PMID- 30191566
OWN - NLM
STAT- In-Process
LR  - 20190130
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 41
IP  - 11
DP  - 2018 Nov
TI  - The effect of statins on the recurrence rate of atrial fibrillation after
      catheter ablation: A meta-analysis.
PG  - 1420-1427
LID - 10.1111/pace.13485 [doi]
AB  - BACKGROUND: To more precisely evaluate the effect of statins on patients with
      atrial fibrillation (AF) after catheter ablation, we performed a meta-analysis of
      published studies. METHODS: We searched PubMed, EMBASE, and Cochrane Library for 
      all relevant published articles from the date of inception to April 2017. Odds
      ratios (OR) and 95% confidence intervals (CIs) were then calculated and pooled
      using a random-effects model. Statistical heterogeneity was evaluated using the
      I(2) statistic. RESULTS: Nine studies with a total of 1,607 patients were
      included in the analysis. Overall, statins did not reduce the recurrence rate of 
      AF after catheter ablation (OR 0.81, 95% CI 0.59-1.10, P = 0.18). However, in the
      subgroup analysis, the randomized control trial (RCT) group significantly reduced
      the recurrence of AF (OR 0.47, 95% CI 0.30-0.75, P = 0.001). Conversely, the
      retrospective cohort study subgroup also had a negative result (OR 1.03, 95% CI
      0.78-1.36, P = 0.82). CONCLUSIONS: Statin use was associated with a significantly
      lower AF recurrence rate in RCTs but not in the whole analysis and the
      observational studies.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Peng, Hong
AU  - Peng H
AD  - Department of Cardiology, the First Affiliated Hospital of Chongqing Medical
      University, Chongqing, China.
FAU - Yang, Yuan
AU  - Yang Y
AD  - Department of Cardiology, the First Affiliated Hospital of Chongqing Medical
      University, Chongqing, China.
FAU - Zhao, Yue
AU  - Zhao Y
AD  - Department of Cardiology, the First Affiliated Hospital of Chongqing Medical
      University, Chongqing, China.
FAU - Xiao, Hua
AU  - Xiao H
AUID- ORCID: 0000-0002-6116-627X
AD  - Department of Cardiology, the First Affiliated Hospital of Chongqing Medical
      University, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20181004
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
OTO - NOTNLM
OT  - *atrial fibrillation
OT  - *catheter ablation
OT  - *statins
EDAT- 2018/09/08 06:00
MHDA- 2018/09/08 06:00
CRDT- 2018/09/08 06:00
PHST- 2018/03/26 00:00 [received]
PHST- 2018/07/23 00:00 [revised]
PHST- 2018/08/13 00:00 [accepted]
PHST- 2018/09/08 06:00 [pubmed]
PHST- 2018/09/08 06:00 [medline]
PHST- 2018/09/08 06:00 [entrez]
AID - 10.1111/pace.13485 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2018 Nov;41(11):1420-1427. doi: 10.1111/pace.13485.
      Epub 2018 Oct 4.