PMID- 30709948
OWN - NLM
STAT- Publisher
LR  - 20190202
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
DP  - 2019 Feb 1
TI  - Repair of Erosions in Patients with Rheumatoid Arthritis.
LID - jrheum.180557 [pii]
LID - 10.3899/jrheum.180557 [doi]
AB  - OBJECTIVE: The aim of this study was to examine the occurrence of repair in a
      cohort of conventionally treated patients with early rheumatoid arthritis over 8 
      years. METHODS: There were 395 patients included in the BARFOT study having
      radiographs of hands and feet at inclusion, and at 1, 2, 5, and 8 years, which
      were chronologically scored for erosions by the Sharp/van der Heijde method. An
      erosion with repair was defined as an erosion that has become partially or
      totally filled, with or without sclerosis. RESULTS: Erosions with repair were
      observed in 64 patients (16%) at 1 year, 113 (29%) at 2 years, 142 (36%) at 5
      years, and 200 (51%) at 8 years. At the 1-year visit, 13% of the patients with at
      least 1 new erosion showed repair versus 3% of the patients with no new erosions 
      (p = 0.001). At 2, 5, and 8 years the corresponding figures were 22% and 6%, 28% 
      and 8%, and 39% and 11%, respectively (all p = 0.001). The sum of all repaired
      erosions correlated strongly with the sum of all erosions and with the sum of all
      erosion scores (r = 0.79 and 0.77). Presence of rheumatoid factor (RF) and
      anticyclic citrullinated peptide antibodies (anti-CCP) was significantly
      associated with both new erosions and repair. CONCLUSION: Repair was more common 
      than previously described. The frequency of repair increased over time and was
      associated with the number of erosions. RF- and anti-CCP-positivity, patient age,
      and presence of erosions at baseline were independent predictors of repair.
FAU - Forslind, Kristina
AU  - Forslind K
AUID- ORCID: http://orcid.org/0000-0003-1692-9597
AD  - From Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, 
      Rheumatology, Lund; Department of Research and Education, Skanevard Sund, Region 
      Skane, Helsingborg s Hospital, Helsingborg, Sweden. This study was supported by
      grants from the Swedish Rheumatism Association, and the Foundation for Assistance
      to Disabled People in Skane (Stiftelsen for Bistand at Rorelsehindrade i Skane). 
      K. Forslind, Associate Professor, Lund University, Faculty of Medicine,
      Department of Clinical Sciences Lund, Rheumatology, and the Department of
      Research and Education, Skanevard Sund, Region Skane, Helsingborg's Hospital; K. 
      Eberhardt, Associate Professor, Lund University, Faculty of Medicine, Department 
      of Clinical Sciences Lund, Rheumatology; B. Svensson, Associate Professor, Lund
      University, Faculty of Medicine, Department of Clinical Sciences Lund,
      Rheumatology. Address correspondence to K. Forslind, Department of Research and
      Education, Skanevard Sund, Region Skane, Helsingborg's Hospital, 25187
      Helsingborg, Sweden. E-mail: kforslind@hotmail.com, Kristina.Forslind@med.lu.se. 
      Accepted for publication October 16, 2018.
FAU - Eberhardt, Kerstin
AU  - Eberhardt K
AD  - From Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, 
      Rheumatology, Lund; Department of Research and Education, Skanevard Sund, Region 
      Skane, Helsingborg s Hospital, Helsingborg, Sweden. This study was supported by
      grants from the Swedish Rheumatism Association, and the Foundation for Assistance
      to Disabled People in Skane (Stiftelsen for Bistand at Rorelsehindrade i Skane). 
      K. Forslind, Associate Professor, Lund University, Faculty of Medicine,
      Department of Clinical Sciences Lund, Rheumatology, and the Department of
      Research and Education, Skanevard Sund, Region Skane, Helsingborg's Hospital; K. 
      Eberhardt, Associate Professor, Lund University, Faculty of Medicine, Department 
      of Clinical Sciences Lund, Rheumatology; B. Svensson, Associate Professor, Lund
      University, Faculty of Medicine, Department of Clinical Sciences Lund,
      Rheumatology. Address correspondence to K. Forslind, Department of Research and
      Education, Skanevard Sund, Region Skane, Helsingborg's Hospital, 25187
      Helsingborg, Sweden. E-mail: kforslind@hotmail.com, Kristina.Forslind@med.lu.se. 
      Accepted for publication October 16, 2018.
FAU - Svensson, Bjorn
AU  - Svensson B
AUID- ORCID: https://orcid.org/0000-0002-0687-5030
AD  - From Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, 
      Rheumatology, Lund; Department of Research and Education, Skanevard Sund, Region 
      Skane, Helsingborg s Hospital, Helsingborg, Sweden. This study was supported by
      grants from the Swedish Rheumatism Association, and the Foundation for Assistance
      to Disabled People in Skane (Stiftelsen for Bistand at Rorelsehindrade i Skane). 
      K. Forslind, Associate Professor, Lund University, Faculty of Medicine,
      Department of Clinical Sciences Lund, Rheumatology, and the Department of
      Research and Education, Skanevard Sund, Region Skane, Helsingborg's Hospital; K. 
      Eberhardt, Associate Professor, Lund University, Faculty of Medicine, Department 
      of Clinical Sciences Lund, Rheumatology; B. Svensson, Associate Professor, Lund
      University, Faculty of Medicine, Department of Clinical Sciences Lund,
      Rheumatology. Address correspondence to K. Forslind, Department of Research and
      Education, Skanevard Sund, Region Skane, Helsingborg's Hospital, 25187
      Helsingborg, Sweden. E-mail: kforslind@hotmail.com, Kristina.Forslind@med.lu.se. 
      Accepted for publication October 16, 2018.
LA  - eng
PT  - Journal Article
DEP - 20190201
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
EDAT- 2019/02/03 06:00
MHDA- 2019/02/03 06:00
CRDT- 2019/02/03 06:00
PHST- 2019/02/03 06:00 [entrez]
PHST- 2019/02/03 06:00 [pubmed]
PHST- 2019/02/03 06:00 [medline]
AID - jrheum.180557 [pii]
AID - 10.3899/jrheum.180557 [doi]
PST - aheadofprint
SO  - J Rheumatol. 2019 Feb 1. pii: jrheum.180557. doi: 10.3899/jrheum.180557.