PMID- 30555032
OWN - NLM
STAT- In-Data-Review
LR  - 20191120
IS  - 1552-5279 (Electronic)
IS  - 1552-5260 (Linking)
VI  - 15
IP  - 3
DP  - 2019 Mar
TI  - Subjective cognitive decline and rates of incident Alzheimer's disease and
      non-Alzheimer's disease dementia.
PG  - 465-476
LID - S1552-5260(18)33563-5 [pii]
LID - 10.1016/j.jalz.2018.10.003 [doi]
AB  - INTRODUCTION: In this multicenter study on subjective cognitive decline (SCD) in 
      community-based and memory clinic settings, we assessed the (1) incidence of
      Alzheimer's disease (AD) and non-AD dementia and (2) determinants of progression 
      to dementia. METHODS: Eleven cohorts provided 2978 participants with SCD and 1391
      controls. We estimated dementia incidence and identified risk factors using Cox
      proportional hazards models. RESULTS: In SCD, incidence of dementia was 17.7 (95%
      Poisson confidence interval 15.2-20.3)/1000 person-years (AD: 11.5 [9.6-13.7],
      non-AD: 6.1 [4.7-7.7]), compared with 14.2 (11.3-17.6) in controls (AD: 10.1
      [7.7-13.0], non-AD: 4.1 [2.6-6.0]). The risk of dementia was strongly increased
      in SCD in a memory clinic setting but less so in a community-based setting. In
      addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1-1.1]), lower 
      Mini-Mental State Examination (0.7 [0.66-0.8]), and apolipoprotein E epsilon4
      (1.8 [1.3-2.5]) increased the risk of dementia. DISCUSSION: SCD can precede both 
      AD and non-AD dementia. Despite their younger age, individuals with SCD in a
      memory clinic setting have a higher risk of dementia than those in
      community-based cohorts.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Slot, Rosalinde E R
AU  - Slot RER
AD  - Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience,
      Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
FAU - Sikkes, Sietske A M
AU  - Sikkes SAM
AD  - Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience,
      Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands;
      Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam,
      Amsterdam UMC, Amsterdam, the Netherlands.
FAU - Berkhof, Johannes
AU  - Berkhof J
AD  - Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam,
      Amsterdam UMC, Amsterdam, the Netherlands.
FAU - Brodaty, Henry
AU  - Brodaty H
AD  - Center for Healthy Brain Ageing and Dementia Centre for Research Collaboration,
      University of New South Wales, Sydney, Australia.
FAU - Buckley, Rachel
AU  - Buckley R
AD  - University of Melbourne, Melbourne, Australia; The Florey Institutes of
      Neurosciences and Mental Health, Melbourne, Australia; Harvard Medical School,
      Massachusetts General Hospital, Boston, MA, USA.
FAU - Cavedo, Enrica
AU  - Cavedo E
AD  - AXA Research Fund & Sorbonne University Chair, Paris, France; Sorbonne
      University, GRC n degrees 21, Alzheimer Precision Medicine (APM), AP-HP,
      Pitie-Salpetriere Hospital, Paris, France; Brain & Spine Institute (ICM), INSERM 
      U 1127, CNRS UMR 7225, Paris, France; Institute of Memory and Alzheimer's Disease
      (IM2A), Department of Neurology, Pitie-Salpetriere Hospital, AP-HP, Paris,
      France.
FAU - Dardiotis, Efthimios
AU  - Dardiotis E
AD  - Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa,
      Greece.
FAU - Guillo-Benarous, Francoise
AU  - Guillo-Benarous F
AD  - New York University Alzheimer's Disease Center, NYU Langone Medical Center, New
      York, NY, USA.
FAU - Hampel, Harald
AU  - Hampel H
AD  - AXA Research Fund & Sorbonne University Chair, Paris, France; Sorbonne
      University, GRC n degrees 21, Alzheimer Precision Medicine (APM), AP-HP,
      Pitie-Salpetriere Hospital, Paris, France; Brain & Spine Institute (ICM), INSERM 
      U 1127, CNRS UMR 7225, Paris, France; Institute of Memory and Alzheimer's Disease
      (IM2A), Department of Neurology, Pitie-Salpetriere Hospital, AP-HP, Paris,
      France.
FAU - Kochan, Nicole A
AU  - Kochan NA
AD  - Center for Healthy Brain Ageing and Dementia Centre for Research Collaboration,
      University of New South Wales, Sydney, Australia; Neuropsychiatric Institute,
      Prince of Wales Hospital, Randwick, Australia.
FAU - Lista, Simone
AU  - Lista S
AD  - AXA Research Fund & Sorbonne University Chair, Paris, France; Sorbonne
      University, GRC n degrees 21, Alzheimer Precision Medicine (APM), AP-HP,
      Pitie-Salpetriere Hospital, Paris, France; Brain & Spine Institute (ICM), INSERM 
      U 1127, CNRS UMR 7225, Paris, France; Institute of Memory and Alzheimer's Disease
      (IM2A), Department of Neurology, Pitie-Salpetriere Hospital, AP-HP, Paris,
      France.
