PMID- 30779134
OWN - NLM
STAT- MEDLINE
DCOM- 20190328
LR  - 20190328
IS  - 1096-9098 (Electronic)
IS  - 0022-4790 (Linking)
VI  - 119
IP  - 5
DP  - 2019 Apr
TI  - Mutation status and surgical selection.
PG  - 616-622
LID - 10.1002/jso.25413 [doi]
AB  - Current evidence cannot support denying metastasectomy in otherwise resectable
      patients solely based on their overall KRAS or BRAF mutational status. The
      combination of KRAS or BRAF mutational status with certain clinicopathologic
      characteristics has defined groups of patients who may not derive benefit from
      metastasectomy, but external validation is needed. The effect of certain KRAS or 
      BRAF variants on survival may be more pronounced and therefore future studies
      should consider them for surgical selection.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Margonis, Georgios A
AU  - Margonis GA
AD  - Department of Surgery, Johns Hopkins University, School of Medicine, Baltimore,
      Maryland.
FAU - Kreis, Martin E
AU  - Kreis ME
AD  - Department of General, Visceral and Vascular Surgery, Campus Benjamin Franklin,
      Charite Universitatsmedizin Berlin, Berlin, Germany.
FAU - Wolfgang, Christopher L
AU  - Wolfgang CL
AD  - Department of Surgery, Johns Hopkins University, School of Medicine, Baltimore,
      Maryland.
FAU - Weiss, Matthew J
AU  - Weiss MJ
AUID- ORCID: http://orcid.org/0000-0003-0553-248X
AD  - Department of Surgery, Johns Hopkins University, School of Medicine, Baltimore,
      Maryland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190219
PL  - United States
TA  - J Surg Oncol
JT  - Journal of surgical oncology
JID - 0222643
RN  - 0 (KRAS protein, human)
RN  - EC 2.7.11.1 (BRAF protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins B-raf)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
SB  - IM
MH  - Colorectal Neoplasms/*genetics/mortality/*surgery
MH  - Humans
MH  - Metastasectomy
MH  - Microsatellite Instability
MH  - *Mutation
MH  - Neoplasm Recurrence, Local
MH  - Proto-Oncogene Proteins B-raf/*genetics
MH  - Proto-Oncogene Proteins p21(ras)/*genetics
OTO - NOTNLM
OT  - BRAF
OT  - KRAS
OT  - metastasectomy
OT  - metastatic colorectal cancer
OT  - somatic mutations
EDAT- 2019/02/20 06:00
MHDA- 2019/03/29 06:00
CRDT- 2019/02/20 06:00
PHST- 2019/01/15 00:00 [received]
PHST- 2019/02/05 00:00 [accepted]
PHST- 2019/02/20 06:00 [pubmed]
PHST- 2019/03/29 06:00 [medline]
PHST- 2019/02/20 06:00 [entrez]
AID - 10.1002/jso.25413 [doi]
PST - ppublish
SO  - J Surg Oncol. 2019 Apr;119(5):616-622. doi: 10.1002/jso.25413. Epub 2019 Feb 19.