PMID- 30729372
OWN - NLM
STAT- Publisher
LR  - 20190207
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
DP  - 2019 Feb 7
TI  - Effect of biologic disease-modifying anti-rheumatic drugs for patients with
      rheumatoid arthritis who hope to become mothers.
LID - 10.1007/s10067-019-04450-3 [doi]
AB  - OBJECTIVES: We examined the effect of biologic disease-modifying anti-rheumatic
      drugs on the time to pregnancy in patients with rheumatoid arthritis who hope to 
      become mothers. Additionally, we evaluated adverse pregnancy outcomes and risk
      factors of these drugs. METHOD: We retrospectively investigated 25 pregnancies of
      19 patients who were taking disease-modifying anti-rheumatic drugs. In 15
      pregnancies, patients continued biologic disease-modifying anti-rheumatic drugs
      until conception (group A). In 10 pregnancies, patients discontinued biologic
      disease-modifying anti-rheumatic drugs and conventional synthetic
      disease-modifying anti-rheumatic drugs at the time of planning to conceive (group
      B). We used tumor necrosis factor inhibitors (certolizumab pegol and etanercept) 
      for group A patients. RESULTS: The mean time to pregnancy was shorter in group A 
      than in group B (5.9 +/- 3.8 vs 11.0 +/- 6.5 months, P = 0.04). The mean birth
      weight of newborns was lighter in group B than in group A (2446.5 +/- 352.4 vs
      2969.4 +/- 459.9 g, P = 0.007). There were no significant differences in the
      rates of preterm birth, light-for-date, and premature rupture of the membranes
      between the groups. In patients with preterm birth or light-for-date newborns,
      the mean dose of corticosteroids during pregnancy was significantly higher
      compared with that in those with full-term birth or non-light-for-date newborns
      (P = 0.02, P < 0.01, respectively). CONCLUSIONS: In patients with rheumatoid
      arthritis who hope to conceive, continuing biologic disease-modifying
      anti-rheumatic drugs at the time of conception could shorten the time to
      pregnancy. Using biologic disease-modifying anti-rheumatic drugs before pregnancy
      does not affect abortion, preterm birth, light-for-date, and premature rupture of
      the membranes.
FAU - Shimada, Hiromi
AU  - Shimada H
AUID- ORCID: http://orcid.org/0000-0001-5792-9919
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and
      Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe,
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan. h_kizu@med.kagawa-u.ac.jp.
FAU - Kameda, Tomohiro
AU  - Kameda T
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and
      Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe,
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Kanenishi, Kenji
AU  - Kanenishi K
AD  - Department of Perinatology and Gynecology, Faculty of Medicine, Kagawa
      University, Kagawa, Japan.
FAU - Miyatake, Nobuyuki
AU  - Miyatake N
AD  - Department of Hygiene, Faculty of Medicine, Kagawa University, Kagawa, Japan.
FAU - Nakashima, Shusaku
AU  - Nakashima S
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and
      Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe,
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Wakiya, Risa
AU  - Wakiya R
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and
      Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe,
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Kato, Mikiya
AU  - Kato M
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and
      Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe,
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Miyagi, Taichi
AU  - Miyagi T
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and
      Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe,
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Mansour, Mai Mahmoud Fahmy
AU  - Mansour MMF
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and
      Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe,
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Hata, Toshiyuki
AU  - Hata T
AD  - Department of Perinatology and Gynecology, Faculty of Medicine, Kagawa
      University, Kagawa, Japan.
FAU - Kadowaki, Norimitsu
AU  - Kadowaki N
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and
      Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe,
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Dobashi, Hiroaki
AU  - Dobashi H
AD  - Department of Internal Medicine, Division of Hematology, Rheumatology and
      Respiratory Medicine, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe,
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190207
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
OTO - NOTNLM
OT  - Biologic disease-modifying anti-rheumatic drugs
OT  - Conception
OT  - Light-for-date
OT  - Preterm birth
OT  - Rheumatoid arthritis
OT  - Time to pregnancy
EDAT- 2019/02/08 06:00
MHDA- 2019/02/08 06:00
CRDT- 2019/02/08 06:00
PHST- 2018/10/09 00:00 [received]
PHST- 2019/01/22 00:00 [accepted]
PHST- 2019/01/20 00:00 [revised]
PHST- 2019/02/08 06:00 [entrez]
PHST- 2019/02/08 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
AID - 10.1007/s10067-019-04450-3 [doi]
AID - 10.1007/s10067-019-04450-3 [pii]
PST - aheadofprint
SO  - Clin Rheumatol. 2019 Feb 7. pii: 10.1007/s10067-019-04450-3. doi:
      10.1007/s10067-019-04450-3.