PMID- 30507580
OWN - NLM
STAT- In-Data-Review
LR  - 20181219
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 66
IP  - 4
DP  - 2018
TI  - Spatial Navigation in the Elderly with Alzheimer's Disease: A Cross-Sectional
      Study.
PG  - 1683-1694
LID - 10.3233/JAD-180819 [doi]
AB  - BACKGROUND: Spatial navigation is a fundamental cognitive ability that allows an 
      individual to maintain independence by facilitating the safe movement from one
      place to another. It emerges as one of the first deficits in patients with
      Alzheimer's disease (AD). OBJECTIVE: To compare spatial navigation performance in
      the healthy elderly and AD patients through use of the Floor Maze Test (FMT)- an 
      easy-to-apply two-dimensional (2D) maze- and determine which cognitive and
      functional capacities were associated with performance in this task. METHODS: The
      FMT was administered to 24 AD patients and 36 healthy controls. Spatial
      navigation was evaluated through the FMT. Functional capacity was evaluated
      through the Senior Fitness Test battery of tests. Cognitive functions were
      evaluated through the Mini-Mental State Examination (MMSE), verbal fluency, digit
      span test, and the Rey Auditory Verbal Learning Test (RAVLT). RESULTS: The group 
      with AD was significantly slower and presented more errors at all stages of the
      FMT. Planning Time (PT) performance was associated with cardiorespiratory
      resistance (Step test) and delayed memory according to the RAVLT (R2 = 0.395, p <
      0.001). Performance in the Immediate Maze Time (IMT) and Delayed Maze Time (DMT) 
      was associated with global cognitive status (MMSE) (R2 = 0.509) and delayed
      memory (R2 = 0.540). CONCLUSION: Patients with AD present significant spatial
      navigation deficits. Their performance on the FMT is influenced by
      cardiorespiratory capacity, memory, and global cognitive function. As exercise
      helps to improve executive function and functional capacity, future intervention 
      studies should be carried out to analyze the possible effects of physical
      exercise on spatial navigation.
FAU - Zanco, Marcos
AU  - Zanco M
AD  - Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 
      Brazil.
FAU - Placido, Jessica
AU  - Placido J
AD  - Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 
      Brazil.
FAU - Marinho, Valeska
AU  - Marinho V
AD  - Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 
      Brazil.
FAU - Ferreira, Jose Vinicius
AU  - Ferreira JV
AD  - Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 
      Brazil.
FAU - de Oliveira, Felipe
AU  - de Oliveira F
AD  - Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 
      Brazil.
FAU - Monteiro-Junior, Renato
AU  - Monteiro-Junior R
AD  - Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 
      Brazil.
AD  - Universidade Estadual de Montes Claros, Minas Gerais, Brazil.
FAU - Barca, Maria
AU  - Barca M
AD  - Norwegian Advisory Unit for Ageing and Health, Vestfold Hospital Trust, T-nsberg,
      Norway.
AD  - Department of Geriatric Medicine, Oslo University Hospital, Ulleval, Oslo,
      Norway.
FAU - Engedal, Knut
AU  - Engedal K
AD  - Norwegian Advisory Unit for Ageing and Health, Vestfold Hospital Trust, T-nsberg,
      Norway.
AD  - Department of Geriatric Medicine, Oslo University Hospital, Ulleval, Oslo,
      Norway.
FAU - Laks, Jerson
AU  - Laks J
AD  - Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 
      Brazil.
FAU - Deslandes, Andrea
AU  - Deslandes A
AD  - Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 
      Brazil.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - executive function
OT  - functional capacity
OT  - spatial navigation
EDAT- 2018/12/07 06:00
MHDA- 2018/12/07 06:00
CRDT- 2018/12/04 06:00
PHST- 2018/12/07 06:00 [pubmed]
PHST- 2018/12/07 06:00 [medline]
PHST- 2018/12/04 06:00 [entrez]
AID - JAD180819 [pii]
AID - 10.3233/JAD-180819 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2018;66(4):1683-1694. doi: 10.3233/JAD-180819.