PMID- 30789411
OWN - NLM
STAT- In-Data-Review
LR  - 20190325
IS  - 1537-453X (Electronic)
IS  - 0277-3732 (Linking)
VI  - 42
IP  - 4
DP  - 2019 Apr
TI  - Effects of Social and Contextual Factors Including Marital Status and Children on
      the Use of Palliative Chemotherapy in Metastatic Colorectal Cancer.
PG  - 363-366
LID - 10.1097/COC.0000000000000530 [doi]
AB  - BACKGROUND: There is evidence that social and contextual factors such as living
      alone are associated with outcomes in cancer patients. However, little is known
      about their influence on the use of palliative chemotherapy in metastatic
      colorectal cancer (mCRC). In this study, we examined social and contextual
      factors, including marital status, having children, and distance to a cancer
      center, for their association with the use of chemotherapy in patients with mCRC.
      METHODS: A cohort of patients with mCRC diagnosed from 2006 to 2010 in
      Saskatchewan was evaluated. Logistic regression analyses were performed to assess
      the relationship between the variables and use of chemotherapy. RESULTS: Of 569
      patients, 326 (57%) received chemotherapy significant differences were noted
      between the chemotherapy versus no chemotherapy groups with respect to age (62
      vs. 76 y), poor performance status (18% vs. 58%), comorbid illness (24% vs. 63%),
      low albumin (61% vs. 89%), anemia (61% vs. 87%), elevated alkaline phosphatase
      (53% vs. 84%), elevated creatinine (6% vs. 11%), hyponatremia (20% vs. 14%),
      primary tumor resection (61% vs. 47%), metastasectomy (21% vs. 9%), mean distance
      to cancer center (98.7+/-113.6 vs. 127.8+/-124.6 km), married/partnered (67% vs. 
      33%), and having children (64% vs. 36%). On multivariate logistic regression
      analysis, low performance status (odds ratio [OR], 5.1; 95% confidence interval
      [CI]: 3.1-8.1), not having children (OR, 3.3; 95% CI: 1.78-6.2), hyponatremia
      (OR, 2.9; 95% CI: 1.6-5.1), elevated alkaline phosphatase (OR, 2.9; 95% CI:
      1.8-4.8), and low albumin (OR, 2.2; 95% CI: 1.2-3.8) were correlated with low
      rates of chemotherapy use. CONCLUSIONS: Our results showed that the use of
      chemotherapy in patients with mCRC significantly varies between those with and
      without children.
FAU - Ahmed, Shahid
AU  - Ahmed S
AD  - Saskatchewan Cancer Agency, Division of Oncology.
FAU - Baig, Tayyba
AU  - Baig T
AD  - Saskatchewan Cancer Agency, Division of Oncology.
FAU - Iqbal, Nayyer
AU  - Iqbal N
AD  - Saskatchewan Cancer Agency, Division of Oncology.
FAU - Le, Duc
AU  - Le D
AD  - Saskatchewan Cancer Agency, Division of Oncology.
FAU - Chalchal, Haji
AU  - Chalchal H
AD  - Saskatchewan Cancer Agency, Division of Oncology.
FAU - Zaidi, Adnan
AU  - Zaidi A
AD  - Saskatchewan Cancer Agency, Division of Oncology.
FAU - Pahwa, Punam
AU  - Pahwa P
AD  - Department of Community Health and Epidemiology, University of Saskatchewan,
      Saskatoon, SK Canada.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Clin Oncol
JT  - American journal of clinical oncology
JID - 8207754
EDAT- 2019/02/23 06:00
MHDA- 2019/02/23 06:00
CRDT- 2019/02/22 06:00
PHST- 2019/02/23 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2019/02/22 06:00 [entrez]
AID - 10.1097/COC.0000000000000530 [doi]
PST - ppublish
SO  - Am J Clin Oncol. 2019 Apr;42(4):363-366. doi: 10.1097/COC.0000000000000530.