
      Frailty Instrument (SHARE-FI), and classified as frail, pre-frail, or non-frail. 
      Chi-square, analysis of variance (ANOVA), and multinomial logistic regression
      analyses were used to test the prognostic value of frailty for the outcomes of
      interest. RESULTS: Two hundred and ten consecutive RA patients (65.7% female,
      mean age 60.4 years) and 100 healthy controls (63% female, mean age 59.1 years)
      were included. According to SHARE-FI criteria, 35 RA patients (16.6%) were
      categorized as frail, 68 (32.4%) as pre-frail, and 107 (51%) as non-frail, while 
      8 control subjects were categorized as frail, (8%), 17 as pre-frail (17%), and 75
      as non-frail (75%) (chi-squared 12.8; P = 0.0016). The results from logistic
      regression analysis revealed that age (odds ratio [OR] = 1.12, 95% confidence
      interval [CI] = 1.07-1.17; P < 0.0001), comorbidities (OR = 1.51, 95% CI =
      1.01-2.27; P = 0.0446), and high disease activity (OR = 1.10, 95% CI = 1.04-1.16;
      P = 0.0006) were independently associated with frailty in RA. CONCLUSIONS:
      Frailty or pre-frailty are common in RA. The SHARE-FI may be a useful tool for
      the screening of frailty in RA and may summarize the results of a comprehensive
      RA assessment providing a marker of deficits accumulation.
FAU - Salaffi, Fausto
AU  - Salaffi F
AD  - Rheumatological Clinic, Ospedale "Carlo Urbani", Universita Politecnica delle
      Marche, Via Aldo Moro, 25, Jesi, Ancona, Italy.
FAU - Di Carlo, Marco
AU  - Di Carlo M
AUID- ORCID: http://orcid.org/0000-0002-0906-4647
AD  - Rheumatological Clinic, Ospedale "Carlo Urbani", Universita Politecnica delle
      Marche, Via Aldo Moro, 25, Jesi, Ancona, Italy. dica.marco@yahoo.it.
FAU - Farah, Sonia
AU  - Farah S
AD  - Rheumatological Clinic, Ospedale "Carlo Urbani", Universita Politecnica delle
      Marche, Via Aldo Moro, 25, Jesi, Ancona, Italy.
FAU - Di Donato, Eleonora
AU  - Di Donato E
AD  - Rheumatological Clinic, Ospedale "Carlo Urbani", Universita Politecnica delle
      Marche, Via Aldo Moro, 25, Jesi, Ancona, Italy.
FAU - Carotti, Marina
AU  - Carotti M
AD  - Department of Radiology, Ospedali Riuniti, Universita Politecnica delle Marche,
      Ancona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190226
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
OTO - NOTNLM
OT  - Comorbidities
OT  - Frailty syndrome
OT  - Grip strength
OT  - Rheumatoid arthritis
OT  - SHARE-FI
EDAT- 2019/02/28 06:00
MHDA- 2019/02/28 06:00
CRDT- 2019/02/28 06:00
PHST- 2018/11/28 00:00 [received]
PHST- 2019/02/17 00:00 [accepted]
PHST- 2019/02/13 00:00 [revised]
PHST- 2019/02/28 06:00 [entrez]
PHST- 2019/02/28 06:00 [pubmed]
PHST- 2019/02/28 06:00 [medline]
AID - 10.1007/s10067-019-04486-5 [doi]
AID - 10.1007/s10067-019-04486-5 [pii]
PST - aheadofprint
SO  - Clin Rheumatol. 2019 Feb 26. pii: 10.1007/s10067-019-04486-5. doi:
      10.1007/s10067-019-04486-5.