PMID- 30698838
OWN - NLM
STAT- Publisher
LR  - 20190203
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
DP  - 2019 Jan 30
TI  - Neuroprotective factors and incident hearing impairment in the epidemiology of
      hearing loss study.
LID - 10.1002/lary.27847 [doi]
AB  - OBJECTIVE: Hearing impairment (HI) is common in aging adults. Aldosterone,
      insulin-like growth factor (IGF1), and brain-derived neurotrophic factor (BDNF)
      have been identified as potentially protective of hearing. The present study aims
      to investigate these relationships. METHODS: The Epidemiology of Hearing Loss
      Study is a longitudinal population-based study of aging in Beaver Dam, Wisconsin,
      that began in 1993. Baseline for the present investigation is the 1998 to 2000
      phase. Follow-up exams occurred approximately every 5 years, with the most recent
      occurring from 2013 to 2016. Hearing was measured by pure-tone audiometry. HI was
      defined as a pure tone average (PTA) > 25 decibels hearing level in either ear.
      Change in PTA was the difference between follow-up examinations and baseline.
      Baseline serum samples were used to measure biomarkers in 2017. Hazard ratios
      (HRs) and 95% confidence intervals (CIs) were estimated to assess the effect of
      biomarker levels in the lowest quintile (Q1) versus the highest (Q5) on incident 
      HI and PTA change. RESULTS: There were 1,088 participants (69.3% women) at risk
      of HI included in analyses. The mean baseline age was 63.8 years (standard
      deviation = 7.0). The 16-year incidence of HI was 54.9% and was higher in men
      (61.1%) than women (52.1%). In age- and sex-adjusted models, aldosterone (HR =
      1.06, 95% CI = 0.82-1.37), IGF1 (HR = 0.92, 95% CI = 0.71-1.19), and BDNF (HR =
      0.86, 95% CI = 0.66-1.12) levels were not associated with risk of HI. PTA change 
      was similarly not affected by biomarker levels. CONCLUSION: Aldosterone, IGF1,
      and BDNF were not associated with decreased risk of age-related hearing loss in
      this study. LEVEL OF EVIDENCE: 2b. Laryngoscope, 2019.
CI  - (c) 2019 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Paulsen, Adam J
AU  - Paulsen AJ
AUID- ORCID: https://orcid.org/0000-0001-9919-0577
AD  - Department of Ophthalmology and Visual Sciences, School of Medicine and Public
      Health, University of Wisconsin-Madison, Madison, Wisconsin.
FAU - Cruickshanks, Karen J
AU  - Cruickshanks KJ
AD  - Department of Ophthalmology and Visual Sciences, School of Medicine and Public
      Health, University of Wisconsin-Madison, Madison, Wisconsin.
AD  - Department of Population Health Sciences, School of Medicine and Public Health,
      University of Wisconsin-Madison, Madison, Wisconsin.
FAU - Pinto, Alex
AU  - Pinto A
AD  - Department of Ophthalmology and Visual Sciences, School of Medicine and Public
      Health, University of Wisconsin-Madison, Madison, Wisconsin.
FAU - Schubert, Carla R
AU  - Schubert CR
AD  - Department of Ophthalmology and Visual Sciences, School of Medicine and Public
      Health, University of Wisconsin-Madison, Madison, Wisconsin.
FAU - Dalton, Dayna S
AU  - Dalton DS
AD  - Department of Ophthalmology and Visual Sciences, School of Medicine and Public
      Health, University of Wisconsin-Madison, Madison, Wisconsin.
FAU - Fischer, Mary E
AU  - Fischer ME
AD  - Department of Ophthalmology and Visual Sciences, School of Medicine and Public
      Health, University of Wisconsin-Madison, Madison, Wisconsin.
FAU - Klein, Barbara E K
AU  - Klein BEK
AD  - Department of Ophthalmology and Visual Sciences, School of Medicine and Public
      Health, University of Wisconsin-Madison, Madison, Wisconsin.
FAU - Klein, Ronald
AU  - Klein R
AD  - Department of Ophthalmology and Visual Sciences, School of Medicine and Public
      Health, University of Wisconsin-Madison, Madison, Wisconsin.
FAU - Tsai, Michael Y
AU  - Tsai MY
AD  - Department of Laboratory Medicine and Pathology, University of Minnesota Medical 
      School-Minneapolis, Minneapolis, Minnesota, U.S.A.
FAU - Tweed, Ted S
AU  - Tweed TS
AD  - Department of Ophthalmology and Visual Sciences, School of Medicine and Public
      Health, University of Wisconsin-Madison, Madison, Wisconsin.
LA  - eng
GR  - U10 EY006594/EY/NEI NIH HHS/United States
GR  - R37 AG011099/AG/NIA NIH HHS/United States
GR  - Research to Prevent Blindness
GR  - U10EY06594/National Eye Institute
GR  - R37AG011099/National Institute on Aging
PT  - Journal Article
DEP - 20190130
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
OTO - NOTNLM
OT  - Epidemiology
OT  - aldosterone
OT  - audiology
OT  - brain-derived neurotrophic factor
OT  - insulin-like growth factor
OT  - neuroprotective
OT  - risk factors
OT  - sensorineural hearing loss
EDAT- 2019/01/31 06:00
MHDA- 2019/01/31 06:00
CRDT- 2019/01/31 06:00
PHST- 2019/01/08 00:00 [accepted]
PHST- 2019/01/31 06:00 [entrez]
PHST- 2019/01/31 06:00 [pubmed]
PHST- 2019/01/31 06:00 [medline]
AID - 10.1002/lary.27847 [doi]
PST - aheadofprint
SO  - Laryngoscope. 2019 Jan 30. doi: 10.1002/lary.27847.