PMID- 30758835
OWN - NLM
STAT- In-Data-Review
LR  - 20190419
IS  - 1600-0412 (Electronic)
IS  - 0001-6349 (Linking)
VI  - 98
IP  - 5
DP  - 2019 May
TI  - Time from referral to ovarian tissue cryopreservation in a cohort of Danish
      women.
PG  - 616-624
LID - 10.1111/aogs.13575 [doi]
AB  - INTRODUCTION: Young women with a cancer diagnosis often have very little time to 
      decide whether or not to commence fertility-preserving strategies before
      initiating potentially sterilizing cancer treatment. Minimizing the interval from
      opting for fertility preservation to completion of the procedure will reduce the 
      potential risk of delaying cancer treatment. In the current study, we have
      evaluated the period of time from referral to ovarian tissue cryopreservation
      (OTC) to actual freezing of the tissue in a cohort of Danish women. MATERIAL AND 
      METHODS: The study population comprised 277 consecutive patients with both
      malignant and nonmalignant diseases referred for OTC from four centers in the
      Danish network. Statistical analysis was conducted to analyze the impact of age, 
      diagnosis, and referring center on the time from OTC-referral to OTC. A
      literature search for "random start" protocols for controlled ovarian stimulation
      (COS) for fertility preservation in cancer patients was performed. RESULTS: The
      time from OTC-referral to OTC was significantly influenced by diagnosis, age, and
      referring center. Women with malignant diseases other than breast cancer, such as
      sarcomas, pelvic cancers, and hematological cancers, experienced a significantly 
      shorter interval to OTC (5 days) than women with breast cancer (7 days) and
      nonmalignant diseases including systemic, ovarian, and hereditary conditions
      (13-17.5 days). Women over the age of 30 years experienced a significantly longer
      time to OTC (P < 0.03), and the diagnosis determined the length of the interval
      (P < 0.001). According to the literature, fertility preservation by oocyte
      vitrification requires 13-14 days, as the average time for 1 round of COS was 11 
      days and oocyte collection can be performed 2 days later. CONCLUSIONS: It is in
      the interest of both cancer patients and clinicians to perform fertility
      preservation as quickly and safely as possible. In a Danish setting, OTC provides
      a short interval of around 6 days from the patient choosing this option to
      completion of the procedure. This is considerably less time than what is needed
      to perform COS and oocyte vitrification, and therefore OTC might be considered
      the preferred choice of fertility preservation when urgency is needed.
CI  - (c) 2019 Nordic Federation of Societies of Obstetrics and Gynecology.
FAU - Kristensen, Stine Gry
AU  - Kristensen SG
AUID- ORCID: https://orcid.org/0000-0003-1194-8393
AD  - Laboratory of Reproductive Biology, The Juliane Marie Center for Women, Children 
      and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark.
FAU - Pors, Susanne Elisabeth
AU  - Pors SE
AD  - Laboratory of Reproductive Biology, The Juliane Marie Center for Women, Children 
      and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark.
FAU - Poulsen, Liv la Cour
AU  - Poulsen LC
AD  - The Fertility Clinic, Department of Gynecology and Obstetrics, Zealand University
      Hospital, Koge, Denmark.
FAU - Andersen, Signe Taasti
AU  - Andersen ST
AD  - Laboratory of Reproductive Biology, The Juliane Marie Center for Women, Children 
      and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark.
AD  - Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
FAU - Wakimoto, Yu
AU  - Wakimoto Y
AD  - Laboratory of Reproductive Biology, The Juliane Marie Center for Women, Children 
      and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark.
AD  - Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, 
      Hyogo, Japan.
FAU - Yding Andersen, Claus
AU  - Yding Andersen C
AD  - Laboratory of Reproductive Biology, The Juliane Marie Center for Women, Children 
      and Reproduction, University Hospital of Copenhagen, Copenhagen, Denmark.
AD  - Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.
LA  - eng
GR  - Dagmar Marshalls Foundation
GR  - Novo Nordic Foundation
GR  - Vera and Carl Johan Michaelsens Legat
GR  - Danish Cancer Foundation
GR  - Research Pools of Rigshospitalet
GR  - EU interregional project ReproUnion
PT  - Journal Article
DEP - 20190307
PL  - United States
TA  - Acta Obstet Gynecol Scand
JT  - Acta obstetricia et gynecologica Scandinavica
JID - 0370343
OTO - NOTNLM
OT  - cancer
OT  - fertility preservation
OT  - oocyte vitrification
OT  - ovarian tissue cryopreservation
OT  - random start ovarian stimulation
EDAT- 2019/02/14 06:00
MHDA- 2019/02/14 06:00
CRDT- 2019/02/14 06:00
PHST- 2018/11/22 00:00 [received]
PHST- 2019/02/08 00:00 [accepted]
PHST- 2019/02/14 06:00 [pubmed]
PHST- 2019/02/14 06:00 [medline]
PHST- 2019/02/14 06:00 [entrez]
AID - 10.1111/aogs.13575 [doi]
PST - ppublish
SO  - Acta Obstet Gynecol Scand. 2019 May;98(5):616-624. doi: 10.1111/aogs.13575. Epub 
      2019 Mar 7.