PMID- 30478162
OWN - NLM
STAT- In-Data-Review
LR  - 20190203
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 63
IP  - 2
DP  - 2019 Feb
TI  - Comparative Genomics of Serial Candida glabrata Isolates and the Rapid
      Acquisition of Echinocandin Resistance during Therapy.
LID - e01628-18 [pii]
LID - 10.1128/AAC.01628-18 [doi]
AB  - The opportunistic pathogen Candida glabrata shows a concerning increase in drug
      resistance. Here, we present the analysis of two serial bloodstream isolates,
      obtained 12 days apart. Both isolates show pan-azole resistance and echinocandin 
      resistance was acquired during the sampling interval. Genome sequencing
      identified nine nonsynonymous SNVs between the strains, including a S663P
      substitution in FKS2 and previously undescribed SNVs in MDE1 and FPR1, offering
      insight into how C. glabrata acquires drug resistance and adapts to a human host.
CI  - Copyright (c) 2019 American Society for Microbiology.
FAU - Barber, Amelia E
AU  - Barber AE
AD  - National Reference Center for Invasive Mycoses, Leibniz Institute for Natural
      Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
FAU - Weber, Michael
AU  - Weber M
AD  - National Reference Center for Invasive Mycoses, Leibniz Institute for Natural
      Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
AD  - Systems Biology and Bioinformatics, Leibniz Institute for Natural Product
      Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
AD  - Research Group PiDOMICs, Leibniz Institute for Natural Product Research and
      Infection Biology-Hans Knoell Institute, Jena, Germany.
FAU - Kaerger, Kerstin
AU  - Kaerger K
AD  - National Reference Center for Invasive Mycoses, Leibniz Institute for Natural
      Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
FAU - Linde, Jorg
AU  - Linde J
AD  - Systems Biology and Bioinformatics, Leibniz Institute for Natural Product
      Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
AD  - Research Group PiDOMICs, Leibniz Institute for Natural Product Research and
      Infection Biology-Hans Knoell Institute, Jena, Germany.
FAU - Golz, Hanna
AU  - Golz H
AD  - Institute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical
      Center-University of Freiburg, Freiburg, Germany.
FAU - Duerschmied, Daniel
AU  - Duerschmied D
AD  - Department of Cardiology and Angiology I, Heart Center, University of Freiburg,
      Freiburg, Germany.
AD  - Department of Medicine III: Medical Intensive Care, Medical Center, Faculty of
      Medicine, University of Freiburg, Freiburg, Germany.
FAU - Markert, Antonie
AU  - Markert A
AD  - Department of Medicine III: Medical Intensive Care, Medical Center, Faculty of
      Medicine, University of Freiburg, Freiburg, Germany.
FAU - Guthke, Reinhard
AU  - Guthke R
AD  - Systems Biology and Bioinformatics, Leibniz Institute for Natural Product
      Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
FAU - Walther, Grit
AU  - Walther G
AD  - National Reference Center for Invasive Mycoses, Leibniz Institute for Natural
      Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany.
FAU - Kurzai, Oliver
AU  - Kurzai O
AUID- ORCID: https://orcid.org/0000-0002-7277-2646
AD  - National Reference Center for Invasive Mycoses, Leibniz Institute for Natural
      Product Research and Infection Biology-Hans Knoell Institute, Jena, Germany
      okurzai@hygiene.uni-wuerzburg.de.
AD  - Institute for Hygiene and Microbiology, Julius Maximilian University of
      Wuerzburg, Wuerzburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20190129
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
PMC - PMC6355595
OTO - NOTNLM
OT  - Candida
OT  - Candida glabrata
OT  - candidiasis
OT  - comparative genomics
OT  - fungus
OT  - resistance
EDAT- 2018/11/28 06:00
MHDA- 2018/11/28 06:00
CRDT- 2018/11/28 06:00
PMCR- 2019/07/29 00:00
PHST- 2018/08/10 00:00 [received]
PHST- 2018/11/18 00:00 [accepted]
PHST- 2019/07/29 00:00 [pmc-release]
PHST- 2018/11/28 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2018/11/28 06:00 [entrez]
AID - AAC.01628-18 [pii]
AID - 10.1128/AAC.01628-18 [doi]
PST - epublish
SO  - Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: AAC.01628-18. doi:
      10.1128/AAC.01628-18. Print 2019 Feb.