PMID- 30566443
OWN - NLM
STAT- MEDLINE
DCOM- 20190507
LR  - 20190507
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 12
DP  - 2018
TI  - Factors associated with self-reported falls, balance or walking difficulty in
      older survivors of breast, colorectal, lung, or prostate cancer: Results from
      Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey
      linkage.
PG  - e0208573
LID - 10.1371/journal.pone.0208573 [doi]
AB  - BACKGROUND: Cancer and its treatment affect body systems that are important in
      preventing falls and controlling balance/walking. This study examined factors
      associated with self-reported falls and balance/walking difficulty in the past 12
      months in older survivors of four major cancers. METHODS: This was a
      cross-sectional study analyzing population-based data from Surveillance,
      Epidemiology, and End Results-Medicare Health Outcomes Survey (SEER-MHOS). Data
      from cohorts 9 to 14 (January 2006 to December 2013) were extracted. Inclusion
      criteria were: age >/=65 years at cancer diagnosis, first MHOS completed during
      years 1-5 post-cancer diagnosis, first primary breast (n = 2725), colorectal (n =
      1646), lung (n = 752), and prostate (n = 4245) cancer, and availability of cancer
      staging information. Primary outcomes were self-reported falls and
      balance/walking difficulty in the past 12 months. Multivariable logistic
      regression was constructed for each cancer type to examine independent factors
      associated with falls and balance/walking difficulty. RESULTS: In all cancer
      types, advancing age at cancer diagnosis and dependence in activities of daily
      living were significant independent factors associated with increased odds of
      reporting falls and balance/walking difficulty in the past 12 months.
      Additionally, depression was independently associated with falls and sensory
      impairment in feet was independently linked to balance/walking difficulty in all 
      cancer types. Other independent factors of falls and balance/walking difficulty
      varied across cancer types. In breast cancer only, localized or regional cancer
      stage was significantly associated with increased odds of reporting falls and
      balance/walking difficulty, whereas treatment with radiation decreased the odds
      of falling. No association between falls and balance/walking difficulty with time
      since cancer diagnosis, cancer stage, or cancer treatment was found in
      colorectal, lung, and prostate cancer. CONCLUSION: There exists some
      heterogeneity in factors associated with self-reported falls and balance/walking 
      difficulty between different cancer types. Future research is necessary to
      ascertain factors predictive of falls and balance/walking difficulty in older
      cancer survivors, particularly factors related to cancer diagnosis and treatment.
FAU - Huang, Min H
AU  - Huang MH
AUID- ORCID: 0000-0003-1760-0072
AD  - Physical Therapy Department, College of Health Sciences, University of
      Michigan-Flint, Flint, MI, United States of America.
FAU - Blackwood, Jennifer
AU  - Blackwood J
AD  - Physical Therapy Department, College of Health Sciences, University of
      Michigan-Flint, Flint, MI, United States of America.
FAU - Godoshian, Monica
AU  - Godoshian M
AD  - Department of Physical Medicine and Rehabilitation, Michigan Medicine, University
      of Michigan, Ann Arbor, MI, United States of America.
FAU - Pfalzer, Lucinda
AU  - Pfalzer L
AD  - Physical Therapy Department, College of Health Sciences, University of
      Michigan-Flint, Flint, MI, United States of America.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181219
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Accidental Falls/*statistics & numerical data
MH  - Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/*pathology
MH  - Cancer Survivors
MH  - Colorectal Neoplasms/*pathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Lung Neoplasms/*pathology
MH  - Male
MH  - Medicare
MH  - *Postural Balance
MH  - Prostatic Neoplasms/*pathology
MH  - Self Report
MH  - Surveys and Questionnaires
MH  - United States
MH  - *Walking
PMC - PMC6300321
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/12/20 06:00
MHDA- 2019/05/08 06:00
CRDT- 2018/12/20 06:00
PHST- 2017/08/25 00:00 [received]
PHST- 2018/11/20 00:00 [accepted]
PHST- 2018/12/20 06:00 [entrez]
PHST- 2018/12/20 06:00 [pubmed]
PHST- 2019/05/08 06:00 [medline]
AID - 10.1371/journal.pone.0208573 [doi]
AID - PONE-D-17-31301 [pii]
PST - epublish
SO  - PLoS One. 2018 Dec 19;13(12):e0208573. doi: 10.1371/journal.pone.0208573.
      eCollection 2018.