PMID- 30243064
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Linking)
VI  - 103
DP  - 2018 Nov
TI  - The value of tumour debulking for patients with extensive multi-organ metastatic 
      colorectal cancer.
PG  - 160-164
LID - S0959-8049(18)30981-X [pii]
LID - 10.1016/j.ejca.2018.07.012 [doi]
AB  - Local treatment of metastases by surgical resection or other ablative therapies
      is technically feasible in an increasing number of patients with multi-organ
      metastatic cancer. This results in a growing debate on whether patients with
      extensive disease, that is traditionally deemed unresectable, may benefit from
      local treatment of metastases when added to standard palliative systemic therapy.
      For selected patients with oligometastatic colorectal cancer, local treatment of 
      metastases has become the standard of care based on retrospective reports showing
      long-term survival rates. In addition to systemic therapy, preliminary evidence
      suggests that patients with extensive metastatic colorectal cancer may also
      benefit from local treatment. Here, we present the future perspectives based on
      the available literature on local treatment approaches in colorectal cancer.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Gootjes, Elske C
AU  - Gootjes EC
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology,
      Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
FAU - Bakkerus, Lotte
AU  - Bakkerus L
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology,
      Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
FAU - Ten Tije, Albert J
AU  - Ten Tije AJ
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology,
      Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands;
      Department of Medical Oncology, Amphia Hospital, Breda, The Netherlands.
FAU - Witteveen, Petronella O
AU  - Witteveen PO
AD  - Department of Medical Oncology, UMC Utrecht Cancer Center, The Netherlands.
FAU - Buffart, Tineke E
AU  - Buffart TE
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology,
      Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
FAU - Bridgewater, John A
AU  - Bridgewater JA
AD  - University College London Cancer Institute, London, UK.
FAU - Primrose, John N
AU  - Primrose JN
AD  - University Surgery and Cancer Sciences Division, University of Southampton,
      Southampton General Hospital, Southampton UK.
FAU - Verhoef, Cornelis
AU  - Verhoef C
AD  - Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, The
      Netherlands.
FAU - Verheul, Henk M W
AU  - Verheul HMW
AD  - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology,
      Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
      Electronic address: h.verheul@vumc.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180919
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
SB  - IM
MH  - Colorectal Neoplasms/pathology/*surgery
MH  - Cytoreduction Surgical Procedures/*methods
MH  - Humans
MH  - Neoplasm Metastasis
OTO - NOTNLM
OT  - *Colorectal carcinoma
OT  - *Extrahepatic disease
OT  - *Tumour debulking
EDAT- 2018/09/23 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/09/23 06:00
PHST- 2018/06/23 00:00 [received]
PHST- 2018/07/08 00:00 [accepted]
PHST- 2018/09/23 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/09/23 06:00 [entrez]
AID - S0959-8049(18)30981-X [pii]
AID - 10.1016/j.ejca.2018.07.012 [doi]
PST - ppublish
SO  - Eur J Cancer. 2018 Nov;103:160-164. doi: 10.1016/j.ejca.2018.07.012. Epub 2018
      Sep 19.