PMID- 30801711
OWN - NLM
STAT- In-Process
LR  - 20190404
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 145
IP  - 2
DP  - 2019 May
TI  - Relationships of serum placental growth factor and soluble fms-like tyrosine
      kinase-1 with fetal and uterine artery Doppler indices in pre-eclampsia.
PG  - 176-181
LID - 10.1002/ijgo.12796 [doi]
AB  - OBJECTIVE: To compare serum placental growth factor (PlGF) and soluble fms-like
      tyrosine kinase-1 (sFlt-1) concentrations among women with pre-eclampsia and
      healthy control women and to evaluate the associations of serum PlGF and sFlt-1
      with fetal and uterine artery Doppler indices in pre-eclampsia. METHODS: A
      prospective cross-sectional study of 33 women with pre-eclampsia and 33
      normotensive pregnant women attending a university hospital in China between
      January and November 2014. Serum PlGF and sFlt-1 were assayed by enzyme linked
      immunosorbent assays. Doppler indices of the uterine artery, umbilical artery,
      fetal middle cerebral artery, and ductus venosus were measured. RESULTS: The
      pulsatility index of the uterine artery was negatively correlated with PlGF (r,
      -0.487; P=0.004) and positively correlated with sFlt-1 (r, 0.420; P=0.015).
      Gestational age at birth was positively correlated with PlGF (r, 0.601, P<0.001) 
      and negatively correlated with sFlt-1 (r, -0.568; P=0.001). Birth weight was
      positively correlated with PlGF (r, 0.555; P=0.001) and negatively correlated
      with sFlt-1 (r, -0.552; P=0.001). Apgar score was negatively correlated with
      sFlt-1 (r, -0.427; P=0.017). CONCLUSION: Lower PlGF and higher sFlt-1 levels in
      maternal serum were significantly associated with increased uterine arterial
      impedance in pre-eclampsia.
CI  - (c) 2019 International Federation of Gynecology and Obstetrics.
FAU - Li, Jingyu
AU  - Li J
AD  - Department of Ultrasound, Shengjing Hospital of China Medical University,
      Shenyang, Liaoning, China.
FAU - Cai, Ailu
AU  - Cai A
AD  - Department of Ultrasound, Shengjing Hospital of China Medical University,
      Shenyang, Liaoning, China.
FAU - Yuan, Qian
AU  - Yuan Q
AD  - Department of Ultrasound, Shengjing Hospital of China Medical University,
      Shenyang, Liaoning, China.
FAU - Ding, Hao
AU  - Ding H
AD  - Department of Ultrasound, Shengjing Hospital of China Medical University,
      Shenyang, Liaoning, China.
FAU - Zhao, Dan
AU  - Zhao D
AD  - Department of Ultrasound, Shengjing Hospital of China Medical University,
      Shenyang, Liaoning, China.
LA  - eng
PT  - Journal Article
DEP - 20190313
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
OTO - NOTNLM
OT  - Fetal Doppler
OT  - Placental growth factor
OT  - Pre-eclampsia
OT  - Serum biomarkers
OT  - Soluble fms-like tyrosine kinase-1
OT  - Uterine artery Doppler
EDAT- 2019/02/26 06:00
MHDA- 2019/02/26 06:00
CRDT- 2019/02/26 06:00
PHST- 2018/06/17 00:00 [received]
PHST- 2018/10/30 00:00 [revised]
PHST- 2019/02/21 00:00 [accepted]
PHST- 2019/02/26 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
PHST- 2019/02/26 06:00 [entrez]
AID - 10.1002/ijgo.12796 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2019 May;145(2):176-181. doi: 10.1002/ijgo.12796. Epub
      2019 Mar 13.