PMID- 30729371
OWN - NLM
STAT- Publisher
LR  - 20190207
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
DP  - 2019 Feb 7
TI  - Exploring metabolic and inflammatory abnormalities in rheumatoid arthritis
      patients developing stroke disease: a case-control study using electronic medical
      record data in northern China.
LID - 10.1007/s10067-019-04440-5 [doi]
AB  - OBJECTIVES: Intend to investigate the roles of serum lipids, inflammatory
      markers, and serological status in rheumatoid arthritis and stroke patients by
      using case-control study. MATERIALS AND METHODS: Clinical data were retrieved
      from the electronic medical record of the First Affiliated Hospital of China
      Medical University during January 2011 to March 2018. The obtained data were
      categorized into case groups and three control groups, in the ratios of 1:2,
      respectively, with all matching age and gender. Multinomial logistic regression
      analysis and restricted cubic spline were conducted examining the associations
      between serum lipids, inflammatory markers, serological status, and the risk of
      stroke among RA patients. RESULTS: The present studies included 1057 study
      subjects. The elevated ESR, LDL-C levels, and much higher CRP levels >/= 230 mg/L
      were independent risk factors for RA patients in developing stroke. Furthermore, 
      we found that ESR and LDL-C levels could exhibit a linear association with the
      risk of comorbid stroke while CRP level had a nonlinearity association with
      stroke risk among RA patients. CONCLUSIONS: A close monitoring is required for RA
      patients with dyslipidemia and elevated inflammatory markers, and the primary
      stroke preventive strategies should be directed against these risk factors.
FAU - Xin, Fangran
AU  - Xin F
AD  - Department of Clinical Epidemiology and Evidence-based medicine, The First
      Affiliated Hospital of China Medical University, No.155, Nan Jing Bei Street,
      Shenyang, 110001, Liaoning Province, China.
FAU - Fu, Lingyu
AU  - Fu L
AD  - Department of Clinical Epidemiology and Evidence-based medicine, The First
      Affiliated Hospital of China Medical University, No.155, Nan Jing Bei Street,
      Shenyang, 110001, Liaoning Province, China. fulingyucmu@sina.com.
AD  - Department of Medical Record Management Center, The First Affiliated Hospital,
      China Medical University, Shenyang, China. fulingyucmu@sina.com.
FAU - Liu, Haina
AU  - Liu H
AD  - Department of Rheumatology, The First Affiliated Hospital, China Medical
      University, Shenyang, China.
FAU - Xu, Yunwei
AU  - Xu Y
AD  - Department of Medical Record Management Center, The First Affiliated Hospital,
      China Medical University, Shenyang, China.
FAU - Wei, Tingting
AU  - Wei T
AD  - Department of Clinical Epidemiology and Evidence-based medicine, The First
      Affiliated Hospital of China Medical University, No.155, Nan Jing Bei Street,
      Shenyang, 110001, Liaoning Province, China.
FAU - Chen, Meng
AU  - Chen M
AD  - Department of Clinical Epidemiology and Evidence-based medicine, The First
      Affiliated Hospital of China Medical University, No.155, Nan Jing Bei Street,
      Shenyang, 110001, Liaoning Province, China.
LA  - eng
GR  - ChiCTR1800017343/The prognosis risk model for rheumatoid arthritis based on
      integrated clinical and genetic data by using bayesian
PT  - Journal Article
DEP - 20190207
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
OTO - NOTNLM
OT  - Dyslipidemia
OT  - Inflammatory marker
OT  - Rheumatoid arthritis
OT  - Serum lipids
OT  - Stroke
EDAT- 2019/02/08 06:00
MHDA- 2019/02/08 06:00
CRDT- 2019/02/08 06:00
PHST- 2018/09/24 00:00 [received]
PHST- 2019/01/14 00:00 [accepted]
PHST- 2018/12/24 00:00 [revised]
PHST- 2019/02/08 06:00 [entrez]
PHST- 2019/02/08 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
AID - 10.1007/s10067-019-04440-5 [doi]
AID - 10.1007/s10067-019-04440-5 [pii]
PST - aheadofprint
SO  - Clin Rheumatol. 2019 Feb 7. pii: 10.1007/s10067-019-04440-5. doi:
      10.1007/s10067-019-04440-5.