PMID- 30409781
OWN - NLM
STAT- MEDLINE
DCOM- 20190805
LR  - 20190805
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Linking)
VI  - 68
IP  - 2
DP  - 2019 Feb
TI  - Risk Factor Modeling for Cardiovascular Disease in Type 1 Diabetes in the
      Pittsburgh Epidemiology of Diabetes Complications (EDC) Study: A Comparison With 
      the Diabetes Control and Complications Trial/Epidemiology of Diabetes
      Interventions and Complications Study (DCCT/EDIC).
PG  - 409-419
LID - 10.2337/db18-0515 [doi]
AB  - In a recent Diabetes Control and Complications Trial (DCCT)/Epidemiology of
      Diabetes Interventions and Complications (EDIC) study report, mean HbA1c was the 
      strongest predictor of cardiovascular disease (CVD) after age. In DCCT/EDIC, mean
      diabetes duration was 6 years (median 4) at baseline and those with high blood
      pressure or cholesterol were excluded. We now replicate these analyses in the
      Pittsburgh Epidemiology of Diabetes Complications (EDC) prospective cohort study 
      of childhood-onset (at <17 years of age) type 1 diabetes, with similar age (mean 
      27 years in both studies) but longer diabetes duration (mean 19 years and median 
      18 years) and no CVD risk factor exclusion at baseline. CVD incidence (CVD death,
      myocardial infarction (MI), stroke, revascularization, angina, or ischemic
      electrocardiogram) was associated with diabetes duration, most recent albumin
      excretion rate (AER), updated mean triglycerides, baseline hypertension, baseline
      LDL cholesterol, and most recent HbA1c Major atherosclerotic cardiovascular
      events (CVD death, MI, or stroke) were associated with diabetes duration, most
      recent AER, baseline systolic blood pressure, baseline smoking, and updated mean 
      HbA1c Compared with findings in DCCT/EDIC, traditional risk factors similarly
      predicted CVD; however AER predominates in EDC and HbA1c in DCCT/EDIC. Thus, the 
      relative impact of HbA1c and kidney disease in type 1 diabetes varies according
      to diabetes duration.
CI  - (c) 2018 by the American Diabetes Association.
FAU - Miller, Rachel G
AU  - Miller RG
AUID- ORCID: 0000-0003-1845-8477
AD  - Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
      millerr@edc.pitt.edu.
FAU - Costacou, Tina
AU  - Costacou T
AUID- ORCID: 0000-0001-9303-3810
AD  - Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
FAU - Orchard, Trevor J
AU  - Orchard TJ
AD  - Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
LA  - eng
GR  - R01 DK034818/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20181108
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
MH  - Adolescent
MH  - Blood Glucose/metabolism
MH  - Blood Pressure/physiology
MH  - Cardiovascular Diseases/*epidemiology/*etiology/metabolism
MH  - Child
MH  - Diabetes Complications/epidemiology/metabolism
MH  - Diabetes Mellitus, Type 1/*epidemiology/*etiology/metabolism
MH  - Female
MH  - Glycated Hemoglobin A/metabolism
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC6341302
EDAT- 2018/11/10 06:00
MHDA- 2019/08/06 06:00
CRDT- 2018/11/10 06:00
PMCR- 2020/02/01 00:00
PHST- 2018/05/08 00:00 [received]
PHST- 2018/11/03 00:00 [accepted]
PHST- 2020/02/01 00:00 [pmc-release]
PHST- 2018/11/10 06:00 [pubmed]
PHST- 2019/08/06 06:00 [medline]
PHST- 2018/11/10 06:00 [entrez]
AID - db18-0515 [pii]
AID - 10.2337/db18-0515 [doi]
PST - ppublish
SO  - Diabetes. 2019 Feb;68(2):409-419. doi: 10.2337/db18-0515. Epub 2018 Nov 8.