PMID- 30359431
OWN - NLM
STAT- MEDLINE
DCOM- 20190410
LR  - 20190410
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 10
DP  - 2018
TI  - Detrimental association between betel nut chewing and colorectal polyps in adult 
      populations.
PG  - e0206383
LID - 10.1371/journal.pone.0206383 [doi]
AB  - Adverse systemic effect caused by betel nut had been reported for decades. Our
      aim was to determine whether betel nut had detrimental impact on the development 
      of colorectal polyps in general population. Participants who attended health
      examinations at the Tri-Service General Hospital (TSGH) from 2010 to 2016 were
      included in the study. The habit of betel nut chewing was obtained from a
      self-reported questionnaire. Colorectal polyps were diagnosed by colonoscopies
      operated by experienced physicians. A logistic regression model was used for the 
      association between betel nut chewing with the presence of colorectal polyps.
      After adjustment for pertinent information such as age, gender, biochemistry data
      and personal history, the odd ratios (ORs) of colorectal polyps among betel nut
      chewers was 1.49 (95%CI: 1.14-1.94). Besides, betel nut chewers in the higher
      percentage body fat (PBF) group had higher risk for developing colorectal polyps 
      with ORs of 2.07 (95%CI:1.23-3.47). Subjects with habit of betel nut chewing were
      associated with an increased risk of colorectal polyps in Taiwanese general
      population. Screening for betel nut chewing history and encouraging cessation
      might offer improved quality of life. A further research for this association was
      warranted.
FAU - Chen, Yuan-Yuei
AU  - Chen YY
AD  - Department of Internal Medicine, Tri-Service General Hospital Songshan Branch and
      School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of 
      China.
AD  - Division of Family Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
FAU - Fang, Wen-Hui
AU  - Fang WH
AD  - Division of Family Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Health Management Center, Department of Family and Community Medicine,
      Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan,
      Republic of China.
FAU - Wang, Chung-Ching
AU  - Wang CC
AD  - Division of Family Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Health Management Center, Department of Family and Community Medicine,
      Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan,
      Republic of China.
FAU - Kao, Tung-Wei
AU  - Kao TW
AD  - Division of Family Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Health Management Center, Department of Family and Community Medicine,
      Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan,
      Republic of China.
AD  - Division of Geriatric Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Graduate Institute of Clinical Medical, College of Medicine, National Taiwan
      University, Taipei, Taiwan, Republic of China.
FAU - Chang, Yaw-Wen
AU  - Chang YW
AD  - Division of Family Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Health Management Center, Department of Family and Community Medicine,
      Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan,
      Republic of China.
AD  - Division of Geriatric Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
FAU - Yang, Hui-Fang
AU  - Yang HF
AD  - Division of Family Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Health Management Center, Department of Family and Community Medicine,
      Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan,
      Republic of China.
AD  - Division of Geriatric Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
FAU - Wu, Chen-Jung
AU  - Wu CJ
AD  - Division of Family Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Division of Geriatric Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Division of Family Medicine, Department of Community Medicine, Taoyuan Armed
      Forces General Hospital, Taoyuan, Taiwan, Republic of China.
FAU - Sun, Yu-Shan
AU  - Sun YS
AD  - Division of Family Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Health Management Center, Department of Family and Community Medicine,
      Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan,
      Republic of China.
AD  - Division of Geriatric Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
FAU - Chen, Wei-Liang
AU  - Chen WL
AUID- ORCID: 0000-0003-0784-230X
AD  - Division of Family Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
AD  - Health Management Center, Department of Family and Community Medicine,
      Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan,
      Republic of China.
AD  - Division of Geriatric Medicine, Department of Family and Community Medicine,
      Tri-Service General Hospital and School of Medicine, National Defense Medical
      Center, Taipei, Taiwan, Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20181025
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adipose Tissue
MH  - Adult
MH  - Areca/*adverse effects
MH  - Colonic Polyps/diagnostic imaging/*epidemiology
MH  - Colorectal Neoplasms/diagnostic imaging/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Mastication
MH  - Middle Aged
MH  - Odds Ratio
MH  - Quality of Life
MH  - Risk Factors
MH  - Taiwan/epidemiology
PMC - PMC6201956
COIS- The authors have declared that no competing interests exist.
EDAT- 2018/10/26 06:00
MHDA- 2019/04/11 06:00
CRDT- 2018/10/26 06:00
PHST- 2018/05/21 00:00 [received]
PHST- 2018/10/11 00:00 [accepted]
PHST- 2018/10/26 06:00 [entrez]
PHST- 2018/10/26 06:00 [pubmed]
PHST- 2019/04/11 06:00 [medline]
AID - 10.1371/journal.pone.0206383 [doi]
AID - PONE-D-18-15248 [pii]
PST - epublish
SO  - PLoS One. 2018 Oct 25;13(10):e0206383. doi: 10.1371/journal.pone.0206383.
      eCollection 2018.