PMID- 30659352
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 276
IP  - 4
DP  - 2019 Apr
TI  - Perimarginal lymph nodes: an undervalued entity in oral cancer.
PG  - 1147-1151
LID - 10.1007/s00405-019-05291-1 [doi]
AB  - PURPOSE: In a previous study, we gave a surgical description of a group of lymph 
      nodes in the submandibular area at risk of remaining undissected during neck
      dissection (ND) for which we have proposed the term "perimarginal nodes" (PMNs)
      due to their proximity to marginal mandibular nerve (MMN). The aim of this study 
      is to evaluate prevalence of PMNs involvement in oral cavity squamous cell cancer
      (OCSCC) and to verify if metastases are related to primary tumor characteristics 
      or to the state of the neck. METHODS: We recruited a total of 39 consecutive
      patients diagnosed with OCSCC candidate to ND. Histological characteristics of
      PMNs were analyzed and the incidence of metastases in relation to the primary
      tumor characteristics were noted. RESULTS: PMNs were found to be involved with
      metastases in 8 patients (20.5%). No characteristic of the primary tumor seems to
      influence the metastatic involvement of the PMNs. CONCLUSIONS: PMNs represent a
      frequent site of micro-metastases in patients diagnosed with OCSCC regardless of 
      other characteristics of the primary tumor.
FAU - Tirelli, Giancarlo
AU  - Tirelli G
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Azienda Sanitaria
      Universitaria Integrata di Trieste-ASUITS, Strada di Fiume 447, 39149, Trieste,
      Italy.
FAU - Gatto, Annalisa
AU  - Gatto A
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Azienda Sanitaria
      Universitaria Integrata di Trieste-ASUITS, Strada di Fiume 447, 39149, Trieste,
      Italy.
FAU - Marcuzzo, Alberto Vito
AU  - Marcuzzo AV
AUID- ORCID: http://orcid.org/0000-0002-1340-9900
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Azienda Sanitaria
      Universitaria Integrata di Trieste-ASUITS, Strada di Fiume 447, 39149, Trieste,
      Italy. avmarcuzzo@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190118
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Carcinoma, Squamous Cell/pathology/surgery
MH  - Diagnostic Errors/prevention & control
MH  - Female
MH  - Humans
MH  - Incidence
MH  - *Lymph Nodes/diagnostic imaging/pathology/surgery
MH  - *Lymphatic Metastasis/pathology/prevention & control
MH  - Male
MH  - Middle Aged
MH  - *Mouth Neoplasms/pathology/surgery
MH  - Neck
MH  - *Neck Dissection/adverse effects/methods
MH  - Prognosis
MH  - *Squamous Cell Carcinoma of Head and Neck/pathology/surgery
OTO - NOTNLM
OT  - Neck dissection
OT  - Oral cavity cancer
OT  - Perifacial nodes
OT  - Perimarginal nodes
OT  - Submandibular nodes
EDAT- 2019/01/20 06:00
MHDA- 2019/05/21 06:00
CRDT- 2019/01/20 06:00
PHST- 2018/11/20 00:00 [received]
PHST- 2019/01/11 00:00 [accepted]
PHST- 2019/01/20 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2019/01/20 06:00 [entrez]
AID - 10.1007/s00405-019-05291-1 [doi]
AID - 10.1007/s00405-019-05291-1 [pii]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2019 Apr;276(4):1147-1151. doi:
      10.1007/s00405-019-05291-1. Epub 2019 Jan 18.