PMID- 30682364
OWN - NLM
STAT- In-Data-Review
LR  - 20190405
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 220
IP  - 4
DP  - 2019 Apr
TI  - Inherited predisposition to stillbirth: an intergenerational analysis of 26,788
      mother-daughter pairs.
PG  - 393.e1-393.e7
LID - S0002-9378(19)30245-5 [pii]
LID - 10.1016/j.ajog.2019.01.215 [doi]
AB  - BACKGROUND: Previous evidence suggests that placental dysfunction, which includes
      preeclampsia, is inherited from mother to daughter, but heritability of
      stillbirth has never been investigated. OBJECTIVE: The purpose of this study was 
      to investigate whether there is an inherited predisposition to stillbirth that is
      transmitted from mother to daughter. STUDY DESIGN: We carried out a nested
      case-control study within the intergenerational cohort held in the Aberdeen
      Maternity and Neonatal Databank. All mothers who had at least 1 daughter in
      Aberdeen, United Kingdom, between 1949 and 2000 were included. Mother-daughter
      pairs were linked with the use of the Scottish Community Health Index number. The
      main exposure was the mother's history of stillbirth. The primary outcome was
      stillbirth in any of the daughter's pregnancies. A population average model that 
      used generalized estimating equations with robust standard errors was used to
      estimate odds of a mother's history of stillbirth in daughters with a stillbirth 
      compared with daughters with only livebirths. This method accounted for
      clustering of daughters within mothers, and multi-adjusted analyses were
      performed to include confounders at the daughter's pregnancy level. RESULTS:
      Among the daughters, 384 had a history of >/=1 stillbirths (cases); 26,404 only
      ever had livebirths (control subjects). We found no statistically significant
      association between mothers' history of stillbirth (adjusted odds ratio, 0.63;
      95% confidence interval, 0.24-1.63) or miscarriage (adjusted odds ratio, 1.01;
      95% confidence interval, 0.71-1.42) and stillbirth in daughters. CONCLUSION: This
      is the first study to investigate an inherited predisposition to stillbirth.
      There was no evidence of an inherited predisposition to stillbirth transmitted
      from mother to daughter.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Woolner, Andrea M F
AU  - Woolner AMF
AD  - Aberdeen Centre for Women's Health Research, Institute of Applied Health
      Sciences; School of Medicine, Medical Sciences and Nutrition, University of
      Aberdeen, United Kingdom. Electronic address: a.woolner@abdn.ac.uk.
FAU - Raja, Edwin Amalraj
AU  - Raja EA
AD  - Medical Statistics Team, Institute of Applied Health Sciences; School of
      Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom.
FAU - Bhattacharya, Siladitya
AU  - Bhattacharya S
AD  - Cardiff University School of Medicine, College of Biomedical and Life Sciences,
      Cardiff, United Kingdom.
FAU - Danielian, Peter
AU  - Danielian P
AD  - Department of Obstetrics & Gynaecology, Aberdeen Maternity Hospital (NHS
      Grampian), Aberdeen, United Kingdom.
FAU - Bhattacharya, Sohinee
AU  - Bhattacharya S
AD  - Aberdeen Centre for Women's Health Research, Institute of Applied Health
      Sciences; School of Medicine, Medical Sciences and Nutrition, University of
      Aberdeen, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20190123
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
OTO - NOTNLM
OT  - familial
OT  - intergenerational
OT  - intrauterine
OT  - mother-daughter pairs
OT  - stillbirth
EDAT- 2019/01/27 06:00
MHDA- 2019/01/27 06:00
CRDT- 2019/01/26 06:00
PHST- 2018/08/30 00:00 [received]
PHST- 2018/12/27 00:00 [revised]
PHST- 2019/01/16 00:00 [accepted]
PHST- 2019/01/27 06:00 [pubmed]
PHST- 2019/01/27 06:00 [medline]
PHST- 2019/01/26 06:00 [entrez]
AID - S0002-9378(19)30245-5 [pii]
AID - 10.1016/j.ajog.2019.01.215 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2019 Apr;220(4):393.e1-393.e7. doi:
      10.1016/j.ajog.2019.01.215. Epub 2019 Jan 23.