PMID- 30381388
OWN - NLM
STAT- Publisher
LR  - 20181101
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
DP  - 2018 Oct 31
TI  - Conjunctival myxoid stromal tumour: a distinctive clinicopathological and
      immunohistochemical study.
LID - bjophthalmol-2018-312747 [pii]
LID - 10.1136/bjophthalmol-2018-312747 [doi]
AB  - BACKGROUND/AIMS: To describe the clinicopathological and immunohistochemical
      characteristics of 10 patients representing a new entity of benign conjunctival
      myxoid stromal tumours. METHODS: Retrospective review of clinical findings,
      histopathological and immunohistochemical studies identified 10 cases of
      low-grade conjunctival myxoid stromal tumours. Specimens were routinely processed
      and stained with H&E. Immunohistochemical stains for CD34, CD68, vimentin, S100, 
      smooth muscle actin (SMA), myosin, desmin, actin, Bcl-2 and Ki-67 were performed.
      Specific stains for Alcian-blue periodic acid-Schiff (AB-PAS) and aldehyde
      fuchsin stains were also performed. RESULTS: Ten patients with an average age of 
      45.6+/-11.1 years had a tender white or faint yellow to red mass on the bulbar
      conjunctiva. All the lesions were completely removed, and none of the patients
      relapsed. Histologically, all neoplasms consisted of spindle-shaped cells that
      showed signs of pseudonuclear inclusions, multinuclear cells and had no atypia.
      The stroma consisted of a large amount of mucus and was infiltrated with delicate
      to ropey collagens, a few mast cells and new vessels. Immunohistochemical stains 
      were positive for CD34, vimentin and Bcl-2; partial positive for CD68; very low
      for Ki-67; and negative for S100, SMA, myosin, desmin and actin. AB-PAS suggested
      that the stroma was mucinous. CONCLUSIONS: These rare benign mesenchymal
      conjunctival tumours are mostly unilateral and occur in the bulbar conjunctiva.
      Complete resection is the radical treatment. These lesions are characterised by
      multiple spindle cells, a large amount of mucus, and sharing similar basic
      histopathological features with conjunctival myxoma and conjunctival stromal
      tumour. We suggest naming these lesions 'conjunctival myxoid stromal tumours'.
CI  - (c) Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and
      permissions. Published by BMJ.
FAU - Qin, Xiao-Yi
AU  - Qin XY
AD  - Eye Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Jin, Zhe-Hao
AU  - Jin ZH
AD  - Eye Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Wang, You-Pei
AU  - Wang YP
FAU - Zhang, Zong-Duan
AU  - Zhang ZD
AUID- ORCID: http://orcid.org/0000-0002-9509-231X
AD  - Eye Hospital of Wenzhou Medical University, Wenzhou, China zzduan@yeah.net.
LA  - eng
PT  - Journal Article
DEP - 20181031
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
OTO - NOTNLM
OT  - clinicopathological features
OT  - conjunctiva
OT  - myxoid stromal tumor
COIS- Competing interests: None declared.
EDAT- 2018/11/02 06:00
MHDA- 2018/11/02 06:00
CRDT- 2018/11/02 06:00
PHST- 2018/06/19 00:00 [received]
PHST- 2018/09/25 00:00 [revised]
PHST- 2018/10/11 00:00 [accepted]
PHST- 2018/11/02 06:00 [entrez]
PHST- 2018/11/02 06:00 [pubmed]
PHST- 2018/11/02 06:00 [medline]
AID - bjophthalmol-2018-312747 [pii]
AID - 10.1136/bjophthalmol-2018-312747 [doi]
PST - aheadofprint
SO  - Br J Ophthalmol. 2018 Oct 31. pii: bjophthalmol-2018-312747. doi:
      10.1136/bjophthalmol-2018-312747.