PMID- 30685246
OWN - NLM
STAT- In-Data-Review
LR  - 20190204
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 37
IP  - 8
DP  - 2019 Feb 14
TI  - Health care worker vaccination against Ebola: Vaccine acceptance and employment
      duration in Sierra Leone.
PG  - 1101-1108
LID - S0264-410X(19)30029-5 [pii]
LID - 10.1016/j.vaccine.2018.12.060 [doi]
AB  - Health care workers (HCW) are at high risk of Ebola virus disease (EVD) infection
      during epidemics and may contribute to onward transmission, and therefore
      HCW-targeted prophylactic vaccination strategies are being considered as
      interventions. To assess the feasibility of preventive HCW vaccination, we
      conducted a pilot survey on staff turnover and vaccine acceptance amongst 305 HCW
      in Freetown and Kambia districts of Sierra Leone. Multivariable logistic
      regression demonstrated which demographic and behavioural factors were associated
      with acceptance of a hypothetical new vaccine. We quantified the duration of
      employment of HCW, and used multivariable gamma regression to detect associations
      with duration of employment in current or any health care position. Finally, we
      simulated populations of HCW, to determine the likely future immunisation
      coverage amongst HCW based on our estimates of vaccine acceptance and employment 
      duration. Most HCW we surveyed had a positive opinion of EVD vaccination (76.3%).
      We found that being a volunteer HCW (vs being on the government payroll) was
      associated with increased vaccine acceptance. We found that HCW have stable
      employment, with a mean duration of employment in the health sector of 10.9years 
      (median 8.0years). Older age and being on the government payroll (vs volunteer
      HCW) were associated with a longer duration of employment in the health sector.
      Assuming a single vaccine campaign, with 76.3% vaccine acceptance, 100% vaccine
      efficacy and no waning of vaccine-induced protection, immunisation coverage was
      sustained over 50% until 6years after a vaccination campaign. If vaccine-induced 
      immunity wanes at 10% per year, then the immunisation coverage among HCW would
      fall below 50% after 3years. Vaccinating HCW against EVD could be feasible as
      employment appeared stable and vaccine acceptance high. However, even with high
      vaccine efficacy and long-lasting immunity, repeated campaigns or vaccination at 
      employment start may be necessary to maintain high coverage.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Jendrossek, Mario
AU  - Jendrossek M
AD  - Department of Infectious Disease Epidemiology, London School of Hygiene &
      Tropical Medicine, Keppel Street, London WC1E 7HT, UK; Centre for Mathematical
      Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine,
      Keppel Street, London WC1E 7HT, UK.
FAU - Edmunds, W John
AU  - Edmunds WJ
AD  - Department of Infectious Disease Epidemiology, London School of Hygiene &
      Tropical Medicine, Keppel Street, London WC1E 7HT, UK; Centre for Mathematical
      Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine,
      Keppel Street, London WC1E 7HT, UK.
FAU - Rohan, Hana
AU  - Rohan H
AD  - UK Public Health Rapid Support Team, London School of Hygiene & Tropical Medicine
      and Public Health England, UK.
FAU - Clifford, Samuel
AU  - Clifford S
AD  - Department of Infectious Disease Epidemiology, London School of Hygiene &
      Tropical Medicine, Keppel Street, London WC1E 7HT, UK; Centre for Mathematical
      Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine,
      Keppel Street, London WC1E 7HT, UK.
FAU - Mooney, Thomas A
AU  - Mooney TA
AD  - Department of Clinical Research, London School of Hygiene & Tropical Medicine,
      Keppel Street, London WC1E 7HT, UK.
FAU - Eggo, Rosalind M
AU  - Eggo RM
AD  - Department of Infectious Disease Epidemiology, London School of Hygiene &
      Tropical Medicine, Keppel Street, London WC1E 7HT, UK; Centre for Mathematical
      Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine,
      Keppel Street, London WC1E 7HT, UK. Electronic address: r.eggo@lshtm.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20190123
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
OTO - NOTNLM
OT  - Ebola virus disease
OT  - Health care workers
OT  - Mathematical modelling
OT  - Public health
OT  - Vaccination
OT  - Vaccine sentiment
EDAT- 2019/01/28 06:00
MHDA- 2019/01/28 06:00
CRDT- 2019/01/28 06:00
PHST- 2018/09/16 00:00 [received]
PHST- 2018/11/19 00:00 [revised]
PHST- 2018/12/21 00:00 [accepted]
PHST- 2019/01/28 06:00 [pubmed]
PHST- 2019/01/28 06:00 [medline]
PHST- 2019/01/28 06:00 [entrez]
AID - S0264-410X(19)30029-5 [pii]
AID - 10.1016/j.vaccine.2018.12.060 [doi]
PST - ppublish
SO  - Vaccine. 2019 Feb 14;37(8):1101-1108. doi: 10.1016/j.vaccine.2018.12.060. Epub
      2019 Jan 23.