PMID- 30626645
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20190723
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 116
IP  - 4
DP  - 2019 Jan 22
TI  - Multidrug-resistant plasmids repress chromosomally encoded T6SS to enable their
      dissemination.
PG  - 1378-1383
LID - 10.1073/pnas.1812557116 [doi]
AB  - Acinetobacter baumannii (Ab) is a nosocomial pathogen with one of the highest
      rates of multidrug resistance (MDR). This is partially due to transmissible
      plasmids. Many Ab strains harbor a constitutively active type VI secretion system
      (T6SS) that is employed to kill nonkin bacteria. T6SS and plasmid conjugation
      both involve cell-to-cell contact. Paradoxically, successful conjugation requires
      the survival of the recipient, which is the target of the T6SS. Thus, an active
      T6SS in either the donor or the recipient poses a challenge to plasmid
      conjugation. Here, we show that large conjugative MDR plasmids heavily rely on
      their distinctive ability to repress the T6SS of their hosts to enable their own 
      dissemination and the conjugation of other plasmids, contributing to the
      propagation of MDR among Acinetobacter isolates.
FAU - Di Venanzio, Gisela
AU  - Di Venanzio G
AD  - Department of Molecular Microbiology, Washington University School of Medicine in
      St. Louis, St. Louis, MO 63110.
FAU - Moon, Ki Hwan
AU  - Moon KH
AD  - Department of Molecular Microbiology, Washington University School of Medicine in
      St. Louis, St. Louis, MO 63110.
FAU - Weber, Brent S
AU  - Weber BS
AD  - Department of Molecular Microbiology, Washington University School of Medicine in
      St. Louis, St. Louis, MO 63110.
AD  - Department of Biological Sciences, University of Alberta, Edmonton, Alberta,
      Canada T6G2R3.
FAU - Lopez, Juvenal
AU  - Lopez J
AD  - Department of Molecular Microbiology, Washington University School of Medicine in
      St. Louis, St. Louis, MO 63110.
FAU - Ly, Pek Man
AU  - Ly PM
AD  - Department of Molecular Microbiology, Washington University School of Medicine in
      St. Louis, St. Louis, MO 63110.
FAU - Potter, Robert F
AU  - Potter RF
AD  - The Edison Family Center for Genome Sciences and System Biology, Washington
      University School of Medicine in St. Louis, St. Louis, MO 63108.
FAU - Dantas, Gautam
AU  - Dantas G
AD  - Department of Molecular Microbiology, Washington University School of Medicine in
      St. Louis, St. Louis, MO 63110.
AD  - The Edison Family Center for Genome Sciences and System Biology, Washington
      University School of Medicine in St. Louis, St. Louis, MO 63108.
AD  - Department of Pathology and Immunology, Washington University School of Medicine 
      in St. Louis, St. Louis, MO 63110.
AD  - Department of Biomedical Engineering, Washington University in St. Louis, St.
      Louis, MO 63130.
FAU - Feldman, Mario F
AU  - Feldman MF
AD  - Department of Molecular Microbiology, Washington University School of Medicine in
      St. Louis, St. Louis, MO 63110; mariofeldman@wustl.edu.
LA  - eng
GR  - R01 AI125363/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190109
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Bacterial Proteins)
RN  - 0 (Type VI Secretion Systems)
SB  - IM
MH  - Acinetobacter Infections/microbiology
MH  - Acinetobacter baumannii/*metabolism/*physiology
MH  - Bacterial Proteins/metabolism
MH  - Drug Resistance, Multiple, Bacterial/*physiology
MH  - Plasmids/metabolism
MH  - Type VI Secretion Systems/*physiology
PMC - PMC6347727
OTO - NOTNLM
OT  - *Acinetobacter
OT  - *MDR
OT  - *T6SS
OT  - *conjugation
OT  - *plasmids
COIS- The authors declare no conflict of interest.
EDAT- 2019/01/11 06:00
MHDA- 2019/03/26 06:00
CRDT- 2019/01/11 06:00
PHST- 2019/01/11 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2019/01/11 06:00 [entrez]
AID - 1812557116 [pii]
AID - 10.1073/pnas.1812557116 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1378-1383. doi:
      10.1073/pnas.1812557116. Epub 2019 Jan 9.