PMID- 30411701
STAT- Publisher
LR  - 20181109
IS  - 1018-9068 (Print)
IS  - 1018-9068 (Linking)
DP  - 2018 Nov 9
TI  - Re-evolution of asthma management: dilemmas and new paradigms.
PG  - 0
LID - 10.18176/jiaci.0345 [doi]
AB  - Asthma is one of the most common inflammatory diseases in the world, and the main
      treatment goal is to achieve the best level of control for each patient. Although
      every patient is different, there are several clinical practice guidelines that
      can help physicians to manage this respiratory condition. However, the
      recommendations made by the different guidelines are not always identical, and
      new data on different management strategies are being continuously released,
      which can mislead both patients and physicians. Our aim with this article is to
      summarize the main controversies in terms of management and treatment
      recommendations in asthma guidelines, revise the most recent scientific evidence 
      published so far and pinpoint some possible solution to these dilemmas. This
      review, however, does not aim to issue new recommendations or to challenge
      evidence-based guidelines. As a conclusion of this article, the authors
      considered that more tools are necessary to reach and measure optimal asthma
      control, to better assess the impact of asthma in patients' lives. In addition,
      it would be of utmost importance to appraise more accurately the short-term and
      long-term effectiveness and safety of asthma therapies, and the possibilities of 
      successful immunomodulation.
FAU - Valero, A
AU  - Valero A
AD  - Seccion de Alergologia. Servicio de Neumologia y Alergia. Hospital Clinic de
      Barcelona. Universitat de Barcelona, IDIBAPS, CIBER de Enfermedades Respiratorias
      (CIBERES), Espana.
FAU - Olaguibel, J
AU  - Olaguibel J
AD  - Unidad de Asma Grave. Servicio de Alergologia. Complejo Hospitalario de Navarra. 
      Pamplona and CIBER de Enfermedades Respiratorias (CIBERES).
FAU - Delgado, J
AU  - Delgado J
AD  - Unidad de Gestion Clinica de Alergologia. Hospital Virgen Macarena. Sevilla.
FAU - Plaza, V
AU  - Plaza V
AD  - Servei de Pneumologia i Al.lergia. Hospital de la Santa Creu i Sant Pau. Institut
      d'Investigacio Biomedica Sant Pau (IIB Sant Pau). Universitat Autonoma de
      Barcelona. Barcelona, Spain.
FAU - Alvarez, F
AU  - Alvarez F
AD  - Unidad de Asma. Unidad Medico-Quirurgica de Enfermedades Respiratorias (UMQER).
      Hospital Universitario "Virgen del Rocio". Sevilla.
FAU - Molina, J
AU  - Molina J
AD  - CS Francia. Direccion Asistencial Oeste. Fuenlabrada. Madrid.
FAU - Mascaros, E
AU  - Mascaros E
AD  - Centro de Salud Fuente de San Luis. Departamento Hospital Dr Peset, Valencia,
FAU - Quirce, S
AU  - Quirce S
AD  - Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ) and
      CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20181109
PL  - Spain
TA  - J Investig Allergol Clin Immunol
JT  - Journal of investigational allergology & clinical immunology
JID - 9107858
OT  - Asthma control
OT  - Asthma management
OT  - Dilemma
OT  - Guidelines
OT  - Immunotherapy
OT  - Inhaled corticosteroids
OT  - Paradoxes
OT  - Treatment
EDAT- 2018/11/10 06:00
MHDA- 2018/11/10 06:00
CRDT- 2018/11/10 06:00
PHST- 2018/11/10 06:00 [entrez]
PHST- 2018/11/10 06:00 [pubmed]
PHST- 2018/11/10 06:00 [medline]
AID - 10.18176/jiaci.0345 [doi]
PST - aheadofprint
SO  - J Investig Allergol Clin Immunol. 2018 Nov 9:0. doi: 10.18176/jiaci.0345.