PMID- 30638762
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20190320
IS  - 1769-664X (Electronic)
IS  - 0929-693X (Linking)
VI  - 26
IP  - 2
DP  - 2019 Feb
TI  - Timeliness of routine immunization in non-preterm children less than 2 years old 
      using electronic data capture in an ambulatory setting in France in the context
      of vaccine hesitancy.
PG  - 56-64
LID - S0929-693X(18)30259-8 [pii]
LID - 10.1016/j.arcped.2018.11.011 [doi]
AB  - OBJECTIVES: The vaccine schedule was changed in 2013 in France, which resulted in
      fewer vaccinations. However, to maintain disease protection, both vaccine
      timeliness and high coverage should be respected. In the context of growing
      vaccine hesitancy, we aimed to describe compliance with the immunization program 
      according to the age recommended for each dose for non-preterm children less than
      2 years old. METHODS: Between May 2013 and April 2016, we used automated
      electronic data capture of electronic medical records for non-preterm children
      less than 2 years old. Children were followed up by 92 randomly selected
      pediatricians from the French ambulatory pediatricians group. Delayed
      immunization was defined as more than 15 days after the recommended age for the
      primary series of diphtheria-tetanus-pertussis-polio-Haemophilus influenzae
      b-hepatitis B (DTaP-IPV-Hib+/-HB) and 13-valent pneumococcal vaccine (PCV13), 2
      months for boosters, 1 month for measles-mumps-rubella (MMR)/meningococcal C
      conjugate (Men-C), and 6 months for the second dose of MMR. An association
      between delayed first dose and other doses delayed were described with odds
      ratios (ORs) and their 95% confidence intervals (CIs). RESULTS: Data for 22,097
      children in France with 124,702 vaccinations were analyzed: 21.8%, 20.4%, and
      30.7% of children had one or more delayed doses of DTaP-IPV-Hib+/-HB, PCV13, and 
      MMR vaccines, respectively. For 47.6% of children, the single-dose Men-C
      vaccination was delayed. A delayed first dose of DTaP-IPV-Hib+/-HB, PCV13, and
      MMR was associated with a delayed second dose of the same vaccine (OR 7.5 [95% CI
      6.6-8.6], 39.0 [34.1-44.8], and 23.5 [19.1-29.0], respectively) and with a third 
      dose of DTaP-IPV-Hib+/-HB and PCV13 (14.7 [13.3-17.7] and 3.7 [3.1-4.5]).
      CONCLUSION: This large study shows that the proportion of children with delayed
      vaccination in France was globally high and substantial for Men-C and the first
      MMR vaccination. Risk of a delayed second and third dose was increased with a
      delayed first dose, which may reflect vaccine hesitancy.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Rybak, A
AU  - Rybak A
AD  - Association francaise de pediatrie ambulatoire (AFPA), 78100
      Saint-Germain-en-Laye, France; Association Clinique et therapeutique infantile du
      Val-de-Marne (ACTIV), 94100 Saint-Maur-des-Fosses, France.
FAU - Vie le Sage, F
AU  - Vie le Sage F
AD  - Association francaise de pediatrie ambulatoire (AFPA), 78100
      Saint-Germain-en-Laye, France.
FAU - Bechet, S
AU  - Bechet S
AD  - Association Clinique et therapeutique infantile du Val-de-Marne (ACTIV), 94100
      Saint-Maur-des-Fosses, France.
FAU - Werner, A
AU  - Werner A
AD  - Association francaise de pediatrie ambulatoire (AFPA), 78100
      Saint-Germain-en-Laye, France.
FAU - Thiebault, G
AU  - Thiebault G
AD  - Association francaise de pediatrie ambulatoire (AFPA), 78100
      Saint-Germain-en-Laye, France.
FAU - Bakhache, P
AU  - Bakhache P
AD  - Association francaise de pediatrie ambulatoire (AFPA), 78100
      Saint-Germain-en-Laye, France.
FAU - Virey, B
AU  - Virey B
AD  - Association francaise de pediatrie ambulatoire (AFPA), 78100
      Saint-Germain-en-Laye, France.
FAU - Caulin, E
AU  - Caulin E
AD  - MSD Vaccins, 69007 Lyon, France.
FAU - Cohen, R
AU  - Cohen R
AD  - Association francaise de pediatrie ambulatoire (AFPA), 78100
      Saint-Germain-en-Laye, France; Association Clinique et therapeutique infantile du
      Val-de-Marne (ACTIV), 94100 Saint-Maur-des-Fosses, France; Service de
      neonatologie, unite Court Sejour, Petits Nourrissons, centre hospitalier
      Intercommunal de Creteil, 94010 Creteil France; Centre de recherche clinique,
      unite Petits Nourrissons, hopital Intercommunal de Creteil, 94010 Creteil,
      France; Universite Paris Est, IMRB-GRC GEMINI, 94010 Creteil, France.
FAU - Levy, C
AU  - Levy C
AD  - Association francaise de pediatrie ambulatoire (AFPA), 78100
      Saint-Germain-en-Laye, France; Association Clinique et therapeutique infantile du
      Val-de-Marne (ACTIV), 94100 Saint-Maur-des-Fosses, France; Service de
      neonatologie, unite Court Sejour, Petits Nourrissons, centre hospitalier
      Intercommunal de Creteil, 94010 Creteil France; Universite Paris Est, IMRB-GRC
      GEMINI, 94010 Creteil, France. Electronic address: corinne.levy@activ-france.fr.
LA  - eng
PT  - Journal Article
DEP - 20190110
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
SB  - IM
MH  - *Ambulatory Care
MH  - Child, Preschool
MH  - Data Collection/methods
MH  - Female
MH  - France
MH  - Humans
MH  - *Immunization Schedule
MH  - Infant
MH  - Male
MH  - *Patient Acceptance of Health Care
MH  - Time Factors
MH  - Vaccination Coverage/*statistics & numerical data
OTO - NOTNLM
OT  - Automatic data processing
OT  - Schedule
OT  - Vaccine
OT  - Vaccine delay
OT  - Vaccine hesitancy
EDAT- 2019/01/15 06:00
MHDA- 2019/03/21 06:00
CRDT- 2019/01/15 06:00
PHST- 2018/08/01 00:00 [received]
PHST- 2018/10/19 00:00 [revised]
PHST- 2018/11/17 00:00 [accepted]
PHST- 2019/01/15 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2019/01/15 06:00 [entrez]
AID - S0929-693X(18)30259-8 [pii]
AID - 10.1016/j.arcped.2018.11.011 [doi]
PST - ppublish
SO  - Arch Pediatr. 2019 Feb;26(2):56-64. doi: 10.1016/j.arcped.2018.11.011. Epub 2019 
      Jan 10.