FAU - Luck, Tobias
AU  - Luck T
AD  - Institute of Social Medicine, Occupational Health and Public Health (ISAP),
      Faculty of Medicine, University of Leipzig, Leipzig, Germany; Social Psychiatry, 
      Department of Economic and Social Sciences, University of Applied Sciences
      Nordhausen, Nordhausen, Germany.
FAU - Maruff, Paul
AU  - Maruff P
AD  - The Florey Institutes of Neurosciences and Mental Health, Melbourne, Australia;
      Cogstate Ltd., Melbourne, Australia.
FAU - Molinuevo, Jose Luis
AU  - Molinuevo JL
AD  - Neurology Department, Hospital Clinic i Universitari-IDIBAPS and BarcelonaBeta
      Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
FAU - Kornhuber, Johannes
AU  - Kornhuber J
AD  - Friedrich Alexander University Erlangen-Nurnberg, Erlangen, Germany.
FAU - Reisberg, Barry
AU  - Reisberg B
AD  - New York University Alzheimer's Disease Center, NYU Langone Medical Center, New
      York, NY, USA.
FAU - Riedel-Heller, Steffi G
AU  - Riedel-Heller SG
AD  - Institute of Social Medicine, Occupational Health and Public Health (ISAP),
      Faculty of Medicine, University of Leipzig, Leipzig, Germany.
FAU - Risacher, Shannon L
AU  - Risacher SL
AD  - Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana
      University School of Medicine Indianapolis, IN, USA; Indiana Alzheimer Disease
      Center, Indiana University School of Medicine Indianapolis, IN, USA.
FAU - Roehr, Susanne
AU  - Roehr S
AD  - Institute of Social Medicine, Occupational Health and Public Health (ISAP),
      Faculty of Medicine, University of Leipzig, Leipzig, Germany; LIFE - Leipzig
      Research Center for Civilization Diseases, University of Leipzig, Leipzig,
      Germany.
FAU - Sachdev, Perminder S
AU  - Sachdev PS
AD  - Center for Healthy Brain Ageing and Dementia Centre for Research Collaboration,
      University of New South Wales, Sydney, Australia; Neuropsychiatric Institute,
      Prince of Wales Hospital, Randwick, Australia.
FAU - Scarmeas, Nikolaos
AU  - Scarmeas N
AD  - National and Kapodistrian University of Athens, Athens, Greece; Department of
      Neurology, Columbia University Medical Center, New York, NY, USA.
FAU - Scheltens, Philip
AU  - Scheltens P
AD  - Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience,
      Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
FAU - Shulman, Melanie B
AU  - Shulman MB
AD  - New York University Alzheimer's Disease Center, NYU Langone Medical Center, New
      York, NY, USA.
FAU - Saykin, Andrew J
AU  - Saykin AJ
AD  - Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana
      University School of Medicine Indianapolis, IN, USA; Indiana Alzheimer Disease
      Center, Indiana University School of Medicine Indianapolis, IN, USA.
FAU - Verfaillie, Sander C J
AU  - Verfaillie SCJ
AD  - Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience,
      Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
FAU - Visser, Pieter Jelle
AU  - Visser PJ
AD  - Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience,
      Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands;
      Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg,
      Maastricht University, Maastricht, the Netherlands.
FAU - Vos, Stephanie J B
AU  - Vos SJB
AD  - Department of Psychiatry and Neuropsychology, Alzheimer Center Limburg,
      Maastricht University, Maastricht, the Netherlands.
FAU - Wagner, Michael
AU  - Wagner M
AD  - DZNE, German Center for Neurodegenerative Diseases, Germany; Department of
      Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
FAU - Wolfsgruber, Steffen
AU  - Wolfsgruber S
AD  - DZNE, German Center for Neurodegenerative Diseases, Germany; Department of
      Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
FAU - Jessen, Frank
AU  - Jessen F
AD  - DZNE, German Center for Neurodegenerative Diseases, Germany; Psychiatry
      Department, University of Cologne, Cologne, Germany.
CN  - Alzheimer's Disease Neuroimaging Initiative
CN  - DESCRIPA working group
CN  - INSIGHT-preAD study group
CN  - SCD-I working group
FAU - van der Flier, Wiesje M
AU  - van der Flier WM
AD  - Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience,
      Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands;
      Department of Epidemiology and Biostatistics, Vrije Universiteit Amsterdam,
      Amsterdam UMC, Amsterdam, the Netherlands. Electronic address:
      wm.vdflier@vumc.nl.
