PMID- 30650326
OWN - NLM
STAT- MEDLINE
DCOM- 20190130
LR  - 20190726
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 380
IP  - 3
DP  - 2019 Jan 17
TI  - Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria.
PG  - 229-241
LID - 10.1056/NEJMoa1802537 [doi]
AB  - BACKGROUND: Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has 
      been associated with relapse prevention through the clearance of P. vivax
      parasitemia and hypnozoites, termed "radical cure." METHODS: We performed a phase
      3, prospective, double-blind, double-dummy, randomized, controlled trial to
      compare tafenoquine with primaquine in terms of safety and efficacy. The trial
      was conducted at seven hospitals or clinics in Peru, Brazil, Colombia, Vietnam,
      and Thailand and involved patients with normal glucose-6-phosphate dehydrogenase 
      (G6PD) enzyme activity and female patients with moderate G6PD enzyme deficiency; 
      all patients had confirmed P. vivax parasitemia. The patients were randomly
      assigned, in a 2:1 ratio, to receive a single 300-mg dose of tafenoquine or 15 mg
      of primaquine once daily for 14 days (administered under supervision); all
      patients received a 3-day course of chloroquine and were followed for 180 days.
      The primary safety outcome was a protocol-defined decrease in the hemoglobin
      level (>3.0 g per deciliter or >/=30% from baseline or to a level of <6.0 g per
      deciliter). Freedom from recurrence of P. vivax parasitemia at 6 months was the
      primary efficacy outcome in a planned patient-level meta-analysis of the current 
      trial and another phase 3 trial of tafenoquine and primaquine (per-protocol
      populations), and an odds ratio for recurrence of 1.45 (tafenoquine vs.
      primaquine) was used as a noninferiority margin. RESULTS: A protocol-defined
      decrease in the hemoglobin level occurred in 4 of 166 patients (2.4%; 95%
      confidence interval [CI], 0.9 to 6.0) in the tafenoquine group and in 1 of 85
      patients (1.2%; 95% CI, 0.2 to 6.4) in the primaquine group, for a between-group 
      difference of 1.2 percentage points (95% CI, -4.2 to 5.0). In the patient-level
      meta-analysis, the percentage of patients who were free from recurrence at 6
      months was 67.0% (95% CI, 61.0 to 72.3) among the 426 patients in the tafenoquine
      group and 72.8% (95% CI, 65.6 to 78.8) among the 214 patients in the primaquine
      group. The efficacy of tafenoquine was not shown to be noninferior to that of
      primaquine (odds ratio for recurrence, 1.81; 95% CI, 0.82 to 3.96). CONCLUSIONS: 
      Among patients with normal G6PD enzyme activity, the decline in hemoglobin level 
      with tafenoquine did not differ significantly from that with primaquine.
      Tafenoquine showed efficacy for the radical cure of P. vivax malaria, although
      tafenoquine was not shown to be noninferior to primaquine. (Funded by
      GlaxoSmithKline and Medicines for Malaria Venture; GATHER ClinicalTrials.gov
      number, NCT02216123 .).
FAU - Llanos-Cuentas, Alejandro
AU  - Llanos-Cuentas A
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Lacerda, Marcus V G
AU  - Lacerda MVG
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Hien, Tran T
AU  - Hien TT
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Velez, Ivan D
AU  - Velez ID
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Namaik-Larp, Chayadol
AU  - Namaik-Larp C
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Chu, Cindy S
AU  - Chu CS
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Villegas, Maria F
AU  - Villegas MF
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Val, Fernando
AU  - Val F
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Monteiro, Wuelton M
AU  - Monteiro WM
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Brito, Marcelo A M
AU  - Brito MAM
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Costa, Monica R F
AU  - Costa MRF
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Chuquiyauri, Raul
AU  - Chuquiyauri R
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Casapia, Martin
AU  - Casapia M
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Nguyen, Chau H
AU  - Nguyen CH
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Aruachan, Sandra
AU  - Aruachan S
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Papwijitsil, Ratchadaporn
AU  - Papwijitsil R
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Nosten, Francois H
AU  - Nosten FH
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Bancone, Germana
AU  - Bancone G
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Angus, Brian
AU  - Angus B
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Duparc, Stephan
AU  - Duparc S
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Craig, Graham
AU  - Craig G
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Rousell, Victoria M
AU  - Rousell VM
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Jones, Sion W
AU  - Jones SW
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Hardaker, Elizabeth
AU  - Hardaker E
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Clover, Donna D
AU  - Clover DD
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Kendall, Lindsay
AU  - Kendall L
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Mohamed, Khadeeja
AU  - Mohamed K
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Koh, Gavin C K W
AU  - Koh GCKW
AUID- ORCID: 0000-0002-7336-1566
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Wilches, Viviana M
AU  - Wilches VM
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Breton, John J
AU  - Breton JJ
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
FAU - Green, Justin A
AU  - Green JA
AD  - From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.);
      Fundacao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V.,
      W.M.M., M.A.M.B., M.R.F.C.), and Fundacao Oswaldo Cruz, Manguinhos, Rio de
      Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho
      Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin
      (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and
      IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak
      (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical
      Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot
      (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and
      Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical 
      Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford,
      GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M.,
      G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United
      Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline,
      Collegeville, PA (V.M.W., J.J.B.).
LA  - eng
SI  - ClinicalTrials.gov/NCT02216123
PT  - Clinical Trial, Phase III
PT  - Comparative Study
PT  - Equivalence Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (Aminoquinolines)
RN  - 0 (Antimalarials)
RN  - 0 (Hemoglobins)
RN  - 262P8GS9L9 (tafenoquine)
RN  - 886U3H6UFF (Chloroquine)
RN  - EC 1.1.1.49 (G6PD protein, human)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - MVR3634GX1 (Primaquine)
SB  - AIM
SB  - IM
CIN - N Engl J Med. 2019 Jan 17;380(3):285-286. PMID: 30650321
CIN - N Engl J Med. 2019 May 9;380(19):1875. PMID: 31067383
CIN - N Engl J Med. 2019 May 9;380(19):1875-1876. PMID: 31067384
MH  - Adolescent
MH  - Adult
MH  - Aminoquinolines/*administration & dosage/adverse effects
MH  - Antimalarials/*administration & dosage/adverse effects
MH  - Chloroquine/therapeutic use
MH  - Disease-Free Survival
MH  - Double-Blind Method
MH  - Drug Therapy, Combination
MH  - Female
MH  - Glucosephosphate Dehydrogenase/metabolism
MH  - Glucosephosphate Dehydrogenase Deficiency/complications
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Malaria, Vivax/complications/*drug therapy
MH  - Male
MH  - Parasitemia/drug therapy
MH  - *Plasmodium vivax/isolation & purification
MH  - Primaquine/*administration & dosage/adverse effects
MH  - Prospective Studies
MH  - Secondary Prevention/*methods
PMC - PMC6657225
EDAT- 2019/01/17 06:00
MHDA- 2019/01/31 06:00
CRDT- 2019/01/17 06:00
PHST- 2019/01/17 06:00 [entrez]
PHST- 2019/01/17 06:00 [pubmed]
PHST- 2019/01/31 06:00 [medline]
AID - 10.1056/NEJMoa1802537 [doi]
PST - ppublish
SO  - N Engl J Med. 2019 Jan 17;380(3):229-241. doi: 10.1056/NEJMoa1802537.