PMID- 30649505
OWN - NLM
STAT- Publisher
LR  - 20190116
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
DP  - 2019 Jan 11
TI  - Poliovirus type 2 seroprevalence following full or fractional-dose of inactivated
      poliovirus vaccine in the period after Sabin type 2 withdrawal in Sri Lanka.
LID - 10.1093/infdis/jiz026 [doi]
AB  - Background: In July 2016, Sri Lanka replaced one intramuscular dose of
      inactivated poliovirus vaccine (IPV) with two doses of intradermal fractional IPV
      (fIPV) in its routine immunization schedule. We carried out a survey of
      seroprevalence of anti-polio antibodies in children who received two fIPV doses
      and compared it with those who received one full IPV dose. Methods: Children born
      between March and December 2016 were randomly selected from three Sri Lankan
      districts (Colombo, Badulla, Anuradhapura). Sera were collected and tested for
      presence of neutralizing antibodies to poliovirus types 1, 2, and 3. Results:
      Seroprevalence of anti-polio antibodies was 100% in all districts for poliovirus 
      type 1 (PV1) and PV3; it ranged between 90-93% for PV2 in children who received
      one full IPV dose and between 78-100% in those receiving two fIPV doses
      (p=0.217). Median reciprocal titers of anti-PV2 antibodies were similar in those 
      who received full IPV vs fIPV (1:64 vs 1:45 respectively; p=0.110).
      Interpretation: Our study demonstrated that Sri Lanka not only succeeded in
      maintaining very high primary immunization coverage but that it is feasible for a
      national immunization program to implement fIPV immunization and achieve high
      coverage with intradermal application. The seroprevalence of anti-PV2 antibodies 
      did not decrease after the introduction of fIPV.
FAU - Gamage, Deepa
AU  - Gamage D
AD  - Epidemiology Unit, Ministry of Health, Sri Lanka.
FAU - Mach, Ondrej
AU  - Mach O
AD  - Polio Eradication Department, World Health Organization, Geneva, Switzerland.
FAU - Ginige, Samitha
AU  - Ginige S
AD  - Epidemiology Unit, Ministry of Health, Sri Lanka.
FAU - Weldon, William C
AU  - Weldon WC
AD  - Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, 
      GA, USA.
FAU - Oberste, M Steven
AU  - Oberste MS
AD  - Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, 
      GA, USA.
FAU - Jeyaseelan, Visalakshi
AU  - Jeyaseelan V
AD  - Polio Eradication Department, World Health Organization, Geneva, Switzerland.
FAU - Sutter, Roland W
AU  - Sutter RW
AD  - Polio Eradication Department, World Health Organization, Geneva, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20190111
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
EDAT- 2019/01/17 06:00
MHDA- 2019/01/17 06:00
CRDT- 2019/01/17 06:00
PHST- 2018/12/18 00:00 [received]
PHST- 2019/01/17 06:00 [entrez]
PHST- 2019/01/17 06:00 [pubmed]
PHST- 2019/01/17 06:00 [medline]
AID - 5288498 [pii]
AID - 10.1093/infdis/jiz026 [doi]
PST - aheadofprint
SO  - J Infect Dis. 2019 Jan 11. pii: 5288498. doi: 10.1093/infdis/jiz026.