PMID- 30799358
OWN - NLM
STAT- Publisher
LR  - 20190225
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
DP  - 2019 Feb 25
TI  - Effect of Biological Disease-modifying Anti-rheumatic Drugs on Airway and
      Interstitial Lung Disease in Patients with Rheumatoid Arthritis.
LID - 10.2169/internalmedicine.2226-18 [doi]
AB  - Objective Biological disease-modifying anti-rheumatic drugs (bDMARDs) represent
      an important advance in alleviating rheumatoid arthritis (RA), but their effect
      on rheumatic airway disease (AD) and interstitial lung disease (ILD) is still
      unclear. This study was performed to evaluate the association of the use of
      different bDMARDs with new-onset or worsening of RA-AD/ILD. Methods We performed 
      a retrospective cohort study of RA patients who received bDMARDs and assessed
      their AD/ILD before and after drug initiation in our hospital over the past 10
      years. We evaluated the serial changes in computed tomography (CT), classified
      patients according to AD/ILD progression, and analyzed associations between
      clinical characteristics and outcomes. Results We enrolled 49 patients. Thirty
      patients received tumor necrosis factor inhibitors (TNFis), 12 received abatacept
      (ABT), and the remaining 7 received tocilizumab (TCZ). Seventeen patients had
      ILD, 10 had AD, and 6 had both AD and ILD before the initiation of bDMARDs. New
      emergence or exacerbation of AD/ILD was observed in 18 patients after drug
      initiation, while the remaining 31 remained stable or improved. Multiple logistic
      regression analyses revealed that pre-existing AD was an independent risk factor 
      against the emergence or exacerbation of RA-AD/ILD, and ABT use was a protective 
      factor against it. Conclusion Our study showed that pre-existing RA-AD is
      associated with future worsening of RA-AD/ILD, and ABT over other bDMARDs was
      associated with a better prognosis. Future studies to confirm our results are
      needed.
FAU - Kurata, Izumi
AU  - Kurata I
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Tsuboi, Hiroto
AU  - Tsuboi H
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Terasaki, Mayu
AU  - Terasaki M
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Shimizu, Masaru
AU  - Shimizu M
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Toko, Hirofumi
AU  - Toko H
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Honda, Fumika
AU  - Honda F
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Ohyama, Ayako
AU  - Ohyama A
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Yagishita, Mizuki
AU  - Yagishita M
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Osada, Atsumu
AU  - Osada A
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Ebe, Hiroshi
AU  - Ebe H
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Kawaguchi, Hoshimi
AU  - Kawaguchi H
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Takahashi, Hiroyuki
AU  - Takahashi H
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Hagiwara, Shinya
AU  - Hagiwara S
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Asashima, Hiromitsu
AU  - Asashima H
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Kondo, Yuya
AU  - Kondo Y
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Matsumoto, Isao
AU  - Matsumoto I
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
FAU - Sumida, Takayuki
AU  - Sumida T
AD  - Department of Internal Medicine, Faculty of Medicine, University of Tsukuba,
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20190225
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
OTO - NOTNLM
OT  - abatacept
OT  - airway disease
OT  - biological DMARDs
OT  - interstitial lung disease
OT  - rheumatoid arthritis
EDAT- 2019/02/26 06:00
MHDA- 2019/02/26 06:00
CRDT- 2019/02/26 06:00
PHST- 2019/02/26 06:00 [entrez]
PHST- 2019/02/26 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
AID - 10.2169/internalmedicine.2226-18 [doi]
PST - aheadofprint
SO  - Intern Med. 2019 Feb 25. doi: 10.2169/internalmedicine.2226-18.