PMID- 30259516
OWN - NLM
STAT- MEDLINE
DCOM- 20181011
LR  - 20181011
IS  - 1096-9098 (Electronic)
IS  - 0022-4790 (Linking)
VI  - 118
IP  - 3
DP  - 2018 Sep
TI  - A negative-doughnut distal resection margin less than 5 mm does not affect
      prognosis in rectal cancer.
PG  - 536-543
LID - 10.1002/jso.25161 [doi]
AB  - AIM: Many issues relating to the distal margin of anterior resection of the
      rectum still exist. We aimed to investigate whether negative distal resection
      margin (DRM) and positive DRM in the main specimen with negative doughnut has
      equivalent prognosis in patients with rectal cancer. METHODS: We included 287
      patients with rectal cancer, including 69 cases with positive margins and 218
      cases with negative margins, all of whom underwent regular follow-up. Survival
      rate was calculated using Kaplan-Meier survival analysis, while the log-rank test
      was used to determine statistical difference. Prognostic factors were found using
      the Cox regression model. RESULTS: There was no significant difference in
      clinicopathological features between the two groups with the exception of tumor
      location. Positive findings in the DRM with negative findings in the doughnut
      resection do not affect the overall survival, local recurrence, or distant
      metastasis. Factors relating to resection margin, such as the length of
      resection, negative, or positive findings, were not found to be prognostic.
      CONCLUSION: Given postoperative pathology results with positive DRM but negative 
      findings in the doughnut resection, a second surgery was not necessary. Instead, 
      adjuvant radiochemotherapy and close follow-up will suffice.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Keranmu, Adili
AU  - Keranmu A
AUID- ORCID: http://orcid.org/0000-0002-5697-7211
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center,
      Shanghai, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai,
      China.
FAU - Liu, Hai-Ning
AU  - Liu HN
AD  - Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai,
      China.
FAU - Wu, Yu-Chen
AU  - Wu YC
AUID- ORCID: http://orcid.org/0000-0003-3781-7690
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center,
      Shanghai, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai,
      China.
FAU - Liu, Tao-Tao
AU  - Liu TT
AD  - Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai,
      China.
FAU - Li, Cong
AU  - Li C
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center,
      Shanghai, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai,
      China.
FAU - Guo, Tian-An
AU  - Guo TA
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center,
      Shanghai, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai,
      China.
FAU - Liu, Fang-Qi
AU  - Liu FQ
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center,
      Shanghai, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai,
      China.
FAU - Zheng, Hong-Tu
AU  - Zheng HT
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center,
      Shanghai, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai,
      China.
FAU - Xu, Ye
AU  - Xu Y
AD  - Department of Colorectal Surgery, Fudan University Shanghai Cancer Center,
      Shanghai, China.
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai,
      China.
LA  - eng
GR  - 13140902100/Shanghai Science and Technology Planning Fund
GR  - 2014ZYJB0101/Shanghai combination study project for major diseases
GR  - No. 81472620/The National Natural Science Foundation of China
PT  - Journal Article
PL  - United States
TA  - J Surg Oncol
JT  - Journal of surgical oncology
JID - 0222643
SB  - IM
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - *Margins of Excision
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Recurrence, Local/pathology/*surgery
MH  - Prognosis
MH  - Rectal Neoplasms/pathology/*surgery
MH  - Survival Rate
OTO - NOTNLM
OT  - anterior resection
OT  - distal resection margin
OT  - overall survival
OT  - rectal neoplasms
EDAT- 2018/09/28 06:00
MHDA- 2018/10/12 06:00
CRDT- 2018/09/28 06:00
PHST- 2018/03/14 00:00 [received]
PHST- 2018/06/15 00:00 [accepted]
PHST- 2018/09/28 06:00 [entrez]
PHST- 2018/09/28 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
AID - 10.1002/jso.25161 [doi]
PST - ppublish
SO  - J Surg Oncol. 2018 Sep;118(3):536-543. doi: 10.1002/jso.25161.