PMID- 30279113
OWN - NLM
STAT- MEDLINE
DCOM- 20190403
LR  - 20190403
IS  - 1437-7780 (Electronic)
IS  - 1341-321X (Linking)
VI  - 25
IP  - 3
DP  - 2019 Mar
TI  - Comparative analysis of methicillin-resistant Staphylococcus aureus isolated from
      outpatients of dermatology unit in hospitals and clinics.
PG  - 233-237
LID - S1341-321X(18)30288-5 [pii]
LID - 10.1016/j.jiac.2018.09.002 [doi]
AB  - Community-onset methicillin-resistant Staphylococcus aureus (CO-MRSA) is a
      causative agent of intractable skin infections. In general, clinical symptoms of 
      hospital outpatients with skin infections are severer than those of clinic
      patients. Hence, molecular epidemiological features of the CO-MRSA strains from
      hospital outpatients are predicted to be different from those of clinic patients.
      Here, we conducted a comparative analysis for CO-MRSA isolates from outpatients
      with impetigo in hospitals and clinics located in the same district of Tokyo,
      Japan. Incidence of MRSA infection was higher in hospital outpatients (21.5%,
      20/93 isolates) than in clinic patients (14.5%, 121/845 isolates). The resistance
      rate to clindamycin, which is a common topical antimicrobial agent in
      dermatology, in the isolates from hospital outpatients (60.0%) was higher than
      those from clinic patients (31.4%). Proportion of the staphylococcal cassette
      chromosome (SCC) mec type II, which is a representative type of hospital-acquired
      MRSA in Japan, in the isolates from hospital outpatients (65.0%) was
      significantly higher than those from clinic patients (30.6%) (P < 0.01).
      Multilocus sequence typing showed that the clonal complex 89-SCCmec type II
      (CC89-II) clone, which exhibits clindamycin resistance, was the most predominant 
      (55.0%) in the isolates from hospital outpatients. On the other hand, all CC8-IV,
      CC121-V, and CC89-V clones accounted for 60% in clinic patients were susceptible 
      to clindamycin. Our findings suggested that the clindamycin-resistant CC89-II
      CO-MRSA clone might be more related to skin infections in hospital outpatients
      than clinic patients.
CI  - Copyright (c) 2018 Japanese Society of Chemotherapy and The Japanese Association 
      for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
FAU - Nakaminami, Hidemasa
AU  - Nakaminami H
AD  - Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and 
      Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. Electronic
      address: nakami@toyaku.ac.jp.
FAU - Sugiyama, Taku
AU  - Sugiyama T
AD  - Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and 
      Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
FAU - Okamura, Yuu
AU  - Okamura Y
AD  - Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and 
      Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
FAU - Hanawa, Mamiko
AU  - Hanawa M
AD  - Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and 
      Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
FAU - Abou, Masaki
AU  - Abou M
AD  - Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and 
      Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
FAU - Sawada, Kaori
AU  - Sawada K
AD  - Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and 
      Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
FAU - Chiba, Yoshiyuki
AU  - Chiba Y
AD  - Department of Dermatology, National Hospital Organisation Disaster Medical
      Center, 3256 Midori, Tachikawa, Tokyo 190-0014, Japan.
FAU - Kobayashi, Yoko
AU  - Kobayashi Y
AD  - Kobayashi Dermatology Clinic, 1-20-6 Shinmachi, Hino, Tokyo 191-0002, Japan.
FAU - Kawasaki, Satoru
AU  - Kawasaki S
AD  - Kawasaki Dermatology Clinic, 1-53-1 Suwa, Tama, Tokyo 206-0024, Japan.
FAU - Ueki, Toru
AU  - Ueki T
AD  - Ueki Dermatology Plastic Surgery, 3-6-24 Sandamachi, Hachioji, Tokyo 193-0832,
      Japan.
FAU - Funatsu, Sakae
AU  - Funatsu S
AD  - Kawano Dermatology Clinic, 1009-4 Takahata, Hino, Tokyo 191-0031, Japan.
FAU - Nagatani, Tetsuo
AU  - Nagatani T
AD  - Department of Dermatology, Tokyo Medical University Hachioji Medical Center, 1163
      Tatemachi, Hachioji, Tokyo 193-0998, Japan.
FAU - Noguchi, Norihisa
AU  - Noguchi N
AD  - Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and 
      Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180929
PL  - Netherlands
TA  - J Infect Chemother
JT  - Journal of infection and chemotherapy : official journal of the Japan Society of 
      Chemotherapy
JID - 9608375
RN  - 0 (Anti-Bacterial Agents)
RN  - 3U02EL437C (Clindamycin)
SB  - IM
MH  - Ambulatory Care Facilities
MH  - Anti-Bacterial Agents/pharmacology
MH  - Clindamycin/pharmacology
MH  - Cohort Studies
MH  - *Community-Acquired Infections/epidemiology/microbiology
MH  - Drug Resistance, Bacterial
MH  - Female
MH  - Hospitals
MH  - Humans
MH  - *Impetigo/epidemiology/microbiology
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - *Methicillin-Resistant Staphylococcus aureus/drug effects/isolation &
      purification
MH  - Microbial Sensitivity Tests
OTO - NOTNLM
OT  - CC89-II
OT  - Clindamycin resistance
OT  - Community-acquired methicillin-resistant Staphylococcus aureus
OT  - Skin infection
EDAT- 2018/10/04 06:00
MHDA- 2019/04/04 06:00
CRDT- 2018/10/04 06:00
PHST- 2018/06/27 00:00 [received]
PHST- 2018/08/29 00:00 [revised]
PHST- 2018/09/03 00:00 [accepted]
PHST- 2018/10/04 06:00 [pubmed]
PHST- 2019/04/04 06:00 [medline]
PHST- 2018/10/04 06:00 [entrez]
AID - S1341-321X(18)30288-5 [pii]
AID - 10.1016/j.jiac.2018.09.002 [doi]
PST - ppublish
SO  - J Infect Chemother. 2019 Mar;25(3):233-237. doi: 10.1016/j.jiac.2018.09.002. Epub
      2018 Sep 29.