LA  - eng
GR  - R01 AG019771/AG/NIA NIH HHS/United States
GR  - P30 AG010133/AG/NIA NIH HHS/United States
GR  - U01 AG024904/AG/NIA NIH HHS/United States
GR  - P30 AG008051/AG/NIA NIH HHS/United States
GR  - R01 AG003051/AG/NIA NIH HHS/United States
GR  - K01 AG049050/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20181213
PL  - United States
TA  - Alzheimers Dement
JT  - Alzheimer's & dementia : the journal of the Alzheimer's Association
JID - 101231978
SB  - IM
PMC - PMC6465066
MID - NIHMS1021068
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Dementia Lewy bodies
OT  - Dementia incidence
OT  - Frontotemporal dementia
OT  - Preclinical Alzheimer's disease
OT  - Subjective cognitive decline
OT  - Vascular dementia
IR  - Boada M
FIR - Boada, Merce
IR  - de Deyn PP
FIR - de Deyn, Peter Paul
IR  - Jones R
FIR - Jones, Roy
IR  - Frisoni G
FIR - Frisoni, Giovanni
IR  - Spiru L
FIR - Spiru, Luiza
IR  - Nobili F
FIR - Nobili, Flavio
IR  - Freund-Levi Y
FIR - Freund-Levi, Yvonne
IR  - Soininen H
FIR - Soininen, Hilkka
IR  - Verhey F
FIR - Verhey, Frans
IR  - Wallin AK
FIR - Wallin, Asa K
IR  - Touchon J
FIR - Touchon, Jacques
IR  - Rikkert MO
FIR - Rikkert, Marcel Olde
IR  - Rigaud AS
FIR - Rigaud, Anne-Sophie
IR  - Bullock R
FIR - Bullock, Roger
IR  - Tsolaki M
FIR - Tsolaki, Magda
IR  - Vellas B
FIR - Vellas, Bruno
IR  - Wilcock G
FIR - Wilcock, Gordon
IR  - Hampel H
FIR - Hampel, Harald
IR  - Froelich L
FIR - Froelich, Lutz
IR  - Bakardjian H
FIR - Bakardjian, Hovagim
IR  - Benali H
FIR - Benali, Habib
IR  - Bertin H
FIR - Bertin, Hugo
IR  - Bonheur J
FIR - Bonheur, Joel
IR  - Boukadida L
FIR - Boukadida, Laurie
IR  - Boukerrou N
FIR - Boukerrou, Nadia
IR  - Cavedo E
FIR - Cavedo, Enrica
IR  - Chiesa P
FIR - Chiesa, Patrizia
IR  - Colliot O
FIR - Colliot, Olivier
IR  - Dubois B
FIR - Dubois, Bruno
IR  - Dubois M
FIR - Dubois, Marion
IR  - Epelbaum S
FIR - Epelbaum, Stephane
IR  - Gagliardi G
FIR - Gagliardi, Geoffroy
IR  - Genthon R
FIR - Genthon, Remy
IR  - Habert MO
FIR - Habert, Marie-Odile
IR  - Hampel H
FIR - Hampel, Harald
IR  - Houot M
FIR - Houot, Marion
IR  - Kas A
FIR - Kas, Aurelie
IR  - Lamari F
FIR - Lamari, Foudil
IR  - Levy M
FIR - Levy, Marcel
IR  - Lista S
FIR - Lista, Simone
IR  - Metzinger C
FIR - Metzinger, Christiane
IR  - Mochel F
FIR - Mochel, Fanny
IR  - Nyasse F
FIR - Nyasse, Francis
IR  - Poisson C
FIR - Poisson, Catherine
IR  - Potier MC
FIR - Potier, Marie-Claude
IR  - Revillon M
FIR - Revillon, Marie
IR  - Santos A
FIR - Santos, Antonio
IR  - Andrade KS
FIR - Andrade, Katia Santos
IR  - Sole M
FIR - Sole, Marine
IR  - Surtee M
FIR - Surtee, Mohmed
IR  - Thiebaud de Schotten M
FIR - Thiebaud de Schotten, Michel
IR  - Vergallo A
FIR - Vergallo, Andrea
IR  - Younsi N
FIR - Younsi, Nadjia
EDAT- 2018/12/18 06:00
MHDA- 2018/12/18 06:00
CRDT- 2018/12/18 06:00
PHST- 2018/01/04 00:00 [received]
PHST- 2018/09/03 00:00 [revised]
PHST- 2018/10/03 00:00 [accepted]
PHST- 2018/12/18 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2018/12/18 06:00 [entrez]
AID - S1552-5260(18)33563-5 [pii]
AID - 10.1016/j.jalz.2018.10.003 [doi]
PST - ppublish
SO  - Alzheimers Dement. 2019 Mar;15(3):465-476. doi: 10.1016/j.jalz.2018.10.003. Epub 
      2018 Dec 13.