PMID- 30465928
OWN - NLM
STAT- MEDLINE
DCOM- 20190401
LR  - 20190401
IS  - 1872-7654 (Electronic)
IS  - 0301-2115 (Linking)
VI  - 232
DP  - 2019 Jan
TI  - Pregestational diabetes and fetal heart rate in the first trimester of pregnancy.
PG  - 30-32
LID - S0301-2115(18)31077-7 [pii]
LID - 10.1016/j.ejogrb.2018.11.003 [doi]
AB  - OBJECTIVE: The aim of our study is to evaluate if pregestational diabetes affects
      fetal heart rate (FHR) readings at 11-14 weeks of pregnancy. STUDY DESIGN: For
      each patient, we recorded age, body mass index (BMI), presence of pregestational 
      diabetes, nuchal translucency (NT), FHR, crown-rump length (CRL), biparietal
      diameter (BPD) and gestational age. Pregnancies were grouped according to the
      presence or absence of pregestational diabetes and maternal and fetal variables
      were compared. Ordinal regression analysis was performed to assess the influence 
      of maternal and fetal variables on the FHR. RESULTS: We included 994 pregnancies 
      from 2009 to 2016. Kruskal-Wallis test showed that median FHR was higher in women
      with pregestational diabetes than in controls (161; IQR 11 vs. 158; IQR 10, chi2 
      = 5.13, p = 0.02). Ordinal regression analysis showed that differences in FHR
      were significantly correlated with the presence of pregestational diabetes (p =
      0.007) and the CRL (p = 0.042) but not with the maternal BMI, maternal age,
      gestational age, BPD and NT. CONCLUSIONS: First trimester FHR is higher in
      diabetic pregnancies than in non-diabetic pregnancies. Therefore, further
      research is needed to assess whether these pregnancies may benefit from a
      correction of FHR for a better estimation of the chromosomal abnormalities risk.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Sirico, Angelo
AU  - Sirico A
AD  - Department of Neurosciences, Reproductive and Dentistry Sciences, University
      Federico II, Naples, Italy.
FAU - Sarno, Laura
AU  - Sarno L
AD  - Department of Neurosciences, Reproductive and Dentistry Sciences, University
      Federico II, Naples, Italy.
FAU - Zullo, Fulvio
AU  - Zullo F
AD  - Department of Neurosciences, Reproductive and Dentistry Sciences, University
      Federico II, Naples, Italy.
FAU - Martinelli, Pasquale
AU  - Martinelli P
AD  - Department of Neurosciences, Reproductive and Dentistry Sciences, University
      Federico II, Naples, Italy.
FAU - Maruotti, Giuseppe M
AU  - Maruotti GM
AD  - Department of Neurosciences, Reproductive and Dentistry Sciences, University
      Federico II, Naples, Italy. Electronic address: gm.mar@tiscali.it.
LA  - eng
PT  - Journal Article
DEP - 20181105
PL  - Ireland
TA  - Eur J Obstet Gynecol Reprod Biol
JT  - European journal of obstetrics, gynecology, and reproductive biology
JID - 0375672
SB  - IM
MH  - Adult
MH  - Crown-Rump Length
MH  - Diabetes Mellitus/*physiopathology
MH  - Echocardiography
MH  - Female
MH  - Heart Rate, Fetal/*physiology
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Trimester, First/*physiology
MH  - Pregnancy in Diabetics/*physiopathology
MH  - Ultrasonography, Prenatal
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Fetal echocardiography
OT  - First trimester pregnancy
OT  - Screening
OT  - Ultrasound
EDAT- 2018/11/23 06:00
MHDA- 2019/04/02 06:00
CRDT- 2018/11/23 06:00
PHST- 2018/06/14 00:00 [received]
PHST- 2018/10/15 00:00 [revised]
PHST- 2018/11/04 00:00 [accepted]
PHST- 2018/11/23 06:00 [pubmed]
PHST- 2019/04/02 06:00 [medline]
PHST- 2018/11/23 06:00 [entrez]
AID - S0301-2115(18)31077-7 [pii]
AID - 10.1016/j.ejogrb.2018.11.003 [doi]
PST - ppublish
SO  - Eur J Obstet Gynecol Reprod Biol. 2019 Jan;232:30-32. doi:
      10.1016/j.ejogrb.2018.11.003. Epub 2018 Nov 5.