PMID- 30362112
OWN - NLM
STAT- MEDLINE
DCOM- 20190129
LR  - 20190129
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 144
IP  - 1
DP  - 2019 Jan
TI  - Neutrophil-to-lymphocyte ratio and platelet indices in pre-eclampsia.
PG  - 16-20
LID - 10.1002/ijgo.12701 [doi]
AB  - OBJECTIVE: To compare the neutrophil-to-lymphocyte ratio (NLR),
      platelet-to-lymphocyte ratio (PLR), and platelet indices between women with
      pre-eclampsia and normotensive pregnant women. METHODS: A cross-sectional study
      conducted from January to July 2017 at a tertiary care hospital in Delhi, India. 
      The study compared pregnant women aged 18-40 years with pre-eclampsia diagnosed
      at term with healthy pregnant women matched for gestational age. Venous blood
      samples were drawn and complete blood count was analyzed. The parameters recorded
      were hemoglobin, red cell distribution width (RDW), platelet count, mean platelet
      volume (MPV), plateletcrit, and platelet distribution width. RESULTS: There were 
      67 women included in each group. NLR was higher in women with pre-eclampsia
      compared with the control group (6.8 +/- 7.6 vs 3.0 +/- 0.98; P=0.001). Both PLR 
      (14.18 +/- 14.4 vs 9.54 +/- 3.6; P=0.012) and MPV (9.45 +/- 1.19 vs 9.02 +/- 1.1;
      P=0.029) were higher in the study group compared with the control group. Platelet
      count was lower in pre-eclamptic women compared with the control group (188 +/-
      89.7 vs 200.1 +/- 62.36; P=0.014). RDW was also higher in the study group
      (P=0.025). CONCLUSIONS: The present study found that the inflammatory markers
      NLR, PLR, RDW, and MPV were higher in women with pre-eclampsia. Measuring NLR and
      PLR may be useful in predicting pre-eclampsia among women at high risk during
      prenatal follow-up.
CI  - (c) 2018 International Federation of Gynecology and Obstetrics.
FAU - Gogoi, Priyanka
AU  - Gogoi P
AD  - Department of Pathology, University College of Medical Sciences and Guru Teg
      Bahadur Hospital, Delhi, India.
FAU - Sinha, Pallavi
AU  - Sinha P
AD  - Department of Pathology, University College of Medical Sciences and Guru Teg
      Bahadur Hospital, Delhi, India.
FAU - Gupta, Bindiya
AU  - Gupta B
AD  - Department of Obstetrics and Gynecology, University College of Medical Sciences
      and Guru Teg Bahadur Hospital, Delhi, India.
FAU - Firmal, Priyanka
AU  - Firmal P
AD  - Department of Obstetrics and Gynecology, University College of Medical Sciences
      and Guru Teg Bahadur Hospital, Delhi, India.
FAU - Rajaram, Shalini
AU  - Rajaram S
AD  - Department of Obstetrics and Gynecology, University College of Medical Sciences
      and Guru Teg Bahadur Hospital, Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20181111
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Erythrocyte Indices
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - India
MH  - Leukocyte Count
MH  - Lymphocyte Count
MH  - *Lymphocytes
MH  - *Neutrophils
MH  - Pre-Eclampsia/*blood/diagnosis
MH  - Pregnancy
MH  - Young Adult
OTO - NOTNLM
OT  - High-risk pregnancy
OT  - Hypertension
OT  - Mean platelet volume
OT  - Neutrophil-to-lymphocyte ratio
OT  - Platelet-to-lymphocyte ratio
OT  - Pre-eclampsia
EDAT- 2018/10/27 06:00
MHDA- 2019/01/30 06:00
CRDT- 2018/10/27 06:00
PHST- 2018/03/27 00:00 [received]
PHST- 2018/08/08 00:00 [revised]
PHST- 2018/10/24 00:00 [accepted]
PHST- 2018/10/27 06:00 [pubmed]
PHST- 2019/01/30 06:00 [medline]
PHST- 2018/10/27 06:00 [entrez]
AID - 10.1002/ijgo.12701 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2019 Jan;144(1):16-20. doi: 10.1002/ijgo.12701. Epub 2018 
      Nov 